Search Results - "Lin, Tai An"

Current and emerging therapies for Achondroplasia: The dawn of precision medicine by Dardenne, Etienne, Ishiyama, Noboru, Lin, Tai-An, Lucas, Matthew C

“…[Display omitted] Achondroplasia is a rare disease affecting bone growth and is caused by a missense mutation in the fibroblast growth factor receptor 3…”
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CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression by Guo, Yanxia, Walsh, Alice M, Fearon, Ursula, Smith, Malcolm D, Wechalekar, Mihir D, Yin, Xuefeng, Cole, Suzanne, Orr, Carl, McGarry, Trudy, Canavan, Mary, Kelly, Stephan, Lin, Tai-An, Liu, Xuejun, Proudman, Susanna M, Veale, Douglas J, Pitzalis, Costantino, Nagpal, Sunil

“…The inflammatory CD40-CD40L pathway is implicated in various autoimmune diseases, but the activity status of this pathway in various stages of rheumatoid…”
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Discovery of siRNA Lipid Nanoparticles to Transfect Suspension Leukemia Cells and Provide In Vivo Delivery Capability by He, Wei, Bennett, Michael J, Luistro, Leopoldo, Carvajal, Daisy, Nevins, Thomas, Smith, Melissa, Tyagi, Gaurav, Cai, James, Wei, Xin, Lin, Tai-An, Heimbrook, David C, Packman, Kathryn, Boylan, John F

“…As a powerful research tool, siRNA's therapeutic and target validation utility with leukemia cells and long-term gene knockdown is severely restricted by the…”
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Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors by Ross-Macdonald, Petra, de Silva, Heshani, Guo, Qi, Xiao, Hong, Hung, Chen-Yi, Penhallow, Becky, Markwalder, Jay, He, Liqi, Attar, Ricardo M, Lin, Tai-an, Seitz, Steven, Tilford, Charles, Wardwell-Swanson, Judith, Jackson, Donald

“…In developing inhibitors of the LIM kinases, the initial lead molecules combined potent target inhibition with potent cytotoxic activity. However, as…”
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RG7212 Anti-TWEAK mAb Inhibits Tumor Growth through Inhibition of Tumor Cell Proliferation and Survival Signaling and by Enhancing the Host Antitumor Immune Response by XUEFENG YIN, LUISTRO, Leopoldo, XIAOQIAN WANG, PACKMAN, Kathryn, ROSINSKI, Jim, BERKOFSKY-FESSLER, Windy, TANG, Jian-Ping, PANT, Saumya, GEHO, David, VEGA-HARRING, Suzana, DEMARIO, Mark, LEVITSKY, Hy, HUA ZHONG, SIMCOX, Mary, SMITH, Melissa, NEVINS, Tom, SCHOSTACK, Kathleen, HILTON, Holly, LIN, Tai-An, TRUITT, Theresa, BIONDI, Denise

“…To explore the role of TWEAK in tumor growth and antitumor immune response and the activity and mechanism of RG7212, an antagonistic anti-TWEAK antibody, in…”
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Preclinical Characterization of Linrodostat Mesylate, a Novel, Potent, and Selective Oral Indoleamine 2,3-Dioxygenase 1 Inhibitor by Balog, Aaron, Lin, Tai-An, Maley, Derrick, Gullo-Brown, Johnni, Kandoussi, Enzo Hamza, Zeng, Jianing, Hunt, John T

“…Tumors can exploit the indoleamine 2,3-dioxygenase 1 (IDO1) pathway to create an immunosuppressive microenvironment. Activated IDO1 metabolizes tryptophan into…”
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Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function by Pause, Arnim, Belsham, Graham J, Gingras, Anne-Claude, Donzé, Olivier, Lin, Tai-An, Lawrence, John C, Sonenberg, Nahum

“…The cloning is described of two related human complementary DNAs encoding polypeptides that interact specifically with the translation initiation factor…”
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The Rapamycin-Binding Domain Governs Substrate Selectivity by the Mammalian Target of Rapamycin by McMahon, Lloyd P., Choi, Kin M., Lin, Tai-An, Abraham, Robert T., Lawrence, John C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation by Lin, Tai-An, Kong, Xianming, Timothy A. J. Haystead, Pause, Arnim, Belsham, Graham, Sonenberg, Nahum, Lawrence, John C.

