Search Results - "Lin, Yingqi"

CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms by Tu, Zhuchi, Zhao, Hui, Li, Bang, Yan, Sen, Wang, Lu, Tang, Yongjin, Li, Zhujun, Bai, Dazhang, Li, Caijuan, Lin, Yingqi, Li, Yuefeng, Liu, Jianrong, Xu, Hao, Guo, Xiangyu, Jiang, Yong-hui, Zhang, Yong Q, Li, Xiao-Jiang

“…Abstract Monogenic mutations in the SHANK3 gene, which encodes a postsynaptic scaffold protein, play a causative role in autism spectrum disorder (ASD)…”
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Progress in high-performance stick-slip piezoelectric actuators: a review by Lin, Yingqi, An, Dawei, Lin, Zhenyu, Chen, Xiaoting, Huang, Weiqing

“…The ultra-precision field is popular for its micro-nanometer positioning accuracy and large working stroke. Piezoelectric actuators based on the stick-slip…”
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Application of CRISPR/Cas9 System in Establishing Large Animal Models by Lin, Yingqi, Li, Jun, Li, Caijuan, Tu, Zhuchi, Li, Shihua, Li, Xiao-Jiang, Yan, Sen

“…The foundation for investigating the mechanisms of human diseases is the establishment of animal models, which are also widely used in agricultural industry,…”
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A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin by Li, Caijuan, Lin, Yingqi, Chen, Yizhi, Song, Xichen, Zheng, Xiao, Li, Jiawei, He, Jun, Chen, Xiusheng, Huang, Chunhui, Wang, Wei, Wu, Jianhao, Wu, Jiaxi, Gao, Jiale, Tu, Zhuchi, Li, Xiao‐Jiang, Yan, Sen, Li, Shihua

“…Abstract Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington's…”
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Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys by Tu, Zhuchi, Yan, Sen, Han, Bofeng, Li, Caijuan, Liang, Weien, Lin, Yingqi, Ding, Yongyan, Wei, Huiyi, Wang, Lu, Xu, Hao, Ye, Jianmeng, Li, Bang, Li, Shihua, Li, Xiao-Jiang

“…Tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of Aβ oligomers,…”
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Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing by Zheng, Xiao, Huang, Chunhui, Lin, Yingqi, Han, Bofeng, Chen, Yizhi, Li, Caijuan, Li, Jiawei, Ding, Yongyan, Song, Xichen, Wang, Wei, Liang, Weien, Wu, Jianhao, Wu, Jiaxi, Gao, Jiale, Wei, Chengxi, Zhang, Xudong, Tu, Zhuchi, Yan, Sen

“…Severe combined immunodeficiency (SCID) encompasses a range of inherited disorders that lead to a profound deterioration of the immune system. Among the…”
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Intravenous AAV9 administration results in safe and widespread distribution of transgene in the brain of mini-pig by Lin, Yingqi, Li, Caijuan, Wang, Wei, Li, Jiawei, Huang, Chunhui, Zheng, Xiao, Liu, Zhaoming, Song, Xichen, Chen, Yizhi, Gao, Jiale, Wu, Jianhao, Wu, Jiaxi, Tu, Zhuchi, Lai, Liangxue, Li, Xiao-Jiang, Li, Shihua, Yan, Sen

“…Animal models are important for understanding the pathogenesis of human diseases and for developing and testing new drugs. Pigs have been widely used in the…”
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Biophysical and X-ray structural studies of the (GGGTT)3GGG G-quadruplex in complex with N-methyl mesoporphyrin IX by Lin, Linda Yingqi, McCarthy, Sawyer, Powell, Barrett M, Manurung, Yanti, Xiang, Irene M, Dean, William L, Chaires, Brad, Yatsunyk, Liliya A

“…The G-quadruplex (GQ) is a well-studied non-canonical DNA structure formed by G-rich sequences found at telomeres and gene promoters. Biological studies…”
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Biophysical and X-ray structural studies of the (GGGTT)3GGG G-quadruplex in complex with N-methyl mesoporphyrin IX by Lin, Linda Yingqi, McCarthy, Sawyer, Powell, Barrett M., Manurung, Yanti, Xiang, Irene M., Dean, William L., Chaires, Brad, Yatsunyk, Liliya A., Ouellette, ed., Michel M.

