Search Results - "Lin, Leon"

Viromimetic STING Agonist‐Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus by Lin, Leon Chien‐Wei, Huang, Chen‐Yu, Yao, Bing‐Yu, Lin, Jung‐Chen, Agrawal, Anurodh, Algaissi, Abdullah, Peng, Bi‐Hung, Liu, Yu‐Han, Huang, Ping‐Han, Juang, Rong‐Huay, Chang, Yuan‐Chih, Tseng, Chien‐Te, Chen, Hui‐Wen, Hu, Che‐Ming Jack

“…The continued threat of emerging, highly lethal infectious pathogens such as Middle East respiratory syndrome coronavirus (MERS‐CoV) calls for the development…”
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Kinetics of antigen expression and epitope presentation during virus infection by Croft, Nathan P, Smith, Stewart A, Wong, Yik Chun, Tan, Chor Teck, Dudek, Nadine L, Flesch, Inge E A, Lin, Leon C W, Tscharke, David C, Purcell, Anthony W

“…Current knowledge about the dynamics of antigen presentation to T cells during viral infection is very poor despite being of fundamental importance to our…”
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Boosting BCG with recombinant influenza A virus tuberculosis vaccines increases pulmonary T cell responses but not protection against Mycobacterium tuberculosis infection by Muflihah, Heni, Flórido, Manuela, Lin, Leon C W, Xia, Yingju, Triccas, James A, Stambas, John, Britton, Warwick J

“…The current Mycobacterium bovis BCG vaccine provides inconsistent protection against pulmonary infection with Mycobacterium tuberculosis. Immunity induced by…”
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Advances and Opportunities in Nanoparticle‐ and Nanomaterial‐Based Vaccines against Bacterial Infections by Lin, Leon Chien‐Wei, Chattopadhyay, Saborni, Lin, Jung‐Chen, Hu, Che‐Ming Jack

“…As the dawn of the postantibiotic era we approach, antibacterial vaccines are becoming increasingly important for managing bacterial infection and reducing the…”
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PLGA particulate subunit tuberculosis vaccines promote humoral and Th17 responses but do not enhance control of Mycobacterium tuberculosis infection by Ashhurst, Anneliese S, Parumasivam, Thaigarajan, Chan, John Gar Yan, Lin, Leon C W, Flórido, Manuela, West, Nicholas P, Chan, Hak-Kim, Britton, Warwick J

“…Tuberculosis places a staggering burden on human health globally. The new World Health Organisation End-TB Strategy has highlighted the urgent need for more…”
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Direct Priming of CD8 + T Cells Persists in the Face of Cowpox Virus Inhibitors of Antigen Presentation by Lin, Leon C W, Croft, Sarah N, Croft, Nathan P, Wong, Yik Chun, Smith, Stewart A, Tang, Swee-Seong, Purcell, Anthony W, Tscharke, David C

“…Vaccinia virus (VACV) was the vaccine used to eradicate smallpox and is being repurposed as a vaccine vector. CD8 T cells are key anti-viral mediators, but…”
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Modified Vaccinia Virus Ankara Can Induce Optimal CD8 + T Cell Responses to Directly Primed Antigens Depending on Vaccine Design by Wong, Yik Chun, Croft, Sarah, Smith, Stewart A, Lin, Leon C W, Cukalac, Tania, La Gruta, Nicole L, Drexler, Ingo, Tscharke, David C

“…A variety of strains of vaccinia virus (VACV) have been used as recombinant vaccine vectors with the aim of inducing robust CD8 T cell immunity. While much of…”
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Pulmonary immunization with a recombinant influenza A virus vaccine induces lung-resident CD4+ memory T cells that are associated with protection against tuberculosis by Flórido, Manuela, Muflihah, Heni, Lin, Leon C. W., Xia, Yingju, Sierro, Frederic, Palendira, Mainthan, Feng, Carl G., Bertolino, Patrick, Stambas, John, Triccas, James A., Britton, Warwick. J.

“…The lung is the primary site of infection with the major human pathogen, Mycobacterium tuberculosis . Effective vaccines against M. tuberculosis must stimulate…”
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CXCR6-Deficiency Improves the Control of Pulmonary Mycobacterium tuberculosis and Influenza Infection Independent of T-Lymphocyte Recruitment to the Lungs by Ashhurst, Anneliese S, Flórido, Manuela, Lin, Leon C W, Quan, Diana, Armitage, Ellis, Stifter, Sebastian A, Stambas, John, Britton, Warwick J

“…T-lymphocytes are critical for protection against respiratory infections, such as and influenza virus, with chemokine receptors playing an important role in…”
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DIONYSUS: a database of protein-carbohydrate interfaces by Gheeraert, Aria, Bailly, Thomas, Ren, Yani, Hamraoui, Ali, Te, Julie, Vander Meersche, Yann, Cretin, Gabriel, Leon Foun Lin, Ravy, Gelly, Jean-Christophe, Pérez, Serge, Guyon, Frédéric, Galochkina, Tatiana

“…Protein-carbohydrate interactions govern a wide variety of biological processes and play an essential role in the development of different diseases. Here, we…”
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Engineering recombinant poxviruses using a compact GFP–blasticidin resistance fusion gene for selection by Wong, Yik Chun, Lin, Leon C.W., Melo-Silva, Carolina R., Smith, Stewart A., Tscharke, David C.