“…PHAS-I is a heat-stable protein (relative molecular mass $\approx$12,400) found in many tissues. It is rapidly phosphorylated in rat adipocytes incubated with…”
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Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1 by Markwalder, Jay A., Balog, Aaron J., Williams, David K., Nara, Susheel J., Reddy, Ratnakar, Roy, Saumya, Kanyaboina, Yadagiri, Li, Xin, Johnston, Kathy, Fan, Yi, Lewis, Hal, Marsilio, Frank, Yan, Chunhong, Critton, David, Newitt, John A., Traeger, Sarah C., Wu, Dauh-Rurng, Jure-Kunkel, Maria N., Jayaraman, Lata, Lin, Tai-An, Sinz, Michael W., Hunt, John T., Seitz, Steven P.

“…[Display omitted] Starting from the dialkylaniline indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor lead 3 (IDO1 HeLa IC50 = 7.0 nM), an iterative process of…”
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Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1 by Cherney, Emily C, Zhang, Liping, Nara, Susheel, Zhu, Xiao, Gullo-Brown, Johnni, Maley, Derrick, Lin, Tai-An, Hunt, John T, Huang, Christine, Yang, Zheng, Darienzo, Celia, Discenza, Lorell, Ranasinghe, Asoka, Grubb, Mary, Ziemba, Theresa, Traeger, Sarah C, Li, Xin, Johnston, Kathy, Kopcho, Lisa, Fereshteh, Mark, Foster, Kimberly, Stefanski, Kevin, Fargnoli, Joseph, Swanson, Jesse, Brown, Jennifer, Delpy, Diane, Seitz, Steven P, Borzilleri, Robert, Vite, Gregory, Balog, Aaron

“…Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing dioxygenase enzyme implicated in cancer immune response. This account details the discovery of…”
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Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy by Zhang, Liping, Cherney, Emily C, Zhu, Xiao, Lin, Tai-an, Gullo-Brown, Johnni, Maley, Derrick, Johnston-Allegretto, Kathy, Kopcho, Lisa, Fereshteh, Mark, Huang, Christine, Li, Xin, Traeger, Sarah C, Dhar, Gopal, Anandam, Aravind, Mahankali, Sandeep, Padmanabhan, Shweta, Rajanna, Prabhakar, Murali, Venkata, Mariappan, Thanga, Borzilleri, Robert, Vite, Gregory, Hunt, John T, Balog, Aaron

“…Indoleamine 2,3-dioxygenase 1 (IDO1) has been identified as a target for small-molecule immunotherapy for the treatment of a variety of cancers including renal…”
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Control of the Translational Regulators PHAS-I and PHAS-II by Insulin and cAMP in 3T3-L1 Adipocytes by Lin, Tai-An, Lawrence, John C.

“…The eukaryotic initiation factor 4E (eIF-4E)-binding proteins PHAS-I and PHAS-II were found to have overlapping but different patterns of expression in…”
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KU812 cells provide a novel in vitro model of the human IL-33/ST2L axis: Functional responses and identification of signaling pathways by Tare, Nadine, Li, Hongli, Morschauser, Andrew, Cote-Sierra, Javier, Ju, Grace, Renzetti, Louis, Lin, Tai-An

“…Activation of interleukin-1 family receptor ST2L by its ligand interleukin-33 (IL-33) is an important component in inflammatory responses. Peripheral blood…”
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Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors by Cherney, Emily C, Zhang, Liping, Guo, Weiwei, Huang, Audris, Williams, David, Seitz, Steven, Shan, Weifang, Zhu, Xiao, Gullo-Brown, Johnni, Maley, Derrick, Lin, Tai-an, Hunt, John T, Huang, Christine, Yang, Zheng, D’Arienzo, Celia J, Discenza, Lorell N, Ranasinghe, Asoka, Grubb, Mary F, Traeger, Sarah C, Li, Xin, Johnston, Kathy A, Kopcho, Lisa, Fereshteh, Mark, Foster, Kimberly A, Stefanski, Kevin, Delpy, Diane, Dhar, Gopal, Anandam, Aravind, Mahankali, Sandeep, Padmanabhan, Shweta, Rajanna, Prabhakar, Murali, Venkata, Mariappan, T. Thanga, Pattasseri, Shabeerali, Nimje, Roshan Y, Hong, Zhenqiu, Kempson, James, Rampulla, Richard, Mathur, Arvind, Gupta, Anuradha, Borzilleri, Robert, Vite, Gregory, Balog, Aaron

