Search Results - "Lin, Zhen Yuan"

Identification and functional characterization of transcriptional activators in human cells by Alerasool, Nader, Leng, He, Lin, Zhen-Yuan, Gingras, Anne-Claude, Taipale, Mikko

“…Transcription is orchestrated by thousands of transcription factors (TFs) and chromatin-associated proteins, but how these are causally connected to…”
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A High-Density Human Mitochondrial Proximity Interaction Network by Antonicka, Hana, Lin, Zhen-Yuan, Janer, Alexandre, Aaltonen, Mari J., Weraarpachai, Woranontee, Gingras, Anne-Claude, Shoubridge, Eric A.

“…We used BioID, a proximity-dependent biotinylation assay with 100 mitochondrial baits from all mitochondrial sub-compartments, to create a high-resolution…”
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SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome by Janer, Alexandre, Prudent, Julien, Paupe, Vincent, Fahiminiya, Somayyeh, Majewski, Jacek, Sgarioto, Nicolas, Des Rosiers, Christine, Forest, Anik, Lin, Zhen‐Yuan, Gingras, Anne‐Claude, Mitchell, Grant, McBride, Heidi M, Shoubridge, Eric A

“…Mitochondria form a dynamic network that responds to physiological signals and metabolic stresses by altering the balance between fusion and fission…”
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A pseudouridine synthase module is essential for mitochondrial protein synthesis and cell viability by Antonicka, Hana, Choquet, Karine, Lin, Zhen‐Yuan, Gingras, Anne‐Claude, Kleinman, Claudia L, Shoubridge, Eric A

“…Pseudouridylation is a common post‐transcriptional modification in RNA, but its functional consequences at the cellular level remain largely unknown. Using a…”
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A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways by Taipale, Mikko, Tucker, George, Peng, Jian, Krykbaeva, Irina, Lin, Zhen-Yuan, Larsen, Brett, Choi, Hyungwon, Berger, Bonnie, Gingras, Anne-Claude, Lindquist, Susan

“…Chaperones are abundant cellular proteins that promote the folding and function of their substrate proteins (clients). In vivo, chaperones also associate with…”
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An alternative splicing event amplifies evolutionary differences between vertebrates by Gueroussov, Serge, Gonatopoulos-Pournatzis, Thomas, Irimia, Manuel, Raj, Bushra, Lin, Zhen-Yuan, Gingras, Anne-Claude, Blencowe, Benjamin J.

“…Alternative splicing (AS) generates extensive transcriptomic and proteomic complexity. However, the functions of species- and lineage-specific splice variants…”
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Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms by Bagci, Halil, Sriskandarajah, Neera, Robert, Amélie, Boulais, Jonathan, Elkholi, Islam E., Tran, Viviane, Lin, Zhen-Yuan, Thibault, Marie-Pier, Dubé, Nadia, Faubert, Denis, Hipfner, David R., Gingras, Anne-Claude, Côté, Jean-François

“…Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding…”
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Global Protein Kinase and Phosphatase Interaction Network in Yeast by Breitkreutz, Ashton, Choi, Hyungwon, Sharom, Jeffrey R, Boucher, Lorrie, Neduva, Victor, Larsen, Brett, Lin, Zhen-Yuan, Breitkreutz, Bobby-Joe, Stark, Chris, Liu, Guomin, Ahn, Jessica, Dewar-Darch, Danielle, Reguly, Teresa, Tang, Xiaojing, Almeida, Ricardo, Qin, Zhaohui Steve, Pawson, Tony, Gingras, Anne-Claude, Nesvizhskii, Alexey I, Tyers, Mike

“…The interactions of protein kinases and phosphatases with their regulatory subunits and substrates underpin cellular regulation. We identified a kinase and…”
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A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface by Gupta, Gagan D., Coyaud, Étienne, Gonçalves, João, Mojarad, Bahareh A., Liu, Yi, Wu, Qianzhu, Gheiratmand, Ladan, Comartin, David, Tkach, Johnny M., Cheung, Sally W.T., Bashkurov, Mikhail, Hasegan, Monica, Knight, James D., Lin, Zhen-Yuan, Schueler, Markus, Hildebrandt, Friedhelm, Moffat, Jason, Gingras, Anne-Claude, Raught, Brian, Pelletier, Laurence

“…The centrosome is the primary microtubule organizing center of the cells and templates the formation of cilia, thereby operating at a nexus of…”
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Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains by Lambert, Jean-Philippe, Picaud, Sarah, Fujisawa, Takao, Hou, Huayun, Savitsky, Pavel, Uusküla-Reimand, Liis, Gupta, Gagan D., Abdouni, Hala, Lin, Zhen-Yuan, Tucholska, Monika, Knight, James D.R., Gonzalez-Badillo, Beatriz, St-Denis, Nicole, Newman, Joseph A., Stucki, Manuel, Pelletier, Laurence, Bandeira, Nuno, Wilson, Michael D., Filippakopoulos, Panagis, Gingras, Anne-Claude

“…Targeting bromodomains (BRDs) of the bromo-and-extra-terminal (BET) family offers opportunities for therapeutic intervention in cancer and other diseases…”
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Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions by Couzens, Amber L, Knight, James D R, Kean, Michelle J, Teo, Guoci, Weiss, Alexander, Dunham, Wade H, Lin, Zhen-Yuan, Bagshaw, Richard D, Sicheri, Frank, Pawson, Tony, Wrana, Jeffrey L, Choi, Hyungwon, Gingras, Anne-Claude

“…The Hippo pathway regulates organ size and tissue homeostasis in response to multiple stimuli, including cell density and mechanotransduction. Pharmacological…”
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Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets by Fu, Ci, Zhang, Xiang, Veri, Amanda O., Iyer, Kali R., Lash, Emma, Xue, Alice, Yan, Huijuan, Revie, Nicole M., Wong, Cassandra, Lin, Zhen-Yuan, Polvi, Elizabeth J., Liston, Sean D., VanderSluis, Benjamin, Hou, Jing, Yashiroda, Yoko, Gingras, Anne-Claude, Boone, Charles, O’Meara, Teresa R., O’Meara, Matthew J., Noble, Suzanne, Robbins, Nicole, Myers, Chad L., Cowen, Leah E.