“…The G-quadruplex (GQ) is a well-studied non-canonical DNA structure formed by G-rich sequences found at telomeres and gene promoters. Biological studies…”
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Spectrum sharing mechanisms in the unlicensed band: Performance limit and comparison by Lin, Yingqi, Sun, Xinghua, Gao, Yayu, Zhan, Wen, Li, Yitong

“…Deploying networks in unlicensed spectrum has been drawing significant attention, which serves to alleviate the increasing demands in licensed spectrum…”
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Multifunctional Theranostic 2D Vanadium Carbidel for Enhanced Cancer Immunotherapy by Feng, Keke, Li, Chenglei, Xiong, Rui, Lin, Yingqi, Cui, Zhou, Tu, Yifan, Zhang, Mingzhe, Sa, Baisheng, Shao, Jingwei

“…The application of 2D MXene materials in the biomedical field has been widely explored. Apart from excellent photothermal properties, their role in modulating…”
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Fair and Efficient Spectrum Sharing in Unlicensed Bands: Does Number of Links Matter? by Lin, Yingqi, Sun, Xinghua, Gao, Yayu, Zhan, Wen, Wang, Xijun, Chen, Xiang

“…The rapid growth of mobile data traffic has become a great challenge to the licensed spectrum in scarcity. Driven by this, deploying networks in unlicensed…”
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Systematic Identification of Novel Ferroptosis-Associated Multigene Models for Predicting Patient Prognosis Based on Endometrial Cancer by Liu, Xiqin, Lin, Yingqi, Liu, Xiaoling, Han, Xia, Wu, Jia

“…Objective. Uterine corpus endometrial carcinoma (UCEC) is a frequent epithelial cancer in females. The rate of UCEC occurrence increases year by year and the…”
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TBN improves motor function and prolongs survival in a TDP-43M337V mouse model of ALS by Huang, Chunhui, Li, Jun, Zhang, Guiliang, Lin, Yingqi, Li, Caijuan, Zheng, Xiao, Song, Xichen, Han, Bofeng, Guo, Baojian, Tu, Zhuchi, Zhang, Jun, Sun, Yewei, Wang, Yuqiang, Zhang, Zaijun, Yan, Sen

“…Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are serious neurodegenerative diseases. Although their pathogenesis is…”
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Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease by Yan, Sen, Zheng, Xiao, Lin, Yingqi, Li, Caijuan, Liu, Zhaoming, Li, Jiawei, Tu, Zhuchi, Zhao, Yu, Huang, Chunhui, Chen, Yizhi, Li, Jun, Song, Xichen, Han, Bofeng, Wang, Wei, Liang, Weien, Lai, Liangxue, Li, Xiao-Jiang, Li, Shihua

“…The monogenic nature of Huntington’s disease (HD) and other neurodegenerative diseases caused by the expansion of glutamine-encoding CAG repeats makes them…”
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A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin (Adv. Sci. 31/2023) by Li, Caijuan, Lin, Yingqi, Chen, Yizhi, Song, Xichen, Zheng, Xiao, Li, Jiawei, He, Jun, Chen, Xiusheng, Huang, Chunhui, Wang, Wei, Wu, Jianhao, Wu, Jiaxi, Gao, Jiale, Tu, Zhuchi, Li, Xiao‐Jiang, Yan, Sen, Li, Shihua

“…Lysosome In article number 2301120 , Xiao‐Jiang Li, Sen Yan, Shihua Li, and their colleagues utilized a small intrabody peptide linked to lysosomes to…”
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Geometric-Aware Low-Light Image and Video Enhancement via Depth Guidance by Lin, Yingqi, Xu, Xiaogang, Han, Yan, Wu, Jiafei, Liu, Zhe

“…Low-Light Enhancement (LLE) is aimed at improving the quality of photos/videos captured under low-light conditions. It is worth noting that most existing LLE…”
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Video Frame Interpolation with Region-Distinguishable Priors from SAM by Han, Yan, Xu, Xiaogang, Lin, Yingqi, Wu, Jiafei, Liu, Zhe

“…In existing Video Frame Interpolation (VFI) approaches, the motion estimation between neighboring frames plays a crucial role. However, the estimation accuracy…”
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Human genetic diversity alters off-target outcomes of therapeutic gene editing by Cancellieri, Samuele, Zeng, Jing, Lin, Linda Yingqi, Tognon, Manuel, Nguyen, My Anh, Lin, Jiecong, Bombieri, Nicola, Maitland, Stacy A., Ciuculescu, Marioara-Felicia, Katta, Varun, Tsai, Shengdar Q., Armant, Myriam, Wolfe, Scot A., Giugno, Rosalba, Bauer, Daniel E., Pinello, Luca

“…CRISPR gene editing holds great promise to modify DNA sequences in somatic cells to treat disease. However, standard computational and biochemical methods to…”
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Distinguish Any Fake Videos: Unleashing the Power of Large-scale Data and Motion Features by Ji, Lichuan, Lin, Yingqi, Huang, Zhenhua, Han, Yan, Xu, Xiaogang, Wu, Jiafei, Wang, Chong, Liu, Zhe

“…The development of AI-Generated Content (AIGC) has empowered the creation of remarkably realistic AI-generated videos, such as those involving Sora. However,…”
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