Search Results - "Lin, Chii M"

Synthesis and evaluation of analogs of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents by Cushman, Mark, Nagarathnam, Dhanapalan, Gopal, D, He, Hu Ming, Lin, Chii M, Hamel, Ernest

“…A series of stilbenes has been prepared and tested for cytotoxicity in the five human cancer cell lines A-549 non-small cell lung, MCF-7 breast, HT-29 colon,…”
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Antitumor Agents 155. Synthesis and Biological Evaluation of 3',6,7-Substituted 2-Phenyl-4-quinolones as Antimicrotubule Agents by Li, Leping, Wang, Hui-Kang, Kuo, Sheng-Chu, Wu, Tian-Shung, Mauger, Anthony, Lin, Chii M, Hamel, Ernest, Lee, Kuo-Hsiung

“…A series of 3',6,7-substituted 2-phenyl-4-quinolones were designed and synthesized as antimitotic antitumor agents. All compounds showed cytotoxic effects (log…”
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Antitumor Agents, 154. Cytotoxic and Antimitotic Flavonols from Polanisia dodecandra by Shi, Qian, Chen, Ke, Li, Leping, Chang, Jer-Jang, Autry, Cari, Kozuka, Mutsuo, Konoshima, Takao, Estes, James R, Lin, Chii M, Hamel, Ernest, McPhail, Andrew T, McPhail, Donald R, Lee, Kao-Hsiung

“…Three flavonols, 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone [1], 5,4'-dihydroxy-3,6,7,8,3'-pentamethoxyflavone [2], and quercetin…”
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Discodermolide, A Cytotoxic Marine Agent That Stabilizes Microtubules More Potently Than Taxol by ter Haar, Ernst, Kowalski, Richard J, Hamel, Ernest, Lin, Chii M, Longley, Ross E, Gunasekera, Sarath P, Rosenkranz, Herbert S, Day, Billy W

“…Computer-assisted structure analysis indicated (+)-discodermolide, a polyhydroxylated alkatetraene lactone marine natural product, was an antimitotic compound,…”
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2-Methoxyestradiol, an Endogenous Mammalian Metabolite, Inhibits Tubulin Polymerization by Interacting at the Colchicine Site by D'Amato, Robert J., Lin, Chii M., Flynn, Evelyn, Folkman, Judah, Hamel, Ernest

“…A metabolite of estradiol, 2-methoxyestradiol (2ME), inhibits angiogenesis in the chicken embryo chorioallantoic membrane assay. Since 2ME causes mitotic…”
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Synthesis, Antitubulin and Antimitotic Activity, and Cytotoxicity of Analogs of 2-Methoxyestradiol, an Endogenous Mammalian Metabolite of Estradiol That Inhibits Tubulin Polymerization by Binding to the Colchicine Binding Site by Cushman, Mark, He, Hu-Ming, Katzenellenbogen, John A, Lin, Chii M, Hamel, Ernest

“…In order to define the structural parameters associated with the antitubulin activity and cytotoxicity of 2-methoxyestradiol, a mammalian metabolite of…”
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Antitumor Agents. 178. † Synthesis and Biological Evaluation of Substituted 2-Aryl-1,8-naphthyridin-4(1H)-ones as Antitumor Agents That Inhibit Tubulin Polymerization by Chen, Ke, Kuo, Sheng-Chu, Hsieh, Ming-Chieh, Mauger, Anthony, Lin, Chii M, Hamel, Ernest, Lee, Kuo-Hsiung

“…As part of our continuing search for potential anticancer drug candidates in the 2-aryl-1,8-naphthyridin-4(1H)-one series, we have synthesized two series of…”
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Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization by Cushman, Mark, Nagarathnam, Dhanapalan, Gopal, D, Chakraborti, Asit K, Lin, Chii M, Hamel, Ernest

“…An array of cis-, trans-, and dihydrostilbenes and some N-arylbenzylamines were synthesized and evaluated for their cytotoxicity in the five cancer cell…”
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Antitumor Agents. 174. 2‘,3‘,4‘,5,6,7-Substituted 2-Phenyl-1,8-naphthyridin-4-ones:  Their Synthesis, Cytotoxicity, and Inhibition of Tubulin Polymerization by Chen, Ke, Kuo, Sheng-Chu, Hsieh, Ming-Chieh, Mauger, Anthony, Lin, Chii M, Hamel, Ernest, Lee, Kuo-Hsiung

“…Two series of 2‘,3‘,4‘,5,6,7-substituted 2-phenyl-1,8-naphthyridin-4-ones and 2-phenylpyrido[1,2-a]pyrimidin-4-ones have been synthesized and evaluated as…”
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Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin by Lin, Chii M, Ho, Holly H, Pettit, George R, Hamel, Ernest

