Prolactin-releasing peptide (PrRP) promotes awakening and suppresses absence seizures

Prolactin releasing peptide (PrRP) is a recently identified neuropeptide that stimulates prolactin release from pituitary cells. The presence of its receptor outside the hypothalamic-pituitary axis suggests that it may have other functions. We present here evidence that PrRP can modulate the activit...

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Bibliographic Details
Published in:	Neuroscience Vol. 114; no. 1; pp. 229 - 238
Main Authors:	Lin, S.H.S, Arai, A.C, España, R.A, Berridge, C.W, Leslie, F.M, Huguenard, J.R, Vergnes, M, Civelli, O
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 01-01-2002 Elsevier
Subjects:	Action Potentials - drug effects Action Potentials - physiology Animals Biological and medical sciences Biological Clocks - drug effects Biological Clocks - physiology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Electroencephalography - drug effects Epilepsy, Absence - drug therapy Epilepsy, Absence - metabolism Epilepsy, Absence - physiopathology Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - biosynthesis Glutamate Decarboxylase - genetics Glutamate Decarboxylase - metabolism GPCR Hypothalamic Hormones - metabolism Hypothalamic Hormones - pharmacology Intralaminar Thalamic Nuclei - drug effects Intralaminar Thalamic Nuclei - metabolism Intralaminar Thalamic Nuclei - physiopathology Isoenzymes - genetics Isoenzymes - metabolism Male Neurons - drug effects Neurons - metabolism Neuropeptides - metabolism Neuropeptides - pharmacology Organ Culture Techniques petit-mal seizures prolactin releasing peptide Prolactin-Releasing Hormone Rats Rats, Mutant Strains Rats, Sprague-Dawley Receptors, Neuropeptide - drug effects Receptors, Neuropeptide - genetics Receptors, Neuropeptide - metabolism reticular nucleus of the thalamus RNA, Messenger - metabolism sleep Sleep - drug effects Sleep - physiology Sleep Wake Disorders - drug therapy Sleep Wake Disorders - metabolism Sleep Wake Disorders - physiopathology thalamic slice Vertebrates: nervous system and sense organs Wakefulness - drug effects Wakefulness - physiology PrRP, prolactin releasing peptide EMG, electromyograph EDTA, ethylenediaminetetra-acetate EEG, electroencephalogram RTN, reticular thalamic nucleus sleep reticular nucleus of the thalamus GAERS, genetic absence epilepsy rats from Strasbourg thalamic slice aCSF, artificial cerebrospinal fluid GAD, glutamate decarboxylase GPCR petit-mal seizures ECoG, cortical EEG prolactin releasing peptide SWD, spike wave discharges HSD, honestly significant difference Nervous system diseases Rat Prolactin releasing hormone Epilepsy Rodentia Central nervous system Reticular nucleus Sleep disorder Petit mal Neuropeptide Cerebral disorder Vertebrata Mammalia Treatment Animal Central nervous system disease Awakening Thalamus Brain (vertebrata)
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Summary:	Prolactin releasing peptide (PrRP) is a recently identified neuropeptide that stimulates prolactin release from pituitary cells. The presence of its receptor outside the hypothalamic-pituitary axis suggests that it may have other functions. We present here evidence that PrRP can modulate the activity of the reticular thalamic nucleus, a brain region with prominent PrRP receptor expression that is critical for sleep regulation and the formation of non-convulsive absence seizures. Intracerebroventricular injection of PrRP (1–10 nmol) into sleeping animals significantly suppresses sleep oscillations and promotes rapid and prolonged awakening. Higher concentrations of PrRP (10–100 nmol) similarly suppress spike wave discharges seen during absence seizures in genetic absence epilepsy rats from Strasbourg, an animal model for this disorder. In concordance with these findings, PrRP suppressed evoked oscillatory burst activity in reticular thalamic slices in vitro. These results indicate that PrRP modulates reticular thalamic function and that activation of its receptor provides a new target for therapies directed at sleep disorders and absence seizures.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0306-4522 1873-7544
DOI:	10.1016/S0306-4522(02)00248-8