Search Results - "Lin, Kingson"

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    Mechanism-based design of agents that selectively target drug-resistant glioma by Lin, Kingson, Gueble, Susan E, Sundaram, Ranjini K, Huseman, Eric D, Bindra, Ranjit S, Herzon, Seth B

    “…Approximately half of glioblastoma and more than two-thirds of grade II and III glioma tumors lack the DNA repair protein O -methylguanine methyl transferase…”
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  2. 2

    Haloselective Cross-Coupling via Ni/Photoredox Dual Catalysis by Lin, Kingson, Wiles, Rebecca J, Kelly, Christopher B, Davies, Geraint H. M, Molander, Gary A

    Published in ACS catalysis (04-08-2017)
    “…The chemoselective functionalization of polyfunctional aryl linchpins is crucial for rapid diversification. Although well-explored for Csp2 and Csp…”
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    Abstract 1568: Mechanistic studies of KL-50, a novel imidazotetrazine for the treatment of MGMT-/MMR- gliomas and glioblastoma by Huseman, Eric D., Lo, Anna, Fedorova, Olga, Lin, Kingson, Gueble, Susan, Sundaram, Ranjini, Pyle, Anna M., Bindra, Ranjit S., Herzon, Seth

    Published in Cancer research (Chicago, Ill.) (04-04-2023)
    “…Abstract The DNA damage repair protein O6-methylguanine methyl transferase (MGMT) reverses O6-alkylguanine lesions via SN2 transfer of the alkyl lesion to an…”
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    Journal Article