“…IDO1 inhibitors have shown promise as immunotherapies for the treatment of a variety of cancers, including metastatic melanoma and renal cell carcinoma. We…”
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The androgen receptor can signal through Wnt/beta-Catenin in prostate cancer cells as an adaptation mechanism to castration levels of androgens by Schweizer, Liang, Rizzo, Cheryl A, Spires, Thomas E, Platero, J Suso, Wu, Qiuyan, Lin, Tai-An, Gottardis, Marco M, Attar, Ricardo M

“…A crucial event in Prostate Cancer progression is the conversion from a hormone-sensitive to a hormone-refractory disease state. Correlating with this…”
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Modulation of cofilin phosphorylation by inhibition of the Lim family kinases by He, Liqi, Seitz, Steven P., Trainor, George L., Tortolani, David, Vaccaro, Wayne, Poss, Michael, Tarby, Christine M., Tokarski, John S., Penhallow, Becky, Hung, Chen-Yi, Attar, Ricardo, Lin, Tai-An

“…The design, synthesis, and SAR for a series of aminothiazole pyrimidines as potent LIMK inhibitors are described. Compound 31 effectively inhibited cofilin…”
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Discovery of a 1H-Benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity by Wittman, Mark, Carboni, Joan, Attar, Ricardo, Balasubramanian, Balu, Balimane, Praveen, Brassil, Patrick, Beaulieu, Francis, Chang, Chiehying, Clarke, Wendy, Dell, Janet, Eummer, Jeffrey, Frennesson, David, Gottardis, Marco, Greer, Ann, Hansel, Steven, Hurlburt, Warren, Jacobson, Bruce, Krishnananthan, Subramaniam, Lee, Francis Y, Li, Aixin, Lin, Tai-An, Liu, Peiying, Ouellet, Carl, Sang, Xiaopeng, Saulnier, Mark G, Stoffan, Karen, Sun, Yax, Velaparthi, Upender, Wong, Henry, Yang, Zheng, Zimmermann, Kurt, Zoeckler, Mary, Vyas, Dolatrai

“…Compound 3 (BMS-536924), a novel small-molecule inhibitor of the insulin-like growth factor receptor kinase with equal potency against the insulin receptor is…”
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Selective Itk Inhibitors Block T-Cell Activation and Murine Lung Inflammation by Lin, Tai-An, McIntyre, Kim W, Das, Jagabandhu, Liu, Chunjian, O'Day, Kathleen D, Penhallow, Becky, Hung, Chen-Yi, Whitney, Gena S, Shuster, David J, Yang, XiaoXia, Townsend, Robert, Postelnek, Jennifer, Spergel, Steven H, Lin, James, Moquin, Robert V, Furch, Joseph A, Kamath, Amrita V, Zhang, Hongjian, Marathe, Punit H, Perez-Villar, Juan J, Doweyko, Arthur, Killar, Loran, Dodd, John H, Barrish, Joel C, Wityak, John, Kanner, Steven B

“…Nonreceptor protein tyrosine kinases including Lck, ZAP-70, and Itk play essential roles in T-cell receptor (TCR) signaling. Gene knockout studies have…”
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Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors by Das, Jagabandhu, Furch, Joseph A., Liu, Chunjian, Moquin, Robert V., Lin, James, Spergel, Steven H., McIntyre, Kim W., Shuster, David J., O’Day, Kathleen D., Penhallow, Becky, Hung, Chen-Yi, Doweyko, Arthur M., Kamath, Amrita, Zhang, Hongjian, Marathe, Punit, Kanner, Steven B., Lin, Tai-An, Dodd, John H., Barrish, Joel C., Wityak, John

“…A series of structurally novel aminothiazole based small molecule inhibitors of Itk were prepared to elucidate their structure–activity relationships (SARs),…”
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