Search Results - "Lin, Charles Y"

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes by Whyte, Warren A., Orlando, David A., Hnisz, Denes, Abraham, Brian J., Lin, Charles Y., Kagey, Michael H., Rahl, Peter B., Lee, Tong Ihn, Young, Richard A.

“…Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent…”
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Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers by Lovén, Jakob, Hoke, Heather A., Lin, Charles Y., Lau, Ashley, Orlando, David A., Vakoc, Christopher R., Bradner, James E., Lee, Tong Ihn, Young, Richard A.

“…Chromatin regulators have become attractive targets for cancer therapy, but it is unclear why inhibition of these ubiquitous regulators should have…”
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Transcriptional Amplification in Tumor Cells with Elevated c-Myc by Lin, Charles Y., Lovén, Jakob, Rahl, Peter B., Paranal, Ronald M., Burge, Christopher B., Bradner, James E., Lee, Tong Ihn, Young, Richard A.

“…Elevated expression of the c-Myc transcription factor occurs frequently in human cancers and is associated with tumor aggression and poor clinical outcome. The…”
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Convergence of Developmental and Oncogenic Signaling Pathways at Transcriptional Super-Enhancers by Hnisz, Denes, Schuijers, Jurian, Lin, Charles Y., Weintraub, Abraham S., Abraham, Brian J., Lee, Tong Ihn, Bradner, James E., Young, Richard A.

“…Super-enhancers and stretch enhancers (SEs) drive expression of genes that play prominent roles in normal and disease cells, but the functional importance of…”
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Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma by Chapuy, Bjoern, McKeown, Michael R., Lin, Charles Y., Monti, Stefano, Roemer, Margaretha G.M., Qi, Jun, Rahl, Peter B., Sun, Heather H., Yeda, Kelly T., Doench, John G., Reichert, Elaine, Kung, Andrew L., