Search Results - "Lin, David S"

DNA methylation signatures of youth-onset type 2 diabetes and exposure to maternal diabetes by Salama, Ola E, Hizon, Nikho, Del Vecchio, Melissa, Kolsun, Kurt, Fonseca, Mario A, Lin, David T S, Urtatiz, Oscar, MacIsaac, Julia L, Kobor, Michael S, Sellers, Elizabeth A C, Dolinsky, Vernon W, Dart, Allison B, Jones, Meaghan J, Wicklow, Brandy A

“…Youth-onset type 2 diabetes (T2D) is physiologically distinct from adult-onset, but it is not clear how the two diseases differ at a molecular level. In utero…”
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Maternal blood contamination of collected cord blood can be identified using DNA methylation at three CpGs by Morin, Alexander M, Gatev, Evan, McEwen, Lisa M, MacIsaac, Julia L, Lin, David T S, Koen, Nastassja, Czamara, Darina, Räikkönen, Katri, Zar, Heather J, Koenen, Karestan, Stein, Dan J, Kobor, Michael S, Jones, Meaghan J

“…Cord blood is a commonly used tissue in environmental, genetic, and epigenetic population studies due to its ready availability and potential to inform on a…”
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Reversal of epigenetic aging and immunosenescent trends in humans by Fahy, Gregory M., Brooke, Robert T., Watson, James P., Good, Zinaida, Vasanawala, Shreyas S., Maecker, Holden, Leipold, Michael D., Lin, David T. S., Kobor, Michael S., Horvath, Steve

“…Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological age. Here, we use four such age estimators to show that epigenetic…”
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The Blood DNA Methylation Clock GrimAge Is a Robust Surrogate for Airway Epithelia Aging by Hernandez Cordero, Ana I, Yang, Chen Xi, Li, Xuan, Yang, Julia, Shaipanich, Tawimas, MacIsaac, Julie L, Lin, David T S, Kobor, Michael S, Horvath, Steve, Man, Shu Fan Paul, Sin, Don D, Leung, Janice M

“…One key feature of Chronic Obstructive Pulmonary Disease (COPD) is that its prevalence increases exponentially with age. DNA methylation clocks have become…”
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The immune factors driving DNA methylation variation in human blood by Bergstedt, Jacob, Azzou, Sadoune Ait Kaci, Tsuo, Kristin, Jaquaniello, Anthony, Urrutia, Alejandra, Rotival, Maxime, Lin, David T. S., MacIsaac, Julia L., Kobor, Michael S., Albert, Matthew L., Duffy, Darragh, Patin, Etienne, Quintana-Murci, Lluís

“…Epigenetic changes are required for normal development, yet the nature and respective contribution of factors that drive epigenetic variation in humans remain…”
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Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging by Verschoor, Chris P, Lin, David T S, Kobor, Michael S, Mian, Oxana, Ma, Jinhui, Pare, Guillaume, Ybazeta, Gustavo

“…The trajectory of frailty in older adults is important to public health; therefore, markers that may help predict this and other important outcomes could be…”
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Perinatally acquired HIV infection accelerates epigenetic aging in South African adolescents by Horvath, Steve, Stein, Dan J, Phillips, Nicole, Heany, Sarah J, Kobor, Michael S, Lin, David T.S, Myer, Landon, Zar, Heather J, Levine, Andrew J, Hoare, Jacqueline

“…OBJECTIVE:Recent studies demonstrate that infection with the HIV-1 is associated with accelerated aging effects in adults according to a highly accurate…”
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Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways by Schaffner, Samantha L, Wassouf, Zinah, Lazaro, Diana F, Xylaki, Mary, Gladish, Nicole, Lin, David T S, MacIsaac, Julia, Ramadori, Katia, Hentrich, Thomas, Schulze-Hentrich, Julia M, Outeiro, Tiago F, Kobor, Michael S

“…Parkinson's disease (PD) is a neurological disorder with complex interindividual etiology that is becoming increasingly prevalent worldwide. Elevated…”
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Methylation of cysteinyl leukotriene receptor 1 genes associates with lung function in asthmatics exposed to traffic-related air pollution by Rabinovitch, Nathan, Jones, Meaghan J., Gladish, Nicole, Faino, Anna V., Strand, Matthew, Morin, Alexander M., MacIsaac, Julie, Lin, David T. S., Reynolds, Paul R., Singh, Amrit, Gelfand, Erwin W., Kobor, Michael S., Carlsten, Christopher

“…Air pollution is associated with early declines in lung function and increased levels of asthma-related cysteinyl leukotrienes (CysLT) but a biological pathway…”
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A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment by Toepfer, Philipp, O'Donnell, Kieran J., Entringer, Sonja, Heim, Christine M., Lin, David T.S., MacIsaac, Julia L., Kobor, Michael S., Meaney, Michael J., Provençal, Nadine, Binder, Elisabeth B., Wadhwa, Pathik D., Buss, Claudia

“…Women exposed to childhood maltreatment (CM) are more likely to exhibit insensitive parenting, which may have consequences for their offspring’s development…”
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Maternal psychosocial risk factors and child gestational epigenetic age in a South African birth cohort study by Koen, Nastassja, Jones, Meaghan J., Nhapi, Raymond T., Lake, Marilyn T., Donald, Kirsten A., Barnett, Whitney, Hoffman, Nadia, MacIsaac, Julia L., Morin, Alexander M., Lin, David T. S., Kobor, Michael S., Koenen, Karestan C., Zar, Heather J., Stein, Dan J.

