Search Results - "Lin King, John V."
-
1
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
Published in Nature (London) (03-09-2020)“…The transient receptor potential ion channel TRPA1 is expressed by primary afferent nerve fibres, in which it functions as a low-threshold sensor for…”
Get full text
Journal Article -
2
Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition
Published in Nature communications (05-04-2022)“…Presequence protease (PreP), a 117 kDa mitochondrial M16C metalloprotease vital for mitochondrial proteostasis, degrades presequence peptides cleaved off from…”
Get full text
Journal Article -
3
Sensory TRP Channels in Three Dimensions
Published in Annual review of biochemistry (21-06-2022)“…Transient receptor potential (TRP) ion channels are sophisticated signaling machines that detect a wide variety of environmental and physiological signals…”
Get full text
Journal Article -
4
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
Published in Cell (05-09-2019)“…TRPA1 is a chemosensory ion channel that functions as a sentinel for structurally diverse electrophilic irritants. Channel activation occurs through an unusual…”
Get full text
Journal Article -
5
Kv1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis
Published in Proceedings of the National Academy of Sciences - PNAS (31-05-2022)“…Adult hippocampal neurogenesis is critical for learning and memory, and aberrant adult neurogenesis has been implicated in cognitive decline associated with…”
Get full text
Journal Article -
6
K v 1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis
Published in Proceedings of the National Academy of Sciences - PNAS (31-05-2022)“…SignificanceDespite decades of research on adult neurogenesis, little is known about the role of bioelectric signaling in this process. In this study, we…”
Get full text
Journal Article