Search Results - "Lin, Shuailiang"

Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively by Zhan, Cheng, Zhou, Jingfeng, Feng, Qiru, Zhang, Ju-En, Lin, Shuailiang, Bao, Junhong, Wu, Ping, Luo, Minmin

“…POMC-derived melanocortins inhibit food intake. In the adult rodent brain, POMC-expressing neurons are located in the arcuate nucleus (ARC) and the nucleus…”
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In Vivo Transcriptional Activation Using CRISPR/Cas9 in Drosophila by Lin, Shuailiang, Ewen-Campen, Ben, Ni, Xiaochun, Housden, Benjamin E, Perrimon, Norbert

“…A number of approaches for Cas9-mediated transcriptional activation have recently been developed, allowing target genes to be overexpressed from their…”
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Highly efficient Cas9-mediated transcriptional programming by Chavez, Alejandro, Scheiman, Jonathan, Vora, Suhani, Pruitt, Benjamin W, Tuttle, Marcelle, P R Iyer, Eswar, Lin, Shuailiang, Kiani, Samira, Guzman, Christopher D, Wiegand, Daniel J, Ter-Ovanesyan, Dmitry, Braff, Jonathan L, Davidsohn, Noah, Housden, Benjamin E, Perrimon, Norbert, Weiss, Ron, Aach, John, Collins, James J, Church, George M

“…The fusion of three transcriptional activation domains to a nuclease-deficient Cas9 achieves robust induction of gene expression and can induce differentiation…”
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Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9 by Ren, Xingjie, Sun, Jin, Housden, Benjamin E., Hu, Yanhui, Roesel, Charles, Lin, Shuailiang, Liu, Lu-Ping, Yang, Zhihao, Mao, Decai, Sun, Lingzhu, Wu, Qujie, Jie, Jun-Yuan, Xi, Jianzhong, Mohr, Stephanie E., Xu, Jiang, Perrimon, Norbert, Ni, Jian-Quan

“…The ability to engineer genomes in a specific, systematic, and cost-effective way is critical for functional genomic studies. Recent advances using the…”
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Multiplex Genome Engineering Using CRISPR/Cas Systems by Cong, Le, Ran, F. Ann, Cox, David, Lin, Shuailiang, Barretto, Robert, Habib, Naomi, Hsu, Patrick D., Wu, Xuebing, Jiang, Wenyan, Marraffini, Luciano A., Zhang, Feng

“…Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II prokaryotic CRISPR (clustered…”
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Cas9-based genome editing in Drosophila by Housden, Benjamin E, Lin, Shuailiang, Perrimon, Norbert

“…Our ability to modify the Drosophila genome has recently been revolutionized by the development of the CRISPR system. The simplicity and high efficiency of…”
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Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi by Housden, Benjamin E, Valvezan, Alexander J, Kelley, Colleen, Sopko, Richelle, Hu, Yanhui, Roesel, Charles, Lin, Shuailiang, Buckner, Michael, Tao, Rong, Yilmazel, Bahar, Mohr, Stephanie E, Manning, Brendan D, Perrimon, Norbert

“…The tuberous sclerosis complex (TSC) family of tumor suppressors, TSC1 and TSC2, function together in an evolutionarily conserved protein complex that is a…”
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