Search Results - "Lin, Peicong"
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Model building of protein complexes from intermediate-resolution cryo-EM maps with deep learning-guided automatic assembly
Published in Nature communications (13-07-2022)“…Advances in microscopy instruments and image processing algorithms have led to an increasing number of cryo-electron microscopy (cryo-EM) maps. However,…”
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Deep transfer learning for inter-chain contact predictions of transmembrane protein complexes
Published in Nature communications (15-08-2023)“…Membrane proteins are encoded by approximately a quarter of human genes. Inter-chain residue-residue contact information is important for structure prediction…”
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Efficient 3D conformer generation of cyclic peptides formed by a disulfide bond
Published in Journal of cheminformatics (03-05-2022)“…Cyclic peptides formed by disulfide bonds have been one large group of common drug candidates in drug development. Structural information of a peptide is…”
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Deep learning in modeling protein complex structures: From contact prediction to end-to-end approaches
Published in Current opinion in structural biology (01-04-2024)“…Protein–protein interactions play crucial roles in many biological processes. Traditionally, protein complex structures are normally built by protein–protein…”
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TRScore: a 3D RepVGG-based scoring method for ranking protein docking models
Published in Bioinformatics (Oxford, England) (28-04-2022)“…Abstract Motivation Protein–protein interactions (PPI) play important roles in cellular activities. Due to the technical difficulty and high cost of…”
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Docking cyclic peptides formed by a disulfide bond through a hierarchical strategy
Published in Bioinformatics (02-09-2022)“…Abstract Motivation Cyclization is a common strategy to enhance the therapeutic potential of peptides. Many cyclic peptide drugs have been approved for…”
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DeepHomo2.0: improved protein–protein contact prediction of homodimers by transformer-enhanced deep learning
Published in Briefings in bioinformatics (19-01-2023)“…Abstract Protein–protein interactions play an important role in many biological processes. However, although structure prediction for monomer proteins has…”
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Prediction of protein assemblies, the next frontier: The CASP14‐CAPRI experiment
Published in Proteins, structure, function, and bioinformatics (01-12-2021)“…We present the results for CAPRI Round 50, the fourth joint CASP‐CAPRI protein assembly prediction challenge. The Round comprised a total of twelve targets,…”
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Challenges and opportunities of automated protein‐protein docking: HDOCK server vs human predictions in CAPRI Rounds 38‐46
Published in Proteins, structure, function, and bioinformatics (01-08-2020)“…Protein‐protein docking plays an important role in the computational prediction of the complex structure between two proteins. For years, a variety of docking…”
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Protein–protein contact prediction by geometric triangle-aware protein language models
Published in Nature machine intelligence (01-11-2023)“…Information regarding the residue–residue distance between interacting proteins is important for modelling the structures of protein complexes, as well as…”
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TRScore: a three-dimensional RepVGG-based scoring method for ranking protein docking models
Published in Bioinformatics (Oxford, England) (23-02-2022)“…Protein-protein interactions (PPI) play important roles in cellular activities. Due to the technical difficulty and high cost of experimental methods, there…”
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