Search Results - "Lin, Nancy L."

AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl by Broudy, Virginia C, Lin, Nancy L

“…Thrombopoietin (TPO) plays a pivotal role in megakaryopoiesis. TPO initiates its biological effects by binding to its receptor Mpl. A recombinant protein…”
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Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF β-receptor null mice by Kaminski, Wolfgang E., Lindahl, Per, Lin, Nancy L., Broudy, Virginia C., Crosby, Jeffrey R., Hellström, Mats, Swolin, Birgitta, Bowen-Pope, Daniel F., Martin, Paul J., Ross, Russell, Betsholtz, Christer, Raines, Elaine W.

“…Platelet-derived growth factor (PDGF)-B and PDGF β-receptor (PDGFRβ) deficiency in mice is embryonic lethal and results in cardiovascular, renal, placental,…”
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Lineage-specific growth factors can compensate for stem and progenitor cell deficiencies at the postprogenitor cell level: an analysis of doubly TPO- and G-CSF receptor–deficient mice by Kaushansky, Kenneth, Fox, Norma, Lin, Nancy L., Liles, W. Conrad

“…Multiple lines of evidence indicate that thrombopoietin (TPO) substantially impacts the number of hematopoietic stem cells and progenitors of all myeloid…”
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Membrane localization is not required for Mpl function in normal hematopoietic cells by Otto, Kevin G., Broudy, Virginia C., Lin, Nancy L., Parganas, Evan, Luthi, Jennifer N., Drachman, Jonathan G., Ihle, James N., Blau, C. Anthony

“…Cellular trafficking of growth factor receptors, including cross-talk among receptors at the cell surface, may be important for signal transduction in normal…”
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Analysis of c-kit Receptor Dimerization by Fluorescence Resonance Energy Transfer by Broudy, Virginia C., Lin, Nancy L., Bühring, Hans-Jörg, Komatsu, Norio, Kavanagh, Terrance J.

“…Stem cell factor (SCF) binding to the c-kit receptor triggers homodimerization and intermolecular tyrosine phosphorylation of the c-kit receptor, thus…”
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Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro by BROUDY, V. C, LIN, N. L, KAUSHANSKY, K

“…Thrombopoietin (Tpo), the ligand for the c-mpl receptor, is a major regulator of platelet production in vivo. Treatment of mice with purified recombinant Tpo…”
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Human platelets display high-affinity receptors for thrombopoietin by BROUDY, V. C, LIN, N. L, SABATH, D. F, PAPAYANNOPOULOU, T, KAUSHANSKY, K

“…Thrombopoietin (Tpo) is a major regulator of megakaryopoiesis both in vivo and in vitro. Tpo initiates its biologic effects by binding to the Mpl receptor,…”
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Interaction of stem cell factor and its receptor c-kit mediates lodgment and acute expansion of hematopoietic cells in the murine spleen by Broudy, VC, Lin, NL, Priestley, GV, Nocka, K, Wolf, NS

“…The phenotypes of mice that harbor a defect in the genes encoding either stem cell factor (SCF) or its receptor, c-kit, indicate that this ligand/receptor pair…”
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FLT3 Receptor Expression on the Surface of Normal and Malignant Human Hematopoietic Cells by Turner, Anne M., Lin, Nancy L., Issarachai, Surasit, Lyman, Stewart D., Broudy, Virginia C.

“…FLT3 ligand is a hematopoietic growth factor that plays a key role in growth of primitive hematopoietic cells. FLT3 receptor mRNA is found in early…”
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Signaling via Src family kinases is required for normal internalization of the receptor c-Kit by BROUDY, V. C, LIN, N. L, LILES, W. C, COREY, S. J, O'LAUGHLIN, B, MOU, S, LINNEKIN, D

“…Stem cell factor (SCF) exerts its biological effects by binding to a specific receptor, the tyrosine kinase c-Kit, which is expressed on the cell surface…”
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Soluble c-kit receptor blocks stem cell factor bioactivity in vitro by Dahlen, Debra D., Lin, Nancy L., Liu, Yun-Cai, Broudy, Virginia C.

