Search Results - "Lin, Wen‐Jye"

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    Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2‐induced STAT3 activation by Izumi, Kouji, Fang, Lei‐Ya, Mizokami, Atsushi, Namiki, Mikio, Li, Lei, Lin, WenJye, Chang, Chawnshang

    Published in EMBO molecular medicine (01-09-2013)
    “…Increased CCL2 expression in prostate cancer (PCa) cells enhanced metastasis via macrophage recruitment. However, its linkage to androgen receptor…”
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    CCL2 induces resistance to the antiproliferative effect of cabazitaxel in prostate cancer cells by Natsagdorj, Ariunbold, Izumi, Kouji, Hiratsuka, Kaoru, Machioka, Kazuaki, Iwamoto, Hiroaki, Naito, Renato, Makino, Tomoyuki, Kadomoto, Suguru, Shigehara, Kazuyoshi, Kadono, Yoshifumi, Lin, WenJye, Maolake, Aerken, Mizokami, Atsushi

    Published in Cancer science (01-01-2019)
    “…Understanding the mechanism of chemoresistance and disease progression in patients with prostate cancer is important for developing novel treatment strategies…”
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    Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22-CCR4 axis by Maolake, Aerken, Izumi, Kouji, Shigehara, Kazuyoshi, Natsagdorj, Ariunbold, Iwamoto, Hiroaki, Kadomoto, Suguru, Takezawa, Yuta, Machioka, Kazuaki, Narimoto, Kazutaka, Namiki, Mikio, Lin, Wen-Jye, Wufuer, Guzailinuer, Mizokami, Atsushi

    Published in Oncotarget (07-02-2017)
    “…Previous studies have found that tumor-associated macrophages (TAMs) promote cancer progression. We previously reported that TAMs promote prostate cancer…”
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    Infiltrating Macrophages Promote Prostate Tumorigenesis via Modulating Androgen Receptor-Mediated CCL4-STAT3 Signaling by FANG, Lei-Ya, IZUMI, Kouji, LAI, Kuo-Pao, LIANG LIANG, LEI LI, MIYAMOTO, Hiroshi, LIN, Wen-Jye, CHAWNSHANG CHANG

    Published in Cancer research (Chicago, Ill.) (15-09-2013)
    “…Infiltrating macrophages are a key component of inflammation during tumorigenesis, but the direct evidence of such linkage remains unclear. We report here that…”
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    DUSP22 suppresses prostate cancer proliferation by targeting the EGFR‐AR axis by Lin, Hsiu‐Ping, Ho, Hui‐Min, Chang, Cheng‐Wei, Yeh, Shauh‐Der, Su, Yu‐Wen, Tan, Tse‐Hua, Lin, WenJye

    Published in The FASEB journal (01-12-2019)
    “…Dual‐specificity phosphatases (DUSPs) regulate the activity of various downstream kinases through serine or threonine or tyrosine dephosphorylation. Loss of…”
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    PP4 deficiency leads to DNA replication stress that impairs immunoglobulin class switch efficiency by Chen, Ming-Yu, Hsu, Wei-Chan, Hsu, Shu-Ching, Yang, Yu-Shao, Chuang, Tsung-Hsien, Lin, Wen-Jye, Tan, Tse-Hua, Su, Yu-Wen

    Published in Cell death and differentiation (01-07-2019)
    “…The serine/threonine phosphatase PP4 has been implicated in DNA damage repair and cell cycle regulation through its dephosphorylation of specific substrates…”
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    C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a by Yeh, Wen-Chen, Chen, Nien-Jung, Mirtsos, Christine, Suh, Daniel, Lu, Yong-Chen, Lin, Wen-Jye, McKerlie, Colin, Lee, Taeweon, Baribault, Helene, Tian, Hui

    Published in Nature (08-03-2007)
    “…Complement-derived anaphylatoxins regulate immune and inflammatory responses through G-protein-coupled receptor (GPCR)-mediated signalling. C5L2 (also known as…”
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    Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFκB2 signaling that contributes to autoimmunity by Lin, Wen-Jye, Su, Yu-Wen, Lu, Yong-Chen, Hao, Zhenyue, Chio, Iok In Christine, Chen, Nien-Jung, Brüstle, Anne, Li, Wanda Y, Mak, Tak Wah

