Search Results - "Lin, Wen‐Jye"
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Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2‐induced STAT3 activation
Published in EMBO molecular medicine (01-09-2013)“…Increased CCL2 expression in prostate cancer (PCa) cells enhanced metastasis via macrophage recruitment. However, its linkage to androgen receptor…”
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CCL2 induces resistance to the antiproliferative effect of cabazitaxel in prostate cancer cells
Published in Cancer science (01-01-2019)“…Understanding the mechanism of chemoresistance and disease progression in patients with prostate cancer is important for developing novel treatment strategies…”
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Suppression of androgen receptor signaling induces prostate cancer migration via activation of the CCL20–CCR6 axis
Published in Cancer science (01-04-2023)“…The suppression of androgen receptor (AR) expression exacerbates the migration potential of prostate cancer. This study identified a previously unrecognized…”
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C‐C motif ligand 5 promotes migration of prostate cancer cells in the prostate cancer bone metastasis microenvironment
Published in Cancer science (01-03-2018)“…Chemokines and their receptors have key roles in cancer progression. The present study investigated chemokine activity in the prostate cancer bone metastasis…”
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5
Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22-CCR4 axis
Published in Oncotarget (07-02-2017)“…Previous studies have found that tumor-associated macrophages (TAMs) promote cancer progression. We previously reported that TAMs promote prostate cancer…”
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Infiltrating Macrophages Promote Prostate Tumorigenesis via Modulating Androgen Receptor-Mediated CCL4-STAT3 Signaling
Published in Cancer research (Chicago, Ill.) (15-09-2013)“…Infiltrating macrophages are a key component of inflammation during tumorigenesis, but the direct evidence of such linkage remains unclear. We report here that…”
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DUSP22 suppresses prostate cancer proliferation by targeting the EGFR‐AR axis
Published in The FASEB journal (01-12-2019)“…Dual‐specificity phosphatases (DUSPs) regulate the activity of various downstream kinases through serine or threonine or tyrosine dephosphorylation. Loss of…”
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PP4 deficiency leads to DNA replication stress that impairs immunoglobulin class switch efficiency
Published in Cell death and differentiation (01-07-2019)“…The serine/threonine phosphatase PP4 has been implicated in DNA damage repair and cell cycle regulation through its dephosphorylation of specific substrates…”
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C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a
Published in Nature (08-03-2007)“…Complement-derived anaphylatoxins regulate immune and inflammatory responses through G-protein-coupled receptor (GPCR)-mediated signalling. C5L2 (also known as…”
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10
Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFκB2 signaling that contributes to autoimmunity
Published in Proceedings of the National Academy of Sciences - PNAS (08-11-2011)“…TNF receptor-associated factor 2 (TRAF2) is a key intracellular signaling mediator that acts downstream of not only TNFα but also various members of the TNFα…”
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Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors
Published in Proceedings of the National Academy of Sciences - PNAS (26-08-2008)“…Tumor necrosis factor receptor 1-associated death domain protein (TRADD) is the core adaptor recruited to TNF receptor 1 (TNFR1) upon TNFα stimulation. In…”
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PP4 is essential for germinal center formation and class switch recombination in mice
Published in PloS one (12-09-2014)“…PP4 is a serine/threonine phosphatase required for immunoglobulin (Ig) VDJ recombination and pro-B/pre-B cell development in mice. To elucidate the role of PP4…”
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13
Loss of TR4 Orphan Nuclear Receptor Reduces Phosphoenolpyruvate Carboxykinase–Mediated Gluconeogenesis
Published in Diabetes (New York, N.Y.) (01-12-2007)“…Loss of TR4 Orphan Nuclear Receptor Reduces Phosphoenolpyruvate Carboxykinase–Mediated Gluconeogenesis Ning-Chun Liu 1 , Wen-Jye Lin 1 , Eungseok Kim 1 2 ,…”
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14-3-3σ regulates B-cell homeostasis through stabilization of FOXO1
Published in Proceedings of the National Academy of Sciences - PNAS (25-01-2011)“…14-3-3σ regulates cytokinesis and cell cycle arrest induced by DNA damage but its role in the immune system is unknown. Using gene-targeted 14-3-3σ-deficient…”
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Single-cell RNA sequencing uncovers the individual alteration of intestinal mucosal immunocytes in Dusp6 knockout mice
Published in iScience (18-02-2022)“…Single-cell RNA sequencing (scRNA-seq) approach can broadly and specifically evaluate the individual cells with minimum detection bias. To explore the…”
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Prognostic Significance of O-GlcNAc and PKM2 in Hormone Receptor-Positive and HER2-Nonenriched Breast Cancer
Published in Diagnostics (Basel) (01-08-2021)“…Predictive metabolic biomarkers for the recurrent luminal breast cancer (BC) with hormone receptor (HR)-positive and human epidermal growth factor receptor…”
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Androgen Receptor Roles in the Development of Benign Prostate Hyperplasia
Published in The American journal of pathology (01-06-2013)“…Benign prostate hyperplasia (BPH) is a major cause of lower urinary tract symptoms, with an increased volume of transitional zone and associated with increased…”
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Proteasome Activity Is Required for Androgen Receptor Transcriptional Activity via Regulation of Androgen Receptor Nuclear Translocation and Interaction with Coregulators in Prostate Cancer Cells
Published in The Journal of biological chemistry (27-09-2002)“…Upon binding to androgen, the androgen receptor (AR) can translocate into the nucleus and bind to androgen response element(s) to modulate its target genes…”
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Differential Modulation of Androgen Receptor-mediated Transactivation by Smad3 and Tumor Suppressor Smad4
Published in The Journal of biological chemistry (15-11-2002)“…Smad proteins have been demonstrated to be key components in the transforming growth factor β signaling cascade. Here we demonstrate that Smad4, together with…”
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Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression
Published in The Journal of clinical investigation (01-12-2009)“…Cutaneous wounds heal more slowly in elderly males than in elderly females, suggesting a role for sex hormones in the healing process. Indeed,…”
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