Search Results - "Lin, Dawn S."

IFlowPlate—A Customized 384‐Well Plate for the Culture of Perfusable Vascularized Colon Organoids by Rajasekar, Shravanthi, Lin, Dawn S. Y., Abdul, Lyan, Liu, Amy, Sotra, Alexander, Zhang, Feng, Zhang, Boyang

“…Despite the complexity and structural sophistication that 3D organoid models provide, their lack of vascularization and perfusion limit the capability of these…”
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Subtractive manufacturing with swelling induced stochastic folding of sacrificial materials for fabricating complex perfusable tissues in multi-well plates by Rajasekar, Shravanthi, Lin, Dawn S Y, Zhang, Feng, Sotra, Alexander, Boshart, Alex, Clotet-Freixas, Sergi, Liu, Amy, Hirota, Jeremy A, Ogawa, Shinichiro, Konvalinka, Ana, Zhang, Boyang

“…Organ-on-a-chip systems that recapitulate tissue-level functions have been proposed to improve - correlation in drug development. Significant progress has been…”
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From Model System to Therapy: Scalable Production of Perfusable Vascularized Liver Spheroids in “Open-Top“ 384-Well Plate by Lin, Dawn S. Y, Rajasekar, Shravanthi, Marway, Mandeep Kaur, Zhang, Boyang

“…Vasculature is a key component of many biological tissues and helps to regulate a wide range of biological processes. Modeling vascular networks or the…”
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DiSNE Movie Visualization and Assessment of Clonal Kinetics Reveal Multiple Trajectories of Dendritic Cell Development by Lin, Dawn S., Kan, Andrey, Gao, Jerry, Crampin, Edmund J., Hodgkin, Philip D., Naik, Shalin H.

“…A thorough understanding of cellular development is incumbent on assessing the complexities of fate and kinetics of individual clones within a population…”
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Modeling organ-specific vasculature with organ-on-a-chip devices by Lin, Dawn S Y, Guo, Feng, Zhang, Boyang

“…Organ-on-a-chip devices, also known as microphysiological systems, have gained significant attention in recent years. Recent advances in tissue engineering and…”
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Expanding hematopoietic stem cell ex vivo: recent advances and technical considerations by Rubio-Lara, Juan A., Igarashi, Kyomi J., Sood, Shubhankar, Johansson, Alban, Sommerkamp, Pia, Yamashita, Masayuki, Lin, Dawn S.

“…•Synthetic polymers such as polyvinyl alcohol can replace serum albumin to induce long-term ex vivo hematopoietic stem cell (HSC) expansion.•Mesenchymal…”
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New insight into the causes, consequences, and correction of hematopoietic stem cell aging by Mansell, Els, Lin, Dawn S., Loughran, Stephen J., Milsom, Michael D., Trowbridge, Jennifer J.

“…•Low-grade inflammation in early to mid-life accelerates mouse hematopoietic aging•The decline of niche factor insulin-like growth factor 1 drives the onset of…”
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Therapeutic luminal coating of the intestine by Lee, Yuhan, Deelman, Tara E., Chen, Keyue, Lin, Dawn S. Y., Tavakkoli, Ali, Karp, Jeffrey M.

“…The gastrointestinal tract is the site of most drug delivery and therapeutic interventions for the management and treatment of numerous diseases. However,…”
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Differential expression of endothelial protein C receptor (EPCR) in hematopoietic stem and multipotent progenitor cells in young and old mice by Lin, Dawn S., Trumpp, Andreas

“…Endothelial protein C receptor (EPCR) has emerged as one of the most conserved and reliable surface markers for the prospective identification and isolation of…”
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Trained immunity and epigenetic memory in long-term self-renewing hematopoietic cells by Johansson, Alban, Lin, Dawn S., Mercier, Francois E., Yamashita, Masayuki, Divangahi, Maziar, Sieweke, Michael H.

“…•Trained immunity is a long-term memory-like response in innate immune cells.•Direct pathogen sensing or indirect environmental alteration induce trained…”
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Ever-evolving insights into the cellular and molecular drivers of lymphoid cell development by Tran, Vu L., Haltalli, Myriam L.R., Li, Jingjing, Lin, Dawn S., Yamashita, Masayuki, Naik, Shalin H., Rothenberg, Ellen V.

