Search Results - "Lin, Mike T"

Infection promotes Ser‐214 phosphorylation important for generation of cytotoxic tau variants by Balczon, Ron, Choi, Chung‐Sik, deWeever, Althea, Zhou, Chun, Gwin, Meredith S., Kolb, Claire, Francis, C. Michael, Lin, Mike T., Stevens, Troy

“…Patients who recover from hospital‐acquired pneumonia exhibit a high incidence of end‐organ dysfunction following hospital discharge, including cognitive…”
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GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior by Xu, Yuanyuan, Lin, Mike T, Zha, Xiang-Ming

“…Increased neural activities reduced pH at the synaptic cleft and interstitial spaces. Recent studies have shown that protons function as a neurotransmitter…”
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Tau and Aβ42 in lavage fluid of pneumonia patients are associated with end-organ dysfunction: A prospective exploratory study by Renema, Phoibe, Pittet, Jean-Francois, Brandon, Angela P, Leal, Jr, Sixto M, Gu, Steven, Promer, Grace, Hackney, Andrew, Braswell, Phillip, Pickering, Andrew, Rafield, Grace, Voth, Sarah, Balczon, Ron, Lin, Mike T, Morrow, K Adam, Bell, Jessica, Audia, Jonathon P, Alvarez, Diego, Stevens, Troy, Wagener, Brant M

“…Bacterial pneumonia and sepsis are both common causes of end-organ dysfunction, especially in immunocompromised and critically ill patients. Pre-clinical data…”
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Infection‐induced endothelial amyloids impair memory by Balczon, Ron, Pittet, Jean‐Francois, Wagener, Brant M., Moser, Stephen A., Voth, Sarah, Vorhees, Charles V., Williams, Michael T., Bridges, James P., Alvarez, Diego F., Koloteva, Anna, Xu, Yuanyuan, Zha, Xiang‐Ming, Audia, Jonathon P., Stevens, Troy, Lin, Mike T.

“…ABSTRACTPatients with nosocomial pneumonia exhibit elevated levels of neurotoxic amyloid and tau proteins in the cerebrospinal fluid (CSF). In vitro studies…”
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Correction to: GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior by Xu, Yuanyuan, Lin, Mike T, Zha, Xiang-Ming

“…An amendment to this paper has been published and can be accessed via the original article…”
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Endothelial SK3 channel-associated Ca2+ microdomains modulate blood pressure by Yap, Fui C, Weber, David S, Taylor, Mark S, Townsley, Mary I, Comer, Brian S, Maylie, James, Adelman, John P, Lin, Mike T

“…Activation of vascular endothelial small- (KCa2.3, SK3) or intermediate- (KCa3.1, IK1) conductance Ca(2+)-activated potassium channels induces vasorelaxation…”
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Ablation of Endothelial TRPV4 Channels Alters the Dynamic Ca2+ Signaling Profile in Mouse Carotid Arteries by McFarland, Stuart J., Weber, David S., Choi, Chung-sik, Lin, Mike T., Taylor, Mark S.

“…Transient receptor potential vanilloid 4 channels (TRPV4) are pivotal regulators of vascular homeostasis. Altered TRPV4 signaling has recently been implicated…”
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Ovariectomy-induced reductions in endothelial SK3 channel activity and endothelium-dependent vasorelaxation in murine mesenteric arteries by Yap, Fui C, Taylor, Mark S, Lin, Mike T

“…Mesenteric artery endothelium expresses both small (SK3)- and intermediate (IK1)-conductance Ca(2+)-activated K(+) (KCa) channels whose activity modulates…”
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The SK2-long isoform directs synaptic localization and function of SK2-containing channels by Maylie, James, Adelman, John P, Allen, Duane, Bond, Chris T, Luján, Rafael, Ballesteros-Merino, Carmen, Lin, Mike T, Wang, Kang, Klett, Nathan, Watanabe, Masahiko, Shigemoto, Ryuichi, Stackman Jr, Robert W

“…SK2-containing channels are expressed on dendritic spines of mouse CA1 pyramidal neurons and influence synaptic responses, plasticity and learning. Allen et al…”
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Coupled activity-dependent trafficking of synaptic SK2 channels and AMPA receptors by Lin, Mike T, Luján, Rafael, Watanabe, Masahiko, Frerking, Matthew, Maylie, James, Adelman, John P

“…Small conductance Ca(2+)-activated K(+) type 2 (SK2) channels are expressed in the postsynaptic density of CA1 neurons where they are activated by synaptically…”
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Distinct Ca2+ sources in dendritic spines of hippocampal CA1 neurons couple to SK and Kv4 channels by Wang, Kang, Lin, Mike T, Adelman, John P, Maylie, James