“…Recombinant poxviruses are important tools for research and some are candidate vaccines. To make these viruses a simple, small vector that can be used to…”
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Integrated Design of a Membrane‐Lytic Peptide‐Based Intravenous Nanotherapeutic Suppresses Triple‐Negative Breast Cancer by Chen, Charles H., Liu, Yu‐Han, Eskandari, Arvin, Ghimire, Jenisha, Lin, Leon Chien‐Wei, Fang, Zih‐Syun, Wimley, William C., Ulmschneider, Jakob P., Suntharalingam, Kogularamanan, Hu, Che‐Ming Jack, Ulmschneider, Martin B.

“…Membrane‐lytic peptides offer broad synthetic flexibilities and design potential to the arsenal of anticancer therapeutics, which can be limited by…”
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Optimizing variant-specific therapeutic SARS-CoV-2 decoys using deep-learning-guided molecular dynamics simulations by Köchl, Katharina, Schopper, Tobias, Durmaz, Vedat, Parigger, Lena, Singh, Amit, Krassnigg, Andreas, Cespugli, Marco, Wu, Wei, Yang, Xiaoli, Zhang, Yanchong, Wang, Welson Wen-Shang, Selluski, Crystal, Zhao, Tiehan, Zhang, Xin, Bai, Caihong, Lin, Leon, Hu, Yuxiang, Xie, Zhiwei, Zhang, Zaihui, Yan, Jun, Zatloukal, Kurt, Gruber, Karl, Steinkellner, Georg, Gruber, Christian C.

“…Treatment of COVID-19 with a soluble version of ACE2 that binds to SARS-CoV-2 virions before they enter host cells is a promising approach, however it needs to…”
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Lymph Node Follicle‐Targeting STING Agonist Nanoshells Enable Single‐Shot M2e Vaccination for Broad and Durable Influenza Protection by Tsai, Hsiao‐Han, Huang, Ping‐Han, Lin, Leon CW, Yao, Bing‐Yu, Liao, Wan‐Ting, Pai, Chen‐Hsueh, Liu, Yu‐Han, Chen, Hui‐Wen, Hu, Che‐Ming J.

“…The highly conserved matrix protein 2 ectodomain (M2e) of influenza viruses presents a compelling vaccine antigen candidate for stemming the pandemic threat of…”
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Immunodomination during peripheral vaccinia virus infection by Lin, Leon C W, Flesch, Inge E A, Tscharke, David C

“…Immunodominance is a fundamental property of CD8(+) T cell responses to viruses and vaccines. It had been observed that route of administration alters…”
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Investigation of pre-bending substrate design in packaging assembly of an IGBT power module by Lee, Chang-Chun, Kao, Kuo-Shu, Lin, Leon, Chang, Jing-Yao, Leu, Fang-Jun, Lu, Yu-Lan, Chang, Tao-Chih

“…•Serious warpage of IGBT power module is induced from assembly processes.•A pre-bending substrate with a curve opposite the warp is proposed.•Design is…”
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Association between tumor architecture derived from generalized Q-space MRI and survival in glioblastoma by Taylor, Erik N, Ding, Yao, Zhu, Shan, Cheah, Eric, Alexander, Phillip, Lin, Leon, Aninwene, 2nd, George E, Hoffman, Matthew P, Mahajan, Anita, Mohamed, Abdallah S R, McDannold, Nathan, Fuller, Clifton D, Chen, Clark C, Gilbert, Richard J

“…While it is recognized that the overall resistance of glioblastoma to treatment may be related to intra-tumor patterns of structural heterogeneity, imaging…”
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A Model for a Standardized and Sustainable Pediatric Anesthesia-Intensive Care Unit Hand-Off Process by Dalal, Priti G., Cios, Theodore J., DeMartini, Theodore K. M., Prasad, Amit A., Whitley, Meghan C., Clark, Joseph B., Lin, Leon, Mujsce, Dennis J., Cilley, Robert E.

“…Background and Objectives: The hand-off process between pediatric anesthesia and intensive care unit (ICU) teams involves the exchange of patient health…”
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An intradermal model for vaccinia virus pathogenesis in mice by Lin, Leon C W, Smith, Stewart A, Tscharke, David C

“…Intradermal injection of vaccinia virus in the ear pinnae of mice provides a model of dermal infection and vaccination. The key features of this model are the…”
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Do NSm Virulence Factors in the Bunyavirales Viral Order Originate from Gn Gene Duplication? by Lefebvre, Victor, Leon Foun Lin, Ravy, Cole, Laura, Cosset, François-Loïc, Fogeron, Marie-Laure, Böckmann, Anja

“…One-third of the nine WHO shortlisted pathogens prioritized for research and development in public health emergencies belong to the order. Several species…”
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