“…Stem cell factor (SCF) is a growth factor that promotes the survival, proliferation, and differentiation of hematopoietic cells. SCF and its receptor, Kit, are…”
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THE FIFTH IMMUNOGLOBULIN-LIKE DOMAIN OF THE KIT RECEPTOR IS REQUIRED FOR PROTEOLYTIC CLEAVAGE FROM THE CELL SURFACE by Broudy, Virginia C., Lin, Nancy L., Sabath, Diana F.

“…Stem cell factor (SCF) initiates its biological effects by binding to its receptor Kit. Cell surface Kit is proteolytically cleaved to generate soluble Kit…”
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Soluble Kit receptor blocks stem cell factor bioactivity in vitro by DAHLEN, Debra D, LIN, Nancy L, LIU, Yun-Cai, BROUDY, Virginia C

“…Stem cell factor (SCF) is a growth factor that promotes the survival, proliferation, and differentiation of hematopoietic cells. SCF and its receptor, Kit, are…”
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Analysis of c-kit Receptor Dimerization by Fluorescence Resonance Energy Transfer by Broudy, Virginia C., Lin, Nancy L., Bühring, Hans-Jörg, Komatsu, Norio, Kavanagh, Terrance J.

“…Stem cell factor (SCF) binding to the c-kit receptor triggers homodimerization and intermolecular tyrosine phosphorylation of the c-kit receptor, thus…”
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Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit by BROUDY, V. C, LIN, N. L, FOX, N, TAGA, T, SAITO, M, KAUSHANSKY, K

“…Thrombopoietin (Tpo), the ligand for the c-Mpl receptor, is a major regulator of megakaryopoiesis. Treatment of mice with Tpo raises the platelet count…”
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Identification and Characterization of a Soluble c-kit Receptor Produced by Human Hematopoietic Cell Lines by Turner, Anne M., Bennett, Larry G., Lin, Nancy L., Wypych, Jette, Bartley, Timothy D., Hunt, Robert W., Atkins, Harold L., Langley, Keith E., Parker, Vann, Martin, Frank, Broudy, Virginia C.

“…Stem cell factor (SCF) triggers cell growth by binding to cell surface c-kit receptors. Soluble forms of several cytokine receptors have been described and may…”
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Thrombopoietin (c-mpl Ligand) Acts Synergistically With Erythropoietin,Stem Cell Factor, and Interleukin-11 to Enhance Murine MegakaryocyteColony Growth and Increases Megakaryocyte Ploidy In Vitro by Broudy, Virginia C., Lin, Nancy L., Kaushansky, Kenneth

“…Thrombopoietin (Tpo), the ligand for the c-mpl receptor, is a major regulator of platelet production in vivo. Treatment of mice with purified recombinant Tpo…”
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Thrombopoietin Stimulates Colony-Forming Unit-Megakaryocyte Proliferation and Megakaryocyte Maturation Independently of Cytokines That Signal Through the gpl30 Receptor Subunit by Broudy, Virginia C., Lin, Nancy L., Fox, Norma, Taga, Tetsuya, Saito, Mikiyoshi, Kaushansky, Kenneth

“…Thrombopoietin (Tpo), the ligand for the c-MpI receptor, is a major regulator of megakaryopoiesis. Treatment of mice with Tpo raises the platelet count…”
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Structure-function relationships of interleukin-3 : an analysis based on the function and binding characteristics of a series of interspecies chimera of gibbon and murine interleukin-3 by KAUSHANSKY, K, SHOEMAKER, S. G, ABRAMS, J. S, BROUDY, V. C, LIN, N. L, MATOUS, J. V, ALDERMAN, E. M, AGHAJANIAN, J. D, SZKLUT, P. J, VANDYKE, R. E, PEARCE, M. K

“…IL-3 is a glycoprotein cytokine involved in the hematopoietic response to infectious, immunologic, and inflammatory stimuli. In addition, clinical…”
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