Search Results - "Lin, Qian‐Meng"

Functional characterization of 27 CYP3A4 variants on macitentan metabolism in vitro by Li, Ying‐hui, Lu, Xiang‐ran, Lin, Qian‐meng, Huang, Huan‐le, Liang, Xiao‐long, Cai, Jian‐ping, Cui, Ju, Hu, Guo‐xin

“…Objective Macitentan is a new choice for pulmonary hypertension treatment which is converted to active metabolite ACT132577 by human cytochrome P450 3A4. Human…”
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Effects of 27 CYP3A4 protein variants on saxagliptin metabolism in vitro by liu, Qian, Ou‐Yang, Qiu‐Geng, Lin, Qian‐Meng, Lu, Xiang‐Ran, Ma, Ya‐Qing, Li, Ying‐Hui, Xu, Ren‐Ai, Lin, Dong‐dong, Hu, Guo‐Xin, Cai, Jian‐Ping

“…Saxagliptin is a dipeptidyl peptidase 4 (DPP‐4) inhibitor widely used in patients with type 2 diabetes. It can increase the amount of insulin after meals and…”
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Characterization of Genetic Variation in CYP3A4 on the Metabolism of Cabozantinib in Vitro by Lin, Qian-meng, Li, Ying-hui, Lu, Xiang-ran, Wang, Ru, Pang, Ni-hong, Xu, Ren-ai, Cai, Jian-ping, Hu, Guo-xin

“…Cabozantinib is a multityrosine kinase inhibitor and has a wide range of applications in the clinic, whose metabolism is predominately dependent on CYP3A4…”
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Functional characterization of 27 CYP3A4 protein variants to metabolize regorafenib in vitro by Li, Ying‐Hui, Lin, Qian‐Meng, Pang, Ni‐Hong, Zhang, Xiao‐Dan, Huang, Huan‐Le, Cai, Jian-Ping, Hu, Guo-Xin

“…Aim Regorafenib is a tyrosine kinase inhibitor that is mainly metabolized by CYP3A4. The genetic polymorphism of CYP3A4 would contribute to differences in…”
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Evaluation of the Effects of Apatinib on the Pharmacokinetics of Venlafaxine and O‐desmethylvenlafaxine in SD Male Rats by UPLC–MS/MS by Bao, Su‐su, Wen, Jian, Lin, Qian‐meng, Li, Ying‐hui, Huang, Yang‐ge, Zhou, Hong‐yu, Hu, Guo‐xin

“…The objective of this study was to evaluate the effect of apatinib on the pharmacokinetics of venlafaxine and O‐desmethylvenlafaxine in SD rats and the…”
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Functional characteristics of CYP3A4 allelic variants on the metabolism of loperamide in vitro by Lin, Qian-Meng, Li, Ying-Hui, Liu, Qian, Pang, Ni-Hong, Xu, Ren-Ai, Cai, Jian-Ping, Hu, Guo-Xin

“…Cytochrome P450 3A4 (CYP3A4) appears to be genetically polymorphic, which in turn contributes to interindividual variability in response to therapeutic drugs…”
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Clinical and Second-look Arthroscopic Results for Derotational Distal Femoral Osteotomy With Medial Patellofemoral Ligament Reconstruction for Recurrent Patellar Dislocation With Increased Femoral Anteversion: A Series of 102 Cases With a Minimum Clinical Follow-up of 2 Years by Zhang, Zhi-Jun, Di, Meng Lin Qian, Song, Guan-Yang, Li, Yue, Cao, Yan-Wei, Zheng, Tong, Feng, Hua, Zhang, Hui

“…Background: Derotational distal femoral osteotomy (DDFO) has been used to treat patients with recurrent patellar dislocation (RPD) with increased femoral…”
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Inhibitory Mechanisms of Myricetin on Human and Rat Liver Cytochrome P450 Enzymes by Lou, Dan, Bao, Su-su, Li, Ying-hui, Lin, Qian-meng, Yang, Su-fen, He, Jia-yang

“…Background and Objectives Myricetin is a flavonoid compound that is abundant in teas, red wine, berries, herbs and vegetables with a variety of pharmacological…”
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Investigation of the effects of axitinib on the pharmacokinetics of loperamide and its main metabolite N-demethylated loperamide in rats by UPLC-MS/MS by Lin, Qian-meng, Pang, Ni-hong, Li, Ying-hui, Huang, Huan-le, Zhang, Xiao-dan, Hu, Guo-xin, Wang, Zeng-shou

“…The epidemic of loperamide abuse and misuse in the patients for the alternative to opioids has become an increasing worldwide concern and has led to…”
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Investigation of the Inhibitory Effect of Simvastatin on the Metabolism of Lidocaine Both in vitro and in vivo by Wang, Ying, Ou-Yang, Qiu-Geng, Huang, Wan-Li, Huang, Huan-le, Zhuang, Xin-Lei, Lin, Qian-Meng, Zeng, Da-Li

“…Lidocaine has cardiovascular and neurologic toxicity, which is dose-dependent. Due to CYP3A4-involved metabolism, lidocaine may be prone to drug-drug…”
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Functional characteristics of CYP3A4 allelic variants on the metabolism of loperamide in vitro This article was published in the following Dove Press journal: Infection and Drug Resistance by Lin, Qian-Meng, Li, Ying-Hui, Liu, Qian, Pang, Ni-Hong, Xu, Ren-Ai, Cai, Jian-Ping, Hu, Guo-Xin

“…Background: Cytochrome P450 3A4 (CYP3A4) appears to be genetically polymorphic, which in turn contributes to interindividual variability in response to…”
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A simple method for solving unidirectional methane gas flow in coal seam based on similarity solution by Zhou, Yan, Meng, Qian, Lin, Baiquan, Qin, Jilong, Zhou, Guiping

“…The equation used to model the unidirectional flow of methane gas in coal seams is usually formulated as a nonlinear partial differential equation,which needs…”
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New Research Progress of the Novel Target Drugs for the Treatment of Type 2 Diabetes Mellitus by Pengxiang ZHANG, Lin ZENG, Lu MENG, Qian HUANG, Gaoxiang WANG, Deliang LIU

“…At present, there are many types of drugs for clinical treatment of type 2 diabetes mellitus (T2DM) , there are differences in the hypoglycemic mechanisms and…”
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