Search Results - "Lin, Jonathan H."

Multiple Mechanisms of Unfolded Protein Response–Induced Cell Death by Hiramatsu, Nobuhiko, Chiang, Wei-Chieh, Kurt, Timothy D, Sigurdson, Christina J, Lin, Jonathan H

“…Eukaryotic cells fold and assemble membrane and secreted proteins in the endoplasmic reticulum (ER), before delivery to other cellular compartments or the…”
Get full text

ER stress and unfolded protein response in ocular health and disease by Kroeger, Heike, Chiang, Wei‐Chieh, Felden, Julia, Nguyen, Amanda, Lin, Jonathan H.

“…The human eye is the organ that is able to react to light in order to provide sharp three‐dimensional and colored images. Unfortunately, the health of the eye…”
Get full text

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells by Hollien, Julie, Lin, Jonathan H, Li, Han, Stevens, Nicole, Walter, Peter, Weissman, Jonathan S

“…Maintenance of endoplasmic reticulum (ER) function is achieved in part through Ire1 (inositol-requiring enzyme 1), a transmembrane protein activated by protein…”
Get full text

Divergent effects of PERK and IRE1 signaling on cell viability by Lin, Jonathan H, Li, Han, Zhang, Yuhong, Ron, David, Walter, Peter

“…Protein misfolding in the endoplasmic reticulum (ER) activates a set of intracellular signaling pathways, collectively termed the Unfolded Protein Response…”
Get full text

IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response by Lin, Jonathan H, Li, Han, Yasumura, Douglas, Cohen, Hannah R, Zhang, Chao, Panning, Barbara, Shokat, Kevan M, LaVail, Matthew M, Walter, Peter

“…Endoplasmic reticulum (ER) stress activates a set of signaling pathways, collectively termed the unfolded protein response (UPR). The three UPR branches (IRE1,…”
Get full text

Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells by Rodvold, Jeffrey J, Chiu, Kevin T, Hiramatsu, Nobuhiko, Nussbacher, Julia K, Galimberti, Valentina, Mahadevan, Navin R, Willert, Karl, Lin, Jonathan H, Zanetti, Maurizio

“…Increased protein translation in cells and various factors in the tumor microenvironment can induce endoplasmic reticulum (ER) stress, which initiates the…”
Get more information

Endoplasmic reticulum stress in disease pathogenesis by Lin, Jonathan H, Walter, Peter, Yen, T S Benedict

“…The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and secretory proteins, which, collectively, represent a large fraction of the…”
Get full text

ATF6 is required for efficient rhodopsin clearance and retinal homeostasis in the P23H rho retinitis pigmentosa mouse model by Lee, Eun-Jin, Chan, Priscilla, Chea, Leon, Kim, Kyle, Kaufman, Randal J., Lin, Jonathan H.

“…Retinitis Pigmentosa (RP) is a blinding disease that arises from loss of rods and subsequently cones. The P23H rhodopsin knock-in (P23H-KI) mouse develops…”
Get full text

Rates and timing of subsequent amputation after initial minor amputation by Lin, Jonathan H., Jeon, Sun Young, Romano, Patrick S., Humphries, Misty D.

“…Studies evaluating major amputation after initial minor amputation are few with rates of subsequent major amputation ranging from 14% to 35% with limited…”
Get full text

Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration by Chiang, Wei-Chieh, Kroeger, Heike, Sakami, Sanae, Messah, Carissa, Yasumura, Douglas, Matthes, Michael T., Coppinger, Judith A., Palczewski, Krzysztof, LaVail, Matthew M., Lin, Jonathan H.

“…Rhodopsin is a G protein-coupled receptor essential for vision and rod photoreceptor viability. Disease-associated rhodopsin mutations, such as P23H rhodopsin,…”
Get full text

Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78 by Gorbatyuk, Marina. S., Knox, Tessa, LaVail, Matthew M., Gorbatyuk, Oleg S., Noorwez, Syed M., Hauswirth, William W., Lin, Jonathan H., Muzyczka, Nicholas, Lewin, Alfred S., Berns, Kenneth I.

