Search Results - "Lin, Wan Hsin"

Brain metastases-derived extracellular vesicles induce binding and aggregation of low-density lipoprotein by Busatto, Sara, Yang, Yubo, Walker, Sierra A, Davidovich, Irina, Lin, Wan-Hsin, Lewis-Tuffin, Laura, Anastasiadis, Panagiotis Z, Sarkaria, Jann, Talmon, Yeshayahu, Wurtz, Gregory, Wolfram, Joy

“…Cancer cell-derived extracellular vesicles (EVs) have previously been shown to contribute to pre-metastatic niche formation. Specifically, aggressive tumors…”
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Establishment of epithelial polarity--GEF who's minding the GAP? by Ngok, Siu P, Lin, Wan-Hsin, Anastasiadis, Panos Z

“…Cell polarization is a fundamental process that underlies epithelial morphogenesis, cell motility, cell division and organogenesis. Loss of polarity…”
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Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma by Boyd, Ryan J., Olson, Tien L., Zook, James D., Stein, Derek, Aceves, Manuel, Lin, Wan‐Hsin, Craciunescu, Felicia M., Hansen, Debra T., Anastasiadis, Panos Z., Singharoy, Abhishek, Fromme, Petra

“…Structural discovery of guanine nucleotide exchange factor (GEF) protein complexes is likely to become increasingly relevant with the development of new…”
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Cadherins and catenins in cancer: connecting cancer pathways and tumor microenvironment by Lin, Wan-Hsin, Cooper, Lisa M, Anastasiadis, Panos Z

“…Cadherin-catenin complexes are integral components of the adherens junctions crucial for cell-cell adhesion and tissue homeostasis. Dysregulation of these…”
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Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders by Svitkina, Tatyana, Lin, Wan-Hsin, Webb, Donna J, Yasuda, Ryohei, Wayman, Gary A, Van Aelst, Linda, Soderling, Scott H

“…The small size of dendritic spines belies the elaborate role they play in excitatory synaptic transmission and ultimately complex behaviors. The cytoskeletal…”
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A Syx-RhoA-Dia1 signaling axis regulates cell cycle progression, DNA damage, and therapy resistance in glioblastoma by Lin, Wan-Hsin, Feathers, Ryan W, Cooper, Lisa M, Lewis-Tuffin, Laura J, Chen, Jiaxiang, Sarkaria, Jann N, Anastasiadis, Panos Z

“…Glioblastomas (GBM) are aggressive tumors that lack effective treatments. Here, we show that the Rho family guanine nucleotide exchange factor Syx promotes GBM…”
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Standard operating procedure for curation and clinical interpretation of variants in cancer by Danos, Arpad M, Krysiak, Kilannin, Barnell, Erica K, Coffman, Adam C, McMichael, Joshua F, Kiwala, Susanna, Spies, Nicholas C, Sheta, Lana M, Pema, Shahil P, Kujan, Lynzey, Clark, Kaitlin A, Wollam, Amber Z, Rao, Shruti, Ritter, Deborah I, Sonkin, Dmitriy, Raca, Gordana, Lin, Wan-Hsin, Grisdale, Cameron J, Kim, Raymond H, Wagner, Alex H, Madhavan, Subha, Griffith, Malachi, Griffith, Obi L

“…Manually curated variant knowledgebases and their associated knowledge models are serving an increasingly important role in distributing and interpreting…”
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Differed IL-1 Beta Response between Active TB and LTBI Cases by Ex Vivo Stimulation of Human Monocyte-Derived Macrophage with TB-Specific Antigen by Wang, Jann-Yuan, Yan, Bo-Shiun, Chang, Chia-Hao, Chang, Lih-Yu, Lee, Meng-Rui, Lin, Wan-Hsin

“…Background. The difference of macrophage-specific interleukin-1 beta (IL-1b) response between latent tuberculosis infection (LTBI) and active tuberculosis (TB)…”
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The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration by Broussard, Joshua A, Lin, Wan-hsin, Majumdar, Devi, Anderson, Bridget, Eason, Brady, Brown, Claire M, Webb, Donna J

“…Cell migration is a complex process that requires the integration of signaling events that occur in distinct locations within the cell. Adaptor proteins, which…”
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Expression of Polarity Genes in Human Cancer by Lin, Wan-Hsin, Asmann, Yan W., Anastasiadis, Panos Z.

“…Polarity protein complexes are crucial for epithelial apical-basal polarity and directed cell migration. Since alterations of these processes are common in…”
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Syk Tyrosine Kinase Mediates Epstein-Barr Virus Latent Membrane Protein 2A-induced Cell Migration in Epithelial Cells by Lu, Jean, Lin, Wan-Hsin, Chen, Shao-Yin, Longnecker, Richard, Tsai, Shu-Chun, Chen, Chi-Long, Tsai, Ching-Hwa

“…Although spleen tyrosine kinase (Syk) is known to be important in hematopoietic cell development, the roles of Syk in epithelial cells have not been well…”
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Functional roles of VASP phosphorylation in the regulation of chemotaxis and osmotic stress response by Lin, Wan-Hsin, Nelson, Sharon E., Hollingsworth, Ryan J., Chung, Chang Y.

