Search Results - "Lin, Zuoxian"

Ameliorating Effect of Umbilical Cord Mesenchymal Stem Cells in a Human Induced Pluripotent Stem Cell Model of Dravet Syndrome by Zhao, Huifang, Li, Shuai, He, Lang, Tang, Feng, Han, Xiaobo, Deng, Weiyue, Lin, Zuoxian, Huang, Rongqi, Li, Zhiyuan

“…Dravet syndrome (DS) is a form of severe childhood-onset refractory epilepsy typically caused by a heterozygous loss-of-function mutation. DS patient-derived…”
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Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage by Tian, Chao, Han, Xiaobo, He, Lang, Tang, Feng, Huang, Rongqi, Lin, Zuoxian, Li, Shuai, Deng, Sihao, Xu, Junjie, Huang, Hualin, Zhao, Huifang, Li, Zhiyuan

“…P2X7 receptor (P2X7R) is an ATP-gated non-selective cation channel which mediates ATP-induced inflammation in macrophages. Transient receptor potential (TRP)…”
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Transient Receptor Potential Ankyrin 1 Contributes to Lysophosphatidylcholine-Induced Intracellular Calcium Regulation and THP-1-Derived Macrophage Activation by Tian, Chao, Huang, Rongqi, Tang, Feng, Lin, Zuoxian, Cheng, Na, Han, Xiaobo, Li, Shuai, Zhou, Peng, Deng, Sihao, Huang, Hualin, Zhao, Huifang, Xu, Junjie, Li, Zhiyuan

“…Lysophosphatidylcholine (LPC) is a major atherogenic lipid that stimulates an increase in mitochondrial reactive oxygen species (mtROS) and the release of…”
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Direct Conversion of Human Urine Cells to Neurons by Small Molecules by Xu, Guosheng, Wu, Feima, Gu, Xiaotong, Zhang, Jiaye, You, Kai, Chen, Yan, Getachew, Anteneh, Zhuang, Yuanqi, Zhong, Xiaofen, Lin, Zuoxian, Guo, Dongsheng, Yang, Fan, Pan, Tingcai, Wei, Hongcheng, Li, Yin-xiong

“…Transdifferentiation of other cell type into human neuronal cells (hNCs) provides a platform for neural disease modeling, drug screening and potential…”
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Transient receptor potential ankyrin 1 contributes to the lysophosphatidylcholine-induced oxidative stress and cytotoxicity in OLN-93 oligodendrocyte by Tian, Chao, Li, Shuai, He, Lang, Han, Xiaobo, Tang, Feng, Huang, Rongqi, Lin, Zuoxian, Deng, Sihao, Xu, Junjie, Huang, Hualin, Zhao, Huifang, Li, Zhiyuan

“…Transient receptor potential ankyrin 1 (TRPA1), the non-selective cation channel, was found that can mediate the generation of multiple sclerosis, while the…”
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Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle by Deng, Weiyue, Zhang, Yuying, Wang, Wei, Song, Aishi, Mukama, Omar, Huang, Jiarong, Han, Xiaobo, Deng, Sihao, Lin, Zuoxian, Habimana, Jean du Dieu, Huang, Rongqi, Peng, Kexin, Ni, Bing, Zhang, Shusheng, Yan, Xiaoxin, Li, Ji, Wu, Lin-Ping, Li, Zhiyuan

“…Abstract Background Alopecia areata (AA) is a common autoimmune hair loss disease with increasing incidence. Corticosteroids are the most widely used for hair…”
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Novel role of TRPV2 in promoting the cytotoxicity of H2O2-mediated oxidative stress in Human hepatoma cells by Ma, Wenbo, Li, Caiyue, Yin, Shikui, Liu, Jingxin, Gao, Chao, Lin, Zuoxian, Huang, Rongqi, Huang, Jufang, Li, Zhiyuan

“…Oxidative stress is important for the initiation and progression of cancers, which confers the cells with a survival advantage by inducing oxidative adaption…”
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Rational Programming of Cas12a for Early-Stage Detection of COVID-19 by Lateral Flow Assay and Portable Real-Time Fluorescence Readout Facilities by Yi, Zhijian, de Dieu Habimana, Jean, Mukama, Omar, Li, Zhiyuan, Odiwuor, Nelson, Jing, Hanzhi, Nie, Chengrong, Hu, Mei, Lin, Zuoxian, Wei, Hongping, Zeng, Lingwen

“…Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus has led to a global pandemic with a high spread rate and pathogenicity. Thus, with limited…”
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Generation of corrected-hiPSC (USTCi001-A-1) from epilepsy patient iPSCs using TALEN-mediated editing of the SCN1A gene by Zhao, Huifang, He, Lang, Li, Shuai, Huang, Hualin, Tang, Feng, Han, Xiaobo, Lin, Zuoxian, Tian, Chao, Huang, Rongqi, Zhou, Peng, Huang, Jufang, Deng, Sihao, Li, Zhiyuan

“…Dravet syndrome is a neurological disorder characterized by treatment-resistant polymorphic seizures, primarily caused by loss-of-function in the SCN1A gene…”
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Mechanism of HERG potassium channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride by Long, Yan, Lin, Zuoxian, Xia, Menghang, Zheng, Wei, Li, Zhiyuan