“…Accelerated epigenetic aging relative to chronological age has been found to be associated with higher risk of mortality in adults. However, little is known…”
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Newborn differential DNA methylation and subcortical brain volumes as early signs of severe neurodevelopmental delay in a South African Birth Cohort Study by Hüls, Anke, Wedderburn, Catherine J., Groenewold, Nynke A., Gladish, Nicole, Jones, Meaghan J., Koen, Nastassja, MacIsaac, Julia L., Lin, David T. S., Ramadori, Katia E., Epstein, Michael P., Donald, Kirsten A., Kobor, Michael S., Zar, Heather J., Stein, Dan J.

“…Early detection of neurodevelopmental delay is crucial for intervention and treatment strategies. We analysed associations between newborn DNA methylation…”
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Sex differences in epigenetic age in Mediterranean high longevity regions by Engelbrecht, Hannah-Ruth, Merrill, Sarah M, Gladish, Nicole, MacIsaac, Julie L, Lin, David T S, Ecker, Simone, Chrysohoou, Christina A, Pes, Giovanni M, Kobor, Michael S, Rehkopf, David H

“…Sex differences in aging manifest in disparities in disease prevalence, physical health, and lifespan, where women tend to have greater longevity relative to…”
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Hodgkin’s lymphoma of the breast with involvement of the brachial plexus by Lin, David S, Dalal, Ishani

“…[...]there must not be evidence of concurrent widespread disease or preceding extramammary lymphoma at diagnosis. Five cases in their study were classified as…”
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Pituitary metastasis from lung carcinoma presenting as a pituitary adenoma by Lin, David S, Griffith, Brent, Patel, Suresh, Rock, Jack, Marin, Horia

“…DISCUSSION Pituitary metastases are rare, most commonly encountered in the 6th and 7th decades of life with no predilection for gender.1 In a recent literature…”
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Maternal epigenetic clocks measured during pregnancy do not predict gestational age at delivery or offspring birth outcomes: a replication study in metropolitan Cebu, Philippines by Ryan, Calen P, Rege, Raviraj J, Lee, Nanette R, Carba, Delia B, Kobor, Michael S, MacIsaac, Julie L, Lin, David S, Atashzay, Parmida, Kuzawa, Christopher W

“…Adverse birth outcomes, such as early gestational age and low birth weight, can have lasting effects on morbidity and mortality, with impacts that persist into…”
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Intracellular calcium and calmodulin link brain-derived neurotrophic factor to p70S6 kinase phosphorylation and dendritic protein synthesis by Zhou, Xianju, Lin, David S., Zheng, Fei, Sutton, Michael A., Wang, Hongbing

“…The mammalian target of rapamycin (mTOR)/p70S6 kinase (S6K) pathway plays an important role in brain‐derived neurotrophic factor (BDNF)‐mediated protein…”
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Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion by Lamarche, Caroline, Ward-Hartstonge, Kirsten, Mi, Tian, Lin, David T S, Huang, Qing, Brown, Andrew, Edwards, Karlie, Novakovsky, Gherman E, Qi, Christopher N, Kobor, Michael S, Zebley, Caitlin C, Weber, Evan W, Mackall, Crystal L, Levings, Megan K

“…Regulatory T cell (Treg) therapy is a promising approach to improve outcomes in transplantation and autoimmunity. In conventional T cell therapy, chronic…”
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Particle Depletion Does Not Remediate Acute Effects of Traffic-related Air Pollution and Allergen. A Randomized, Double-Blind Crossover Study by Wooding, Denise J, Ryu, Min Hyung, Hüls, Anke, Lee, Andrew D, Lin, David T S, Rider, Christopher F, Yuen, Agnes C Y, Carlsten, Chris

“…Diesel exhaust (DE), an established model of traffic-related air pollution, contributes significantly to the global burden of asthma and may augment the…”
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Pregnancy is linked to faster epigenetic aging in young women by Ryan, Calen P, Lee, Nanette R, Carba, Delia B, MacIsaac, Julie L, Lin, David T S, Atashzay, Parmida, Belsky, Daniel W, Kobor, Michael S, Kuzawa, Christopher W

“…A central prediction of evolutionary theory is that energy invested into reproduction comes at the expense of somatic maintenance and repair, accelerating…”
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