“…Lymphocytes play a critical role in adaptive immunity and defense mechanisms, but the molecular mechanisms by which hematopoietic stem and progenitor cells…”
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Pump-Less Platform Enables Long-Term Recirculating Perfusion of 3D Printed Tubular Tissues by Zhang, Feng, Lin, Dawn S Y, Rajasekar, Shravanthi, Sotra, Alexander, Zhang, Boyang

“…The direction and pattern of fluid flow affect vascular structure and function, in which vessel-lining endothelial cells exhibit variable cellular morphologies…”
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Microfluidics: IFlowPlate—A Customized 384‐Well Plate for the Culture of Perfusable Vascularized Colon Organoids (Adv. Mater. 46/2020) by Rajasekar, Shravanthi, Lin, Dawn S. Y., Abdul, Lyan, Liu, Amy, Sotra, Alexander, Zhang, Feng, Zhang, Boyang

“…Human stem‐cell‐derived organoids have provided new opportunities to model biological processes and recapitulate organ development. However, organoid systems…”
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Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development by Tian, Luyi, Tomei, Sara, Schreuder, Jaring, Weber, Tom S., Amann-Zalcenstein, Daniela, Lin, Dawn S., Tran, Jessica, Audiger, Cindy, Chu, Mathew, Jarratt, Andrew, Willson, Tracy, Hilton, Adrienne, Pang, Ee Shan, Patton, Timothy, Kelly, Madison, Su, Shian, Gouil, Quentin, Diakumis, Peter, Bahlo, Melanie, Sargeant, Toby, Kats, Lev M., Hodgkin, Philip D., O’Keeffe, Meredith, Ng, Ashley P., Ritchie, Matthew E., Naik, Shalin H.

“…Despite advances in single-cell multi-omics, a single stem or progenitor cell can only be tested once. We developed clonal multi-omics, in which daughters of a…”
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Single-cell analyses reveal the clonal and molecular aetiology of Flt3L-induced emergency dendritic cell development by Lin, Dawn S., Tian, Luyi, Tomei, Sara, Amann-Zalcenstein, Daniela, Baldwin, Tracey M., Weber, Tom S., Schreuder, Jaring, Stonehouse, Olivia J., Rautela, Jai, Huntington, Nicholas D., Taoudi, Samir, Ritchie, Matthew E., Hodgkin, Philip D., Ng, Ashley P., Nutt, Stephen L., Naik, Shalin H.

“…Regulation of haematopoietic stem and progenitor cell (HSPC) fate is crucial during homeostasis and under stress conditions. Here we examine the aetiology of…”
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A new lymphoid-primed progenitor marked by Dach1 downregulation identified with single cell multi-omics by Amann-Zalcenstein, Daniela, Tian, Luyi, Schreuder, Jaring, Tomei, Sara, Lin, Dawn S., Fairfax, Kirsten A., Bolden, Jessica E., McKenzie, Mark D., Jarratt, Andrew, Hilton, Adrienne, Jackson, Jacob T., Di Rago, Ladina, McCormack, Matthew P., de Graaf, Carolyn A., Stonehouse, Olivia, Taoudi, Samir, Alexander, Warren S., Nutt, Stephen L., Ritchie, Matthew E., Ng, Ashley P., Naik, Shalin H.

“…A classical view of blood cell development is that multipotent hematopoietic stem and progenitor cells (HSPCs) become lineage-restricted at defined stages. Lin…”
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Single-cell lineage tracing approaches in hematology research: technical considerations by Carrelha, Joana, Lin, Dawn S., Rodriguez-Fraticelli, Alejo E., Luis, Tiago C., Wilkinson, Adam C., Cabezas-Wallscheid, Nina, Tremblay, Cedric S., Haas, Simon

“…•Clonal lineage tracing approaches for studying hematopoiesis are described.•Single-cell transplantation assays and lentiviral barcoding technologies are…”
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Macrophage Immunomodulation Through New Polymers that Recapitulate Functional Effects of Itaconate as a Power House of Innate Immunity by Davenport Huyer, Locke, Mandla, Serena, Wang, Yufeng, Campbell, Scott B., Yee, Bess, Euler, Christian, Lai, Benjamin F., Bannerman, A. Dawn, Lin, Dawn S. Y., Montgomery, Miles, Nemr, Kayla, Bender, Timothy, Epelman, Slava, Mahadevan, Radhakrishnan, Radisic, Milica

“…Itaconate (ITA) is an emerging powerhouse of innate immunity with therapeutic potential that is limited in its ability to be administered in a soluble form. A…”
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