A redox homeostasis disruptor based on a biodegradable nanoplatform for ultrasound (US) imaging-guided high-performance ferroptosis therapy of tumors

The synergistic disruption of intracellular redox homeostasis through the combination of ferroptosis/gas therapy shows promise in enhancing the antitumor efficacy. However, the development of an optimal delivery system encounters significant challenges, including effective storage, precise delivery,...

Full description

Saved in:

Bibliographic Details
Published in:	Science and technology of advanced materials Vol. 25; no. 1; p. 2351354
Main Authors:	Li, Xia, Lin, Huijian, Hu, Jianbo, Fang, Jiajin, Liu, Hongsheng, Fu, Can, Zhao, Kewei
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis Group 2024
Subjects:	CO bubble ferroptosis therapy Hollow mesoporous organosilica nanoparticle tumor microenvironment ultrasound imaging ultrasound imaging ferroptosis therapy tumor microenvironment Hollow mesoporous organosilica nanoparticle CO bubble
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The synergistic disruption of intracellular redox homeostasis through the combination of ferroptosis/gas therapy shows promise in enhancing the antitumor efficacy. However, the development of an optimal delivery system encounters significant challenges, including effective storage, precise delivery, and controlled release of therapeutic gas. In this study, we propose the utilization of a redox homeostasis disruptor that is selectively activated by the tumor microenvironment (TME), in conjunction with our newly developed nanoplatforms (MC@HMOS@Au@RGD), for highly efficient ferroptosis therapy of tumors. The TME-triggered degradation of HMOS initiates the release of MC and AuNPs from the MC@HMOS@Au@RGD nanoplatform. The released MC subsequently reacts with endogenous hydrogen peroxide (H O ) and H to enable the on-demand release of CO gas, leading to mitochondrial damage. Simultaneously, the released AuNPs exhibit GOx-like activity, catalyzing glucose to generate gluconic acid and H O . This process not only promotes the decomposition of MnCO to enhance CO production but also enhances the Fenton-like reaction between Mn and H O , generating ROS through the modulation of the H and H O -enriched TME. Moreover, the generation of CO bubbles enables the monitoring of the ferroptosis treatment process through ultrasound (US) imaging. The efficacy of our prepared MC@HMOS@Au@RGD disruptors in ferroptosis therapy is validated through both and experiments.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1468-6996 1878-5514
DOI:	10.1080/14686996.2024.2351354