Search Results - "Lin, Wanhui"
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Predicting cognitive impairment in outpatients with epilepsy using machine learning techniques
Published in Scientific reports (08-10-2021)“…Many studies report predictions for cognitive function but there are few predictions in epileptic patients; therefore, we established a workflow to efficiently…”
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Factors for cognitive impairment in adult epileptic patients
Published in Brain and behavior (01-01-2020)“…Objective To analyze factors for cognitive impairment in epileptic patients. Methods A total of 257 epileptic patients completed clinical memory scale (CMS)…”
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Intrinsic brain activity differences in perampanel-responsive and non-responsive drug-resistant epilepsy patients: an EEG microstate analysis
Published in Therapeutic advances in neurological disorders (01-01-2024)“…Drug-resistant epilepsy (DRE) patients exhibit aberrant large-scale brain networks. Perampanel may be a therapeutic option for controlling seizures in these…”
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A nomogram to predict the treatment benefit of perampanel in drug-resistant epilepsy patients
Published in Frontiers in neurology (14-11-2023)“…The objective of this study was to identify the factors that affect the efficacy of added perampanel for the treatment of drug-resistant epilepsy (DRE), and to…”
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ADCY3: the pivotal gene in classical ketogenic diet for the treatment of epilepsy
Published in Frontiers in cellular neuroscience (22-05-2024)“…Epilepsy is a common neurological disorder characterized by recurrent epilepsy episodes. As a non-pharmacological treatment, the ketogenic diet has been widely…”
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A comprehensive prediction model of drug-refractory epilepsy based on combined clinical-EEG microstate features
Published in Therapeutic advances in neurological disorders (01-01-2024)“…Epilepsy is a chronic neurological disorder characterized by recurrent seizures that significantly impact patients' quality of life. Identifying predictors is…”
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Generation of an integration-free induced pluripotent stem cell line, FJMUUHi002-A, from a Rett syndrome patient with a heterozygous mutation p. R133C in MeCP2
Published in Stem cell research (01-02-2024)“…The human iPS cell line, hiPS-RTT (FJMUi002-A), is derived from peripheral blood mononuclear cells (PBMCs) from a 12-year-old female RTT patient carrying a…”
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Role of inflammatory cytokine in mediating the effect of plasma lipidome on epilepsy: a mediation Mendelian randomization study
Published in Frontiers in neurology (30-05-2024)“…Epilepsy is one of the most prevalent serious brain disorders globally, impacting over 70 million individuals. Observational studies have increasingly…”
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The Antagonism of 5-HT6 Receptor Attenuates Current-Induced Spikes and Improves Long-Term Potentiation via the Regulation of M-Currents in a Pilocarpine-Induced Epilepsy Model
Published in Frontiers in pharmacology (28-04-2020)“…Recent studies have documented that reduced M-current promotes epileptogenesis and attenuates synaptic remodeling. Neurite growth is closely related to the…”
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Sequencing of neurofilament genes identified NEFH Ser787Arg as a novel risk variant of sporadic amyotrophic lateral sclerosis in Chinese subjects
Published in BMC medical genomics (11-09-2021)“…Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with neuronal cell inclusions composed of neurofilaments and other abnormal…”
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The Role of 5-HTR6 in Mossy Fiber Sprouting: Activating Fyn and p-ERK1/2 in Pilocarpine-Induced Chronic Epileptic Rats
Published in Cellular physiology and biochemistry (01-01-2017)“…Objective: Our primary objective is to verify whether 5-HTR6 is involved in the development of mossy fiber sprouting (MFS), and to determine how the…”
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Continuous video electroencephalogram for herpes simplex encephalitis: a case report and literature review
Published in Acta epileptologica (29-07-2020)“…Background Electroencephalogram (EEG) is an important tool for the diagnosis of herpes simplex virus encephalitis (HSE). However, the diagnosis of…”
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A Ketogenic Diet Affects Gut Microbiota by Regulating Gut Microbiota and Promoting Hippocampal TRHR Expression to Combat Seizures
Published in Journal of molecular neuroscience (03-11-2024)“…With the persistent challenge that epilepsy presents to therapeutic avenues, the study seeks to decipher the effects of the ketogenic diet (KD) on gut…”
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EEG microstates in epilepsy with and without cognitive dysfunction: Alteration in intrinsic brain activity
Published in Epilepsy & behavior (01-05-2024)“…•Currently, there is no research focusing on the EEG microstates of epilepsy comorbid cognitive dysfunction.•Studies have shown that both cognitive dysfunction…”
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Relationship between resting state functional magnetic resonance imaging and memory function in mesial temporal lobe epilepsy
Published in Journal of the neurological sciences (15-01-2017)“…To study memory impairment mechanisms of the medial temporal lobe epilepsy (MTLE) by analyzing the functional connectivity (FC) through resting state…”
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Pharmacological inhibition of S6K1 rescues synaptic deficits and attenuates seizures and depression in chronic epileptic rats
Published in CNS neuroscience & therapeutics (01-03-2024)“…Background Recent studies have shown that mTOR signaling plays an important role in synaptic plasticity. However, the function of S6K1, the mechanistic target…”
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Over-expression of 5-HT6 Receptor and Activated Jab-1/p-c-Jun Play Important Roles in Pilocarpine-Induced Seizures and Learning-Memory Impairment
Published in Journal of molecular neuroscience (01-03-2019)“…Cognitive impairment is a common comorbidity in patients with temporal lobe epilepsy (TLE) that severely affects patients’ quality of life. Also, serotonin…”
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Relationship between r esting s tate f unctional m agnetic r esonance i maging and m emory f unction in m esial t emporal l obe e pilepsy
Published in Journal of the neurological sciences (2016)“…Abstract Object To study memory impairment mechanisms of the medial temporal lobe epilepsy (MTLE) by analyzing the functional connectivity (FC) through resting…”
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Case Report: Recognition of Devastating Primary Amoebic Meningoencephalitis (PAM) Caused by Naegleria fowleri: Another Case in South China Detected via Metagenomics Next-Generation Sequencing Combined With Microscopy and a Review
Published in Frontiers in tropical diseases (18-08-2022)Get full text
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