Search Results - "Lin, Jasper C"

A pre-existing hydrophobic collapse in the unfolded state of an ultrafast folding protein by HUN MOK, K, KUHN, Lars T, GOEZ, Martin, DAY, Iain J, LIN, Jasper C, ANDERSEN, Niels H, HORE, P. J

“…Insights into the conformational passage of a polypeptide chain across its free energy landscape have come from the judicious combination of experimental…”
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High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance by Nguyen, Phuong-Cac T., Lewis, Kenneth B., Ettinger, Ruth A., Schuman, Jason T., Lin, Jasper C., Healey, John F., Meeks, Shannon L., Lollar, Pete, Pratt, Kathleen P.

“…Neutralizing anti-factor VIII (FVIII) antibodies that develop in patients with hemophilia A and in murine hemophilia A models, clinically termed “inhibitors,”…”
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Crystal and NMR structures of a Trp-cage mini-protein benchmark for computational fold prediction by Scian, Michele, Lin, Jasper C, Le Trong, Isolde, Makhatadze, George I, Stenkamp, Ronald E, Andersen, Niels H

“…To provide high-resolution X-ray crystallographic structures of a peptide with the Trp-cage fold, we prepared a cyclized version of this motif. Cyclized…”
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Six amino acid residues in a 1200 Å2 interface mediate binding of factor VIII to an IgG4κ inhibitory antibody by Lin, Jasper C, Ettinger, Ruth A, Schuman, Jason T, Zhang, Ai-Hong, Wamiq-Adhami, Muhammad, Nguyen, Phuong-Cac T, Nakaya-Fletcher, Shelley M, Puranik, Komal, Thompson, Arthur R, Pratt, Kathleen P

“…The development of neutralizing anti-factor VIII (FVIII) antibodies complicates the treatment of many hemophilia A patients. The C-terminal C2 domain is a…”
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Assessing the Utility of Circular Dichroism and FTIR Spectroscopy in Monoclonal-Antibody Comparability Studies by Lin, Jasper C, Glover, Zephania Kwong, Sreedhara, Alavattam

“…Protein characterization is a necessary activity during development, technical transfers, and licensure. One important aspect of protein characterization is…”
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Best Practices for Aggregate Quantitation of Antibody Therapeutics by Sedimentation Velocity Analytical Ultracentrifugation by Bou-Assaf, George M, Budyak, Ivan L, Brenowitz, Michael, Day, Eric S, Hayes, David, Hill, John, Majumdar, Ranajoy, Ringhieri, Paola, Schuck, Peter, Lin, Jasper C

“…Analytical ultracentrifugation (AUC) is a critical analytical tool supporting the development and manufacture of protein therapeutics. AUC is routinely used as…”
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Measurement and Characterization of Hydrogen–Deuterium Exchange Chemistry Using Relaxation Dispersion NMR Spectroscopy by Khirich, Gennady, Holliday, Michael J, Lin, Jasper C, Nandy, Aditya

“…One-dimensional heteronuclear relaxation dispersion NMR spectroscopy at 13C natural abundance successfully characterized the dynamics of the hydrogen–deuterium…”
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The Trp-cage: optimizing the stability of a globular miniprotein by Barua, Bipasha, Lin, Jasper C., Williams, Victoria D., Kummler, Phillip, Neidigh, Jonathan W., Andersen, Niels H.

“…The Trp-cage, as the smallest miniprotein, remains the subject of numerous computational and experimental studies of protein folding dynamics and pathways. The…”
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The Helical Alanine Controversy:  An (Ala)6 Insertion Dramatically Increases Helicity by Lin, Jasper C, Barua, Bipasha, Andersen, Niels H

“…Employing chemical shift melts and hydrogen/deuterium exchange NMR techniques, we have determined the stabilization of the Trp-cage miniprotein due to multiple…”
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Lysine and arginine residues do not increase the helicity of alanine-rich peptide helices by Stewart, James M, Lin, Jasper C, Andersen, Niels H

“…The helix-disfavoring, versus alanine, propagation values of lysine (0.8) and arginine (1.0) residues placed centrally in an (Ala)(9) unit have been measured…”
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Optimizing the fold stability of miniprotein sequences by Williams, D Victoria, Lin, Jasper C, Kier, Brandon L, Andersen, Niels H

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B-Cell Epitope Mapping of Monoclonal Anti-Factor VIII C2 Domain Inhibitors: Identification of Amino Acids That Contribute Significant Antigen-Antibody Binding Affinity by Lin, Jasper C., Schuman, Jason T., Meeks, Shannon L., Healey, John F., Thompson, Arthur R., Pratt, Kathleen P.

“…The most troublesome clinical complication that can afflict hemophilia A patients who receive factor VIII (FVIII) infusions as replacement therapy is the…”
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Six Amino Acid Residues in a 1200 Å2 Interface Mediate Binding of Factor VIII to An IgG4 Inhibitory Antibody by Lin, Jasper C., Schuman, Jason T., Nakaya, Shelley M., Kaushik, Vasudha, Jacquemin, Marc, Thompson, Arthur R., Pratt, Kathleen P.

“…Approximately one quarter of severe hemophilia A patients who receive Factor VIII (FVIII) injections develop antibodies, clinically referred to as…”
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Six Amino Acid Residues in a 1200 Å2 Interface Mediate Binding of Factor VIII to An IgG4 Inhibitory Antibody by Lin, Jasper C., Schuman, Jason T., Nakaya, Shelley M., Kaushik, Vasudha, Jacquemin, Marc, Thompson, Arthur R., Pratt, Kathleen P.

“…Abstract Approximately one quarter of severe hemophilia A patients who receive Factor VIII (FVIII) injections develop antibodies, clinically referred to as…”
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