“…Vasodilator‐stimulated phosphoprotein (VASP) plays crucial roles in controlling F‐actin‐driven processes and growing evidence indicates that VASP function is…”
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Cadherin complexes recruit mRNAs and RISC to regulate epithelial cell signaling by Kourtidis, Antonis, Necela, Brian, Lin, Wan-Hsin, Lu, Ruifeng, Feathers, Ryan W, Asmann, Yan W, Thompson, E Aubrey, Anastasiadis, Panos Z

“…Cumulative evidence demonstrates that most RNAs exhibit specific subcellular distribution. However, the mechanisms regulating this phenomenon and its…”
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A compact microfluidic gradient generator using passive pumping by YANDONG GAO, JIASHU SUN, LIN, Wan-Hsin, WEBB, Donna J, DEYU LI

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Standardized evidence-based approach for assessment of oncogenic and clinical significance of NTRK fusions by Saliba, Jason, Church, Alanna J., Rao, Shruti, Danos, Arpad, Furtado, Larissa V., Laetsch, Theodore, Zhang, Liying, Nardi, Valentina, Lin, Wan-Hsin, Ritter, Deborah I., Madhavan, Subha, Li, Marilyn M., Griffith, Obi L., Griffith, Malachi, Raca, Gordana, Roy, Angshumoy

“…•A systematic framework for evidence assessment of pathogenic fusions is needed.•Curation standards for NTRK fusions developed by the clingen somatic cancer…”
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Vasodilator-stimulated Phosphoprotein (VASP) Induces Actin Assembly in Dendritic Spines to Promote Their Development and Potentiate Synaptic Strength by Lin, Wan-Hsin, Nebhan, Caroline A., Anderson, Bridget R., Webb, Donna J.

“…Dendritic spines are small actin-rich structures that receive the majority of excitatory synaptic input in the brain. The actin-based dynamics of spines are…”
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Myosin X and its motorless isoform differentially modulate dendritic spine development by regulating trafficking and retention of vasodilator-stimulated phosphoprotein by Lin, Wan-Hsin, Hurley, Joshua T, Raines, Alexander N, Cheney, Richard E, Webb, Donna J

“…Myosin X (Myo10) is an unconventional myosin with two known isoforms: full-length (FL)-Myo10 that has motor activity, and a recently identified brain-expressed…”
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A community approach to the cancer-variant-interpretation bottleneck by Krysiak, Kilannin, Danos, Arpad M, Kiwala, Susanna, McMichael, Joshua F, Coffman, Adam C, Barnell, Erica K, Sheta, Lana, Saliba, Jason, Grisdale, Cameron J, Kujan, Lynzey, Pema, Shahil, Lever, Jake, Spies, Nicholas C, Chiorean, Andreea, Rieke, Damian T, Clark, Kaitlin A, Jani, Payal, Takahashi, Hideaki, Horak, Peter, Ritter, Deborah I, Zhou, Xin, Ainscough, Benjamin J, Delong, Sean, Lamping, Mario, Marr, Alex R, Li, Brian V, Lin, Wan-Hsin, Terraf, Panieh, Salama, Yasser, Campbell, Katie M, Farncombe, Kirsten M, Ji, Jianling, Zhao, Xiaonan, Xu, Xinjie, Kanagal-Shamanna, Rashmi, Cotto, Kelsy C, Skidmore, Zachary L, Walker, Jason R, Zhang, Jinghui, Milosavljevic, Aleksandar, Patel, Ronak Y, Giles, Rachel H, Kim, Raymond H, Schriml, Lynn M, Mardis, Elaine R, Jones, Steven J M, Raca, Gordana, Rao, Shruti, Madhavan, Subha, Wagner, Alex H, Griffith, Obi L, Griffith, Malachi

“…As guidelines, therapies, and literature on cancer variants expand, the lack of consensus variant interpretations impedes clinical applications. CIViC is a…”
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Actin and Actin-Binding Proteins: Masters of Dendritic Spine Formation, Morphology, and Function by Lin, Wan-Hsin, Webb, Donna J

“…Dendritic spines are actin-rich protrusions that comprise the postsynaptic sites of synapses and receive the majority of excitatory synaptic inputs in the…”
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516 Functional Impact of Intratumoral Heterogeneity in Therapeutic Vulnerabilities Across Enhancing and Non-Enhancing Tumor Components of Glioblastoma: A Paradigm-Shifting Personalized Medicine Approach by Garcia, Diogo P., Lin, Wan-hsin, Brooks, Mieu, Feathers, Ryan, Middlebrooks, Erik, Chaichana, Kaisorn L., Anastasiadis, Panagiotis, Quinones-Hinojosa, Alfredo

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