“…Fungal pathogens pose a global threat to human health, with Candida albicans among the leading killers. Systematic analysis of essential genes provides a…”
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Global Gene Deletion Analysis Exploring Yeast Filamentous Growth by Ryan, Owen, Shapiro, Rebecca S., Kurat, Christoph F., Mayhew, David, Baryshnikova, Anastasia, Chin, Brian, Lin, Zhen-Yuan, Cox, Michael J., Vizeacoumar, Frederick, Cheung, Doris, Bahr, Sondra, Tsui, Kyle, Tebbji, Faiza, Sellam, Adnane, Istel, Fabian, Schwarzmüller, Tobias, Reynolds, Todd B., Kuchler, Karl, Gifford, David K., Whiteway, Malcolm, Giaever, Guri, Nislow, Corey, Costanzo, Michael, Gingras, Anne-Claude, Mitra, Robi David, Andrews, Brenda, Fink, Gerald R., Cowan, Leah E., Boone, Charles

“…The dimorphic switch from a single-cell budding yeast to a filamentous form enables Saccharomyces cerevisiae to forage for nutrients and the opportunistic…”
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Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns by Barutcu, A. Rasim, Wu, Mingkun, Braunschweig, Ulrich, Dyakov, Boris J.A., Luo, Zheng, Turner, Kyle M., Durbic, Tanja, Lin, Zhen-Yuan, Weatheritt, Robert J., Maass, Philipp G., Gingras, Anne-Claude, Blencowe, Benjamin J.

“…The nucleus is highly compartmentalized through the formation of distinct classes of membraneless domains. However, the composition and function of many of…”
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Global proteomic analyses define an environmentally contingent Hsp90 interactome and reveal chaperone-dependent regulation of stress granule proteins and the R2TP complex in a fungal pathogen by O'Meara, Teresa R, O'Meara, Matthew J, Polvi, Elizabeth J, Pourhaghighi, M Reza, Liston, Sean D, Lin, Zhen-Yuan, Veri, Amanda O, Emili, Andrew, Gingras, Anne-Claude, Cowen, Leah E

“…Hsp90 is a conserved molecular chaperone that assists in the folding and function of diverse cellular regulators, with a profound impact on biology, disease,…”
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HELB Is a Feedback Inhibitor of DNA End Resection by Tkáč, Ján, Xu, Guotai, Adhikary, Hemanta, Young, Jordan T.F., Gallo, David, Escribano-Díaz, Cristina, Krietsch, Jana, Orthwein, Alexandre, Munro, Meagan, Sol, Wendy, Al-Hakim, Abdallah, Lin, Zhen-Yuan, Jonkers, Jos, Borst, Piet, Brown, Grant W., Gingras, Anne-Claude, Rottenberg, Sven, Masson, Jean-Yves, Durocher, Daniel

“…DNA double-strand break repair by homologous recombination is initiated by the formation of 3′ single-stranded DNA (ssDNA) overhangs by a process termed end…”
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TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex by Merritt, Nicole, Garcia, Keith, Rajendran, Dushyandi, Lin, Zhen-Yuan, Zhang, Xiaomeng, Mitchell, Katrina M, Borcherding, Nicholas, Fullenkamp, Colleen, Chimenti, Michael S, Gingras, Anne-Claude, Harvey, Kieran F, Tanas, Munir R

“…Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma that metastasizes early in its clinical course and lacks an effective medical therapy. The…”
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A Global Regulatory Mechanism for Activating an Exon Network Required for Neurogenesis by Raj, Bushra, Irimia, Manuel, Braunschweig, Ulrich, Sterne-Weiler, Timothy, O’Hanlon, Dave, Lin, Zhen-Yuan, Chen, Ginny I., Easton, Laura E., Ule, Jernej, Gingras, Anne-Claude, Eyras, Eduardo, Blencowe, Benjamin J.

“…The vertebrate and neural-specific Ser/Arg (SR)-related protein nSR100/SRRM4 regulates an extensive program of alternative splicing with critical roles in…”
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ProHits: integrated software for mass spectrometry-based interaction proteomics by Tyers, Mike, Gingras, Anne-Claude, Liu, Guomin, Zhang, Jianping, Larsen, Brett, Stark, Chris, Breitkreutz, Ashton, Lin, Zhen-Yuan, Breitkreutz, Bobby-Joe, Ding, Yongmei, Colwill, Karen, Pasculescu, Adrian, Pawson, Tony, Wrana, Jeffrey L, Nesvizhskii, Alexey I, Raught, Brian

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Functional divergence of a global regulatory complex governing fungal filamentation by Polvi, Elizabeth J, Veri, Amanda O, Liu, Zhongle, Hossain, Saif, Hyde, Sabrina, Kim, Sang Hu, Tebbji, Faiza, Sellam, Adnane, Todd, Robert T, Xie, Jinglin L, Lin, Zhen-Yuan, Wong, Cassandra J, Shapiro, Rebecca S, Whiteway, Malcolm, Robbins, Nicole, Gingras, Anne-Claude, Selmecki, Anna, Cowen, Leah E

“…Morphogenetic transitions are prevalent in the fungal kingdom. For a leading human fungal pathogen, Candida albicans, the capacity to transition between yeast…”
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