“…Small conductance Ca(2+)-activated K(+) (SK) channels and voltage-gated A-type Kv4 channels shape dendritic excitatory postsynaptic potentials (EPSPs) in…”
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Lung endothelium, tau, and amyloids in health and disease by Balczon, Ron, Lin, Mike T, Voth, Sarah, Nelson, Amy R, Schupp, Jonas C, Wagener, Brant M, Pittet, Jean-Francois, Stevens, Troy

“…Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and function. Lung capillaries in particular represent a unique vascular…”
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SK2 channel plasticity contributes to LTP at Schaffer collateral-CA1 synapses by Luján, Rafael, Lin, Mike T, Adelman, John P, Maylie, James, Watanabe, Masahiko

“…Long-term potentiation (LTP) of synaptic strength at Schaffer collateral synapses has largely been attributed to changes in the number and biophysical…”
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Pneumonia-induced endothelial amyloids reduce dendritic spine density in brain neurons by Scott, Allison M., Jager, Alexandrea C., Gwin, Meredith, Voth, Sarah, Balczon, Ron, Stevens, Troy, Lin, Mike T.

“…Pseudomonas aeruginosa pneumonia elicits endothelial cell release of cytotoxic amyloids that can be recovered from the bronchoalveolar lavage and cerebrospinal…”
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Pneumonia initiates a tauopathy by Balczon, Ron, Lin, Mike T., Lee, Ji Young, Abbasi, Adeel, Renema, Phoibe, Voth, Sarah B., Zhou, Chun, Koloteva, Anna, Michael Francis, C., Sodha, Neel R., Pittet, Jean‐Francois, Wagener, Brant M., Bell, Jessica, Choi, Chung‐Sik, Ventetuolo, Corey E., Stevens, Troy

“…Pneumonia causes short‐ and long‐term cognitive dysfunction in a high proportion of patients, although the mechanism(s) responsible for this effect are…”
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Cytotoxic tau released from lung microvascular endothelial cells upon infection with Pseudomonas aeruginosa promotes neuronal tauopathy by Choi, Chung-Sik, Gwin, Meredith, Voth, Sarah, Kolb, Claire, Zhou, Chun, Nelson, Amy R., deWeever, Althea, Koloteva, Anna, Annamdevula, Naga S., Murphy, James M., Wagener, Brant M., Pittet, Jean-Francois, Lim, Ssang-Taek S., Balczon, Ron, Stevens, Troy, Lin, Mike T.

“…Patients who recover from nosocomial pneumonia oftentimes exhibit long-lasting cognitive impairment comparable with what is observed in Alzheimer’s disease…”
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Nosocomial Pneumonia Elicits an Endothelial Proteinopathy: Evidence for a Source of Neurotoxic Amyloids in Critically Ill Patients by Lin, Mike T, Balczon, Ron, Pittet, Jean-Francois, Wagener, Brant M, Moser, Stephen A, Morrow, K Adam, Voth, Sarah, Francis, C Michael, Leavesley, Silas, Bell, Jessica, Alvarez, Diego F, Stevens, Troy

“…Accumulation of oligomeric t and Aß within the brain contributes to various forms of neuronal dysfunction, leading to learning and memory deficits (4). Because…”
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Human ASIC1a mediates stronger acid-induced responses as compared with mouse ASIC1a by Xu, Yuanyuan, Jiang, Yu-Qing, Li, Ce, He, Mindi, Rusyniak, W George, Annamdevula, Naga, Ochoa, Juan, Leavesley, Silas J, Xu, Jiangping, Rich, Thomas C, Lin, Mike T, Zha, Xiang-Ming

“…Acid-sensing ion channels (ASICs) are the major proton receptor in the brain and a key mediator of acidosis-induced neuronal injuries in disease. Most of…”
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Amyloid‐Beta Precursor Protein: Essential to Lung Capillary Barrier Defense During Acute Infection by Voth, Sarah B., Choi, Chung‐Sik, Morrow, K. A., Gwin, Meredith S., Knighten, Jennifer, Francis, C. M., Lin, Mike T., Gautam, Samir, Frank, Dara W., Audia, Jonathan P., Stevens, Troy, Sharma, Lokesh, Cruz, Charles D.

“…Rationale Pneumonia is a leading cause of acute respiratory distress syndrome (ARDS) and sepsis. Despite resolution of active infection, pro‐inflammatory…”
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Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia by Gwin, Meredith S, Alexeyev, Mikhail F, Geurts, Aron M, Lee, Ji Young, Zhou, Chun, Yang, Xi-Ming, Cohen, Michael V, Downey, James M, Barrington, Robert A, Spadafora, Domenico, Audia, Jonathon P, Frank, Dara W, Voth, Sarah, Pastukh, Viktoriya V, Bell, Jessica, Ayers, Linn, Tambe, Dhananjay T, Nelson, Amy R, Balczon, Ron, Lin, Mike T, Stevens, Troy

“…Pneumonia elicits the production of cytotoxic beta amyloid (Aβ) that contributes to end-organ dysfunction, yet the mechanism(s) linking infection to activation…”
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