“…Combretastatin A-4 (CS-A4), 3,4,5-trimethoxy-3'-hydroxy-4'-methoxy-(Z)-stilbene, and combretastatin A-2 (CS-A2),…”
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Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin by Kuo, Sheng Chu, Lee, Hong Zin, Juang, Jung Pin, Lin, Yih Tyng, Wu, Tian Shung, Chang, Jer Jang, Lednicer, Dan, Paull, Kenneth D, Lin, Chii M

“…A series of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds have been synthesized and evaluated as cytotoxic compounds and as…”
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Interactions of 2-Methoxyestradiol, an Endogenous Mammalian Metabolite, with Unpolymerized Tubulin and with Tubulin Polymers by Hamel, Ernest, Lin, Chii M, Flynn, Evelyn, D'Amato, Robert J

“…2-Methoxyestradiol (2ME) is an endogenous mammalian catabolite of estradiol with antimitotic activity. Although it is a competitive inhibitor of the binding of…”
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Isolation, Structure, Synthesis, and Antimitotic Properties of Combretastatins B-3 and B-4 from Combretum caffrum by Pettit, George R, Singh, Sheo Bux, Schmidt, Jean M, Nixen, Margaret L, Hamel, Ernest, Lin, Chii M

“…Further investigation of a CH2Cl2 fraction prepared from the South African tree Combretum caffrum for substances inhibitory to the murine P-388 lymphocytic…”
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Synthesis of Analogs of 2-Methoxyestradiol with Enhanced Inhibitory Effects on Tubulin Polymerization and Cancer Cell Growth by Cushman, Mark, He, Hu-Ming, Katzenellenbogen, John A, Varma, Ravi K, Hamel, Ernest, Lin, Chii M, Ram, Siya, Sachdeva, Yesh P

“…A new series of estradiol analogs was synthesized in an attempt to improve on the anticancer activity of 2-methoxyestradiol, a naturally occurring mammalian…”
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Two New Cytotoxic Chalcones from Calythropsis aurea by Beutler, John A, Cardellina, John H, Gray, Glenn N, Prather, Tanya R, Shoemaker, Robert H, Boyd, Michael R, Lin, Chii M, Hamel, Ernest, Cragg, Gordon M

“…The crude extract of Calythropsis aurea (Myrtaceae) produced a pattern of differential cytotoxicity in the NCI 60 cell line assay which was similar to those of…”
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Antitumor Agents. 150. 2',3',4',5',5,6,7-Substituted 2-Phenyl-4-quinolones and Related Compounds: Their Synthesis, Cytotoxicity, and Inhibition of Tubulin Polymerization by Li, Leping, Wang, Hui-Kang, Kuo, Sheng-Chu, Wu, Tian-Shung, Lednicer, Dan, Lin, Chii M, Hamel, Ernest, Lee, Kuo-Hsiung

“…As part of our continuing search for potential anticancer drug candidates in the 2-phenyl-4-quinolone series, we have synthesized a series of…”
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Synthesis and Biological Evaluation of 2-Acyl Analogues of Paclitaxel (Taxol) by Kingston, David G. I, Chaudhary, Ashok G, Chordia, Mahendra D, Gharpure, Milind, Gunatilaka, A. A. Leslie, Higgs, Paul I, Rimoldi, John M, Samala, Lakshman, Jagtap, Prakash G, Giannakakou, Paraskevi, Jiang, Yuan Q, Lin, Chii M, Hamel, Ernest, Long, Byron H, Fairchild, Craig R, Johnston, Kathy A

“…The anticancer drug paclitaxel (Taxol) has been converted to a large number of 2-debenzoyl-2-aroyl derivatives by three different methods. The bioactivities of…”
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Unexpectedly Facile Hydrolysis of the 2-Benzoate Group of Taxol and Syntheses of Analogs with Increased Activities by Chaudhary, Ashok G, Gharpure, Milind M, Rimoldi, John M, Chordia, Mahendra D, Kingston, David G. I, Grover, Surinder, Lin, Chii M, Hamel, Ernest, Gunatilaka, A. A. Leslie

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Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles by Hamel, Ernest, Lin, Chii M

“…A new method for separating microtubule-associated proteins (MAPs) and tubulin, appropriate for relatively large-scale preparations, was developed. Most of the…”
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Synthesis and evaluation of a series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization by Cushman, Mark, He, Hu Ming, Lin, Chii M, Hamel, Ernest

“…Although certain substituted cis-stilbenes have displayed potent tubulin polymerization inhibitory activity and significant cytotoxicities in cancer cell…”
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