“…Tetra-n-octylammonium bromide and benzethonium chloride are synthetic quaternary ammonium salts that are widely used in hospitals and industries for the…”
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Generation of iPSC line (USTCi001-A) from human skin fibroblasts of a patient with epilepsy by Zhao, Huifang, Li, Shuai, He, Lang, Han, Xiaobo, Huang, Hualin, Tang, Feng, Lin, Zuoxian, Deng, Sihao, Tian, Chao, Huang, Rongqi, Li, Zhiyuan

“…Epilepsy is a neurological disorder, characterized by recurrent (two or more) epileptic seizures resulting from excessive and abnormal cortical neural…”
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Generation of induced pluripotent stem cell line (CSUXHi002-A) from a patient with spinocerebellar ataxia type 1 by He, Lang, Zhao, Huifang, Li, Shuai, Han, Xiaobo, Chen, Zhao, Wang, Chunrong, Tian, Chao, Tang, Feng, Huang, Rongqi, Lin, Zuoxian, Li, Zhiyuan, Tang, Beisha, Jiang, Hong

“…Spinocerebellar ataxia type 1 (SCA1) is a hereditary neurodegenerative disease caused by CAG repeated expansion in ATXN1 gene. We generated induced pluripotent…”
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Generation of UCiPSC-derived neurospheres for cell therapy and its application by Li, Shuai, Zhao, Huifang, Han, Xiaobo, Ni, Bin, He, Lang, Mukama, Omar, de Dieu Habimana, Jean, Lin, Zuoxian, Huang, Rongqi, Huang, Hualin, Tian, Chao, Tang, Feng, Li, Zhiyuan

“…Neural stem cell (NSC) therapy remains one of the most potential approaches for the treatment of neurological disorders. The discovery of human induced…”
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A heterozygous SCN1A (c.A5768G/+) mutant human induced pluripotent stem cell line (USTCi002-A) generated using TALEN-mediated precise gene editing by Zhao, Huifang, Li, Shuai, Lin, Zuoxian, He, Lang, Deng, Weiyue, Han, Xiaobo, Tang, Feng, Cheng, Na, Zhou, Peng, Huang, Rongqi, Deng, Sihao, Huang, Jufang, Li, Zhiyuan

“…Severe mycological epilepsy of infancy is a catastrophic disease with preferential dysfunction of interneurons, frequentepisoderate, cognitive and sudden…”
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Generation of a tdTomato-GAD67 reporter human epilepsia mutation induced pluripotent stem cell line, USTCi001-A-2, using CRISPR/Cas9 editing by Zhao, Huifang, He, Lang, Huang, Hualin, Li, Shuai, Cheng, Na, Tang, Feng, Han, Xiaobo, Lin, Zuoxian, Huang, Rongqi, Zhou, Peng, Deng, Sihao, Huang, Jufang, Li, Zhiyuan

“…Dravet syndrome is an epileptic encephalopathy largely due to haploinsufficiency of the voltage-gated sodium channel Nav1.1 that is expressed primarily in…”
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Generation of iPSC line (GIBHi001-A) from a patient with autism spectrum disorder by Li, Shuai, Zhao, Huifang, Huang, Rongqi, He, Lang, Tian, Chao, Huang, Hualin, Han, Xiaobo, Tang, Feng, Lin, Zuoxian, Deng, Sihao, Zhou, Jianda, Li, Zhiyuan

“…Autism spectrum disorder (ASD) is a neurological disorder with complex etiologies. In this study, urine cells were collected from a 16-year-old male with ASD…”
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New strategy for high throughput screening of anti-influenza virus M2 ion channel inhibitors by Li, Chufang, Long, Yan, Lin, Zuoxian, Jie, Yanling, Xiao, Yajuan, Yang, Lingzhi, Sun, Juanjuan, Ren, Yizhong, Chen, Ling, Li, Zhiyuan

“…Since the recent emergence of swine and avian flu, there has been a sense of urgency to discover new anti-influenza drugs. In this study, a stable cell line…”
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Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma by Huang, Rongqi, Li, Shuai, Tian, Chao, Zhou, Peng, Zhao, Huifang, Xie, Wei, Xiao, Jie, Wang, Ling, Habimana, Jean de Dieu, Lin, Zuoxian, Yang, Yuchen, Cheng, Na, Li, Zhiyuan

“…Background The transient receptor potential vanilloid receptor 2 (TRPV2) has been found to participate in the pathogenesis of various types of cancers,…”
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Proarrhythmic effects induced by benzethonium chloride and domiphen bromide in vitro and in vivo by Long, Yan, Hou, Jian, Tang, Feng, Lin, Zuoxian, Huang, Xiaolin, Li, Wei, Chen, Yili, Li, Zhiyuan, Wu, Zhongkai

“…Benzethonium chloride (BZT) and domiphen bromide (DMP) are widely used as antimicrobials in drugs, vaccines and industry. However, no cardiac safety data has…”
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Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide by Long, Yan, Chen, Wanjuan, Lin, Zuoxian, Sun, Hongmao, Xia, Menghang, Zheng, Wei, Li, Zhiyuan

“…Domiphen bromide and didecyl dimethylammonium bromide were widely used environmental chemicals with potent activity on blockade of human ether-a-go-go related…”
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