“…The P23H mutation within the rhodopsin gene (RHO) causes rhodopsin misfolding, endoplasmic reticulum (ER) stress, and activates the unfolded protein response…”
Get full text

Characterization of Retinal Structure in ATF6-Associated Achromatopsia by Mastey, Rebecca R, Georgiou, Michalis, Langlo, Christopher S, Kalitzeos, Angelos, Patterson, Emily J, Kane, Thomas, Singh, Navjit, Vincent, Ajoy, Moore, Anthony T, Tsang, Stephen H, Lin, Jonathan H, Young, Marielle P, Hartnett, M Elizabeth, Héon, Elise, Kohl, Susanne, Michaelides, Michel, Carroll, Joseph

“…Mutations in six genes have been associated with achromatopsia (ACHM): CNGA3, CNGB3, PDE6H, PDE6C, GNAT2, and ATF6. ATF6 is the most recent gene to be…”
Get full text

IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin by Chiang, Wei-Chieh, Messah, Carissa, Lin, Jonathan H

“…Endoplasmic reticulum (ER) is responsible for folding of secreted and membrane proteins in eukaryotic cells. Disruption of ER protein folding leads to ER…”
Get full text

Network biology analysis of P23H rhodopsin interactome identifies protein and mRNA quality control mechanisms by Kim, Kyle, Safarta, Lance A., Chiang, Wei-Chieh J., Coppinger, Judith A., Lee, Eun-Jin, Lin, Jonathan H.

“…Rhodopsin is essential for phototransduction, and many rhodopsin mutations cause heritable retinal degenerations. The P23H rhodopsin variant generates a…”
Get full text

Selective activation of ATF6 and PERK endoplasmic reticulum stress signaling pathways prevent mutant rhodopsin accumulation by Chiang, Wei-Chieh, Hiramatsu, Nobuhiko, Messah, Carissa, Kroeger, Heike, Lin, Jonathan H

“…Many rhodopsin mutations that cause retinitis pigmentosa produce misfolded rhodopsin proteins that are retained within the endoplasmic reticulum (ER) and cause…”
Get full text

Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients by Orrù, Christina D, Soldau, Katrin, Cordano, Christian, Llibre-Guerra, Jorge, Green, Ari J, Sanchez, Henry, Groveman, Bradley R, Edland, Steven D, Safar, Jiri G, Lin, Jonathan H, Caughey, Byron, Geschwind, Michael D, Sigurdson, Christina J

“…Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common prion disease in humans and has been iatrogenically transmitted through corneal graft…”
Get full text

Interpreting Discordant Monosomy 3 FISH and Chromosomal Microarray Analysis Results in Uveal Melanoma by Long, Christopher P, Coley, Nicholas, Thorson, John, Lin, Jonathan H

“…Uveal melanoma is the most common primary ocular tumor in adults and causes morbidity through lymphovascular metastasis. The presence of monosomy 3 in uveal…”
Get full text

IRE1α and IGF signaling predict resistance to an endoplasmic reticulum stress-inducing drug in glioblastoma cells by Rodvold, Jeffrey J., Xian, Su, Nussbacher, Julia, Tsui, Brian, Cameron Waller, T., Searles, Stephen C., Lew, Alyssa, Jiang, Pengfei, Babic, Ivan, Nomura, Natsuko, Lin, Jonathan H., Kesari, Santosh, Carter, Hannah, Zanetti, Maurizio

“…To date current therapies of glioblastoma multiforme (GBM) are largely ineffective. The induction of apoptosis by an unresolvable unfolded protein response…”
Get full text

Conjunctival blue nevus in a child – Case report and review of literature by Yahya, Yasser, Nangia, Purna, Ahmad, Hunain, Frauches, Rachel L., Lin, Jonathan H., Mruthyunjaya, Prithvi

“…To report a rare case of a conjunctival blue nevus in a child. A 10-year-old girl underwent an excisional biopsy for an atypical growing melanocytic…”
Get full text

ER stress in retinal degeneration in S334ter Rho rats by Shinde, Vishal M, Sizova, Olga S, Lin, Jonathan H, LaVail, Matthew M, Gorbatyuk, Marina S

“…The S334ter rhodopsin (Rho) rat (line 4) bears the rhodopsin gene with an early termination codon at residue 334 that is a model for several such mutations…”
Get full text