Search Results - "Lin, Xianchai"
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Inhibition of pirfenidone on TGF-beta2 induced proliferation, migration and epithlial-mesenchymal transition of human lens epithelial cells line SRA01/04
Published in PloS one (21-02-2013)“…Posterior capsular opacification (PCO) is a common complication of cataract surgery. Transforming growth factor-β2 (TGF-β2) plays important roles in the…”
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Effects of Pirfenidone on Proliferation, Migration, and Collagen Contraction of Human Tenon's Fibroblasts In Vitro
Published in Investigative ophthalmology & visual science (01-08-2009)“…To investigate the effect of pirfenidone, a novel antifibrotic agent, on proliferation, migration, and collagen contraction of human Tenon's fibroblasts…”
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Preoperative Expectations and Postoperative Outcomes of Visual Functioning among Cataract Patients in Urban Southern China
Published in PloS one (09-01-2017)“…To investigate the relationship between preoperative expectations and actual postoperative outcomes of visual function (VF) among patients undergoing first eye…”
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Prevalence of and risk factors for pterygium in rural adult chinese populations of the Bai nationality in Dali: the Yunnan Minority Eye Study
Published in Investigative ophthalmology & visual science (25-09-2012)“…The purpose of the study was to describe the prevalence, severity, and associated risk factors for pterygium in a population-based sample of rural residents of…”
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Rasch analysis of the hospital anxiety and depression scale among Chinese cataract patients
Published in PloS one (26-09-2017)“…To analyze the validity of the Hospital Anxiety and Depression Scale (HADS) among Chinese cataract population. A total of 275 participants with unilateral or…”
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Deciphering the impact of aging on splenic endothelial cell heterogeneity and immunosenescence through single-cell RNA sequencing analysis
Published in Immunity & ageing (18-07-2024)“…Aging is associated with significant structural and functional changes in the spleen, leading to immunosenescence, yet the detailed effects on splenic vascular…”
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PDGF-D-induced immunoproteasome activation and cell-cell interactions
Published in Computational and structural biotechnology journal (01-01-2023)“…Platelet-derived growth factor-D (PDGF-D) is abundantly expressed in ocular diseases. Yet, it remains unknown whether and how PDGF-D affects ocular cells or…”
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Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK
Published in Proceedings of the National Academy of Sciences - PNAS (03-10-2017)“…Ocular neovascularization is a devastating pathology of numerous ocular diseases and is a major cause of blindness. Caveolin-1 (Cav-1) plays important roles in…”
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Single-cell chromatin accessibility and transcriptomic characterization of Behcet’s disease
Published in Communications biology (17-10-2023)“…Behect’s disease is a chronic vasculitis characterized by complex multi-organ immune aberrations. However, a comprehensive understanding of the gene-regulatory…”
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Validation of Catquest-9SF questionnaire in a Chinese cataract population
Published in PloS one (01-08-2014)“…To develop and validate a Chinese version of the Catquest-9SF questionnaire in a cataract population. The Catquest-9SF Questionnaire was translated and back…”
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Health literacy, computer skills and quality of patient-physician communication in Chinese patients with cataract
Published in PloS one (2014)“…The aim of the study was to assess levels of health literacy and computer skills in Chinese patients with cataract, and their impact on the doctor-patient…”
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Recommendation on data collection and annotation of ocular appearance images in ptosis
Published in Intelligent medicine (01-11-2023)“…Ptosis is a common ophthalmologic condition, and the diagnosis is primarily based on ocular appearance. The diagnosis of such conditions can be improved using…”
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13
VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway
Published in Signal transduction and targeted therapy (18-08-2023)“…Although VEGF-B was discovered as a VEGF-A homolog a long time ago, the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings…”
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14
CD169+ classical monocyte as an important participant in Graves’ ophthalmopathy through CXCL12-CXCR4 axis
Published in iScience (15-03-2024)“…Patients with Graves’ disease (GD) can develop Graves’ ophthalmopathy (GO), but the underlying pathological mechanisms driving this development remain unclear…”
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Platelet-Derived Growth Factor-D Activates Complement System to Propagate Macrophage Polarization and Neovascularization
Published in Frontiers in cell and developmental biology (02-06-2021)“…Platelet-derived growth factor-D (PDGF-D) is highly expressed in immune cells. However, the potential role of PDGF-D in immune system remains thus far unclear…”
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Mitogen-Inducible Gene 6 Inhibits Angiogenesis by Binding to SHC1 and Suppressing Its Phosphorylation
Published in Frontiers in cell and developmental biology (22-02-2021)“…The mitogen-inducible gene 6 (MIG6) is an adaptor protein widely expressed in vascular endothelial cells. However, it remains unknown thus far whether it plays…”
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Corrigendum: Platelet-Derived Growth Factor-D Activates Complement System to Propagate Macrophage Polarization and Neovascularization
Published in Frontiers in cell and developmental biology (08-02-2022)“…[This corrects the article DOI: 10.3389/fcell.2021.686886.]…”
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Pronounced Conjunctival Vascular Engorgement in Von Hippel-Lindau Syndrome
Published in Ophthalmology (Rochester, Minn.) (06-07-2024)Get full text
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Single-cell analysis of immune cells on gingiva-derived mesenchymal stem cells in experimental autoimmune uveitis
Published in iScience (19-05-2023)“…Gingiva-derived mesenchymal stem cells (GMSCs) have shown astonishing efficacy in the treatment of various autoimmune diseases. However, the mechanisms…”
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Association of CYP2D6 single-nucleotide polymorphism with response to ophthalmic timolol in primary open-angle Glaucoma--a pilot study
Published in Journal of ocular pharmacology and therapeutics (01-10-2010)“…We aimed to investigate whether CYP2D6 polymorphisms were associated with the intraocular pressure (IOP)-lowering effect and systemic complications (especially…”
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