Search Results - "Lin, Kingson"
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Mechanism-based design of agents that selectively target drug-resistant glioma
Published in Science (American Association for the Advancement of Science) (29-07-2022)“…Approximately half of glioblastoma and more than two-thirds of grade II and III glioma tumors lack the DNA repair protein O -methylguanine methyl transferase…”
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Haloselective Cross-Coupling via Ni/Photoredox Dual Catalysis
Published in ACS catalysis (04-08-2017)“…The chemoselective functionalization of polyfunctional aryl linchpins is crucial for rapid diversification. Although well-explored for Csp2 and Csp…”
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Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers
Published in Journal of the American Chemical Society (10-07-2024)“…Aberrant DNA repair is a hallmark of cancer, and many tumors display reduced DNA repair capacities that sensitize them to genotoxins. Here, we demonstrate that…”
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Abstract 1132: Exploiting MGMT loss using a new class of DNA modifiers which selectively target tumor DNA and overcome therapy resistance mechanisms across multiple tumor types
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Abstract DNA damage response (DDR) defects are common in cancer, and it is well established that these tumor-associated DNA repair vulnerabilities can be…”
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Abstract 1568: Mechanistic studies of KL-50, a novel imidazotetrazine for the treatment of MGMT-/MMR- gliomas and glioblastoma
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Abstract The DNA damage repair protein O6-methylguanine methyl transferase (MGMT) reverses O6-alkylguanine lesions via SN2 transfer of the alkyl lesion to an…”
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