    “…TNF receptor-associated factor 2 (TRAF2) is a key intracellular signaling mediator that acts downstream of not only TNFα but also various members of the TNFα…”
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    PP4 is essential for germinal center formation and class switch recombination in mice by Chen, Ming-Yu, Chen, Ya-Ping, Wu, Ming-Sian, Yu, Guanni-Yi, Lin, Wen-Jye, Tan, Tse-Hua, Su, Yu-Wen

    Published in PloS one (12-09-2014)
    “…PP4 is a serine/threonine phosphatase required for immunoglobulin (Ig) VDJ recombination and pro-B/pre-B cell development in mice. To elucidate the role of PP4…”
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    Loss of TR4 Orphan Nuclear Receptor Reduces Phosphoenolpyruvate Carboxykinase–Mediated Gluconeogenesis by LIU, Ning-Chun, LIN, Wen-Jye, KIM, Eungseok, COLLINS, Loretta L, LIN, Hung-Yun, YU, I-Chen, SPARKS, Janet D, CHEN, Lu-Min, LEE, Yi-Fen, CHANG, Chawnshang

    Published in Diabetes (New York, N.Y.) (01-12-2007)
    “…Loss of TR4 Orphan Nuclear Receptor Reduces Phosphoenolpyruvate Carboxykinase–Mediated Gluconeogenesis Ning-Chun Liu 1 , Wen-Jye Lin 1 , Eungseok Kim 1 2 ,…”
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    14-3-3σ regulates B-cell homeostasis through stabilization of FOXO1 by Su, Yu-Wen, Hao, Zhenyue, Hirao, Atsushi, Yamamoto, Kazuo, Lin, Wen-Jye, Young, Ashley, Duncan, Gordon S, Yoshida, Hiroki, Wakeham, Andrew, Lang, Philipp A, Murakami, Kiichi, Ohashi, Pamela, Mak, Tak W

    “…14-3-3σ regulates cytokinesis and cell cycle arrest induced by DNA damage but its role in the immune system is unknown. Using gene-targeted 14-3-3σ-deficient…”
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    Androgen Receptor Roles in the Development of Benign Prostate Hyperplasia by Izumi, Kouji, Mizokami, Atsushi, Lin, Wen-Jye, Lai, Kuo-Pao, Chang, Chawnshang

    Published in The American journal of pathology (01-06-2013)
    “…Benign prostate hyperplasia (BPH) is a major cause of lower urinary tract symptoms, with an increased volume of transitional zone and associated with increased…”
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    Proteasome Activity Is Required for Androgen Receptor Transcriptional Activity via Regulation of Androgen Receptor Nuclear Translocation and Interaction with Coregulators in Prostate Cancer Cells by Lin, Hui-Kuan, Altuwaijri, Saleh, Lin, Wen-Jye, Kan, Pu-Yeh, Collins, Loretta L., Chang, Chawnshang

    Published in The Journal of biological chemistry (27-09-2002)
    “…Upon binding to androgen, the androgen receptor (AR) can translocate into the nucleus and bind to androgen response element(s) to modulate its target genes…”
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    Differential Modulation of Androgen Receptor-mediated Transactivation by Smad3 and Tumor Suppressor Smad4 by Kang, Hong-Yo, Huang, Ko-En, Chang, Shiuh Young, Ma, Wen-Lung, Lin, Wen-Jye, Chang, Chawnshang

    Published in The Journal of biological chemistry (15-11-2002)
    “…Smad proteins have been demonstrated to be key components in the transforming growth factor β signaling cascade. Here we demonstrate that Smad4, together with…”
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    Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression by Lai, Jiann-Jyh, Lai, Kuo-Pao, Chuang, Kuang-Hsiang, Chang, Philip, Yu, I-Chen, Lin, Wen-Jye, Chang, Chawnshang

    Published in The Journal of clinical investigation (01-12-2009)
    “…Cutaneous wounds heal more slowly in elderly males than in elderly females, suggesting a role for sex hormones in the healing process. Indeed,…”
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