Search Results - "Lin, Jonathan B."

NAMPT-Mediated NAD+ Biosynthesis Is Essential for Vision In Mice by Lin, Jonathan B., Kubota, Shunsuke, Ban, Norimitsu, Yoshida, Mitsukuni, Santeford, Andrea, Sene, Abdoulaye, Nakamura, Rei, Zapata, Nicole, Kubota, Miyuki, Tsubota, Kazuo, Yoshino, Jun, Imai, Shin-ichiro, Apte, Rajendra S.

“…Photoreceptor death is the endpoint of many blinding diseases. Identifying unifying pathogenic mechanisms in these diseases may offer global approaches for…”
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NAD + -dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism by Porter, Lane C, Franczyk, Michael P, Pietka, Terri, Yamaguchi, Shintaro, Lin, Jonathan B, Sasaki, Yo, Verdin, Eric, Apte, Rajendra S, Yoshino, Jun

“…Mitochondrial dysfunction in adipose tissue is involved in the pathophysiology of obesity-induced systemic metabolic complications, such as type 2 diabetes,…”
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Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration by Ban, Norimitsu, Lee, Tae Jun, Sene, Abdoulaye, Dong, Zhenyu, Santeford, Andrea, Lin, Jonathan B., Ory, Daniel S., Apte, Rajendra S.

“…Photoreceptors have high intrinsic metabolic demand and are exquisitely sensitive to metabolic perturbation. In addition, they shed a large portion of their…”
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Role of Sirtuins in Retinal Function Under Basal Conditions by Lin, Jonathan B, Kubota, Shunsuke, Mostoslavsky, Raul, Apte, Rajendra S

“…Sirtuins are NAD -dependent enzymes that govern cellular homeostasis by regulating the acylation status of their diverse target proteins. We recently…”
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Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration by Lin, Jonathan B, Moolani, Harsh V, Sene, Abdoulaye, Sidhu, Rohini, Kell, Pamela, Lin, Joseph B, Dong, Zhenyu, Ban, Norimitsu, Ory, Daniel S, Apte, Rajendra S

“…Macrophage aging is pathogenic in diseases of the elderly, including age-related macular degeneration (AMD), a leading cause of blindness in older adults…”
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“Complement-ary” Therapies for Age-Related Macular Degeneration by Lin, Jonathan B., Apte, Rajendra S.

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Neuroprotection for Age-Related Macular Degeneration by Lin, Jonathan B., Murakami, Yusuke, Miller, Joan W., Vavvas, Demetrios G.

“…Age-related macular degeneration (AMD) is a leading cause of blindness worldwide. Early to intermediate AMD is characterized by the accumulation of lipid- and…”
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Longitudinal Growth Differentiation Factor 15 (GDF15) and Long-term Intraocular Pressure Fluctuation in Glaucoma: A Pilot Study by Lin, Jonathan B, Sheybani, Arsham, Santeford, Andrea, Apte, Rajendra S

“…Growth Differentiation Factor 15 (GDF15) was previously identified as a molecular marker of retinal ganglion cell stress in rodent models of glaucoma and was…”
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Object and spatial imagery dimensions in visuo-haptic representations by Lacey, Simon, Lin, Jonathan B., Sathian, K.

“…Visual imagery comprises object and spatial dimensions. Both types of imagery encode shape but a key difference is that object imagers are more likely to…”
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Oxysterol Signatures Distinguish Age-Related Macular Degeneration from Physiologic Aging by Lin, Jonathan B., Sene, Abdoulaye, Santeford, Andrea, Fujiwara, Hideji, Sidhu, Rohini, Ligon, Marianne M., Shankar, Vikram A., Ban, Norimitsu, Mysorekar, Indira U., Ory, Daniel S., Apte, Rajendra S.

“…Macrophage aging is pathogenic in numerous diseases, including age-related macular degeneration (AMD), a leading cause of blindness in older adults. Although…”
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Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice by Yoshida, Mitsukuni, Satoh, Akiko, Lin, Jonathan B., Mills, Kathryn F., Sasaki, Yo, Rensing, Nicholas, Wong, Michael, Apte, Rajendra S., Imai, Shin-ichiro

“…Aging is a significant risk factor for impaired tissue functions and chronic diseases. Age-associated decline in systemic NAD+ availability plays a critical…”
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GDF15 is elevated in mice following retinal ganglion cell death and in glaucoma patients by Ban, Norimitsu, Siegfried, Carla J, Lin, Jonathan B, Shui, Ying-Bo, Sein, Julia, Pita-Thomas, Wolfgang, Sene, Abdoulaye, Santeford, Andrea, Gordon, Mae, Lamb, Rachel, Dong, Zhenyu, Kelly, Shannon C, Cavalli, Valeria, Yoshino, Jun, Apte, Rajendra S

“…Glaucoma is the second leading cause of blindness worldwide. Physicians often use surrogate endpoints to monitor the progression of glaucomatous…”
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Loss of form vision impairs spatial imagery by Occelli, Valeria, Lin, Jonathan B, Lacey, Simon, Sathian, K

“…Previous studies have reported inconsistent results when comparing spatial imagery performance in the blind and the sighted, with some, but not all, studies…”
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Corrigendum: Loss of form vision impairs spatial imagery by Occelli, Valeria, Lin, Jonathan B., Lacey, Simon, Sathian, K.

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OCT Angiography Findings in Preclinical Alzheimer’s Disease: 3-Year Follow-Up by O’Bryhim, Bliss Elizabeth, Lin, Jonathan B., Van Stavern, Gregory P., Apte, Rajendra S.

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Preoperative electrophysiological characterization of patients with primary macula-involving rhegmatogenous retinal detachment by Lin, Jonathan, Sein, Julia, Van Stavern, Gregory, Apte, Rajendra

“…Purpose: To determine 1) which components of retinal function are impaired after rhegmatogenous retinal detachment, 2) which outer retinal pathways (rod- or…”
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Seeing Parkinson Disease in the Retina by Lin, Jonathan B, Apte, Rajendra S

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Short-Wavelength Light-Blocking Eyeglasses Attenuate Symptoms of Eye Fatigue by Lin, Jonathan B, Gerratt, Blair W, Bassi, Carl J, Apte, Rajendra S

“…The purpose of this study was to determine whether subjects who wear short wavelength-blocking eyeglasses during computer tasks exhibit less visual fatigue and…”
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Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss by Ban, Norimitsu, Lee, Tae Jun, Sene, Abdoulaye, Choudhary, Mayur, Lekwuwa, Michael, Dong, Zhenyu, Santeford, Andrea, Lin, Jonathan B., Malek, Goldis, Ory, Daniel S., Apte, Rajendra S.

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NAD+ and sirtuins in retinal degenerative diseases: A look at future therapies by Lin, Jonathan B., Apte, Rajendra S.

“…Retinal degenerative diseases are a major cause of morbidity in modern society because visual impairment significantly decreases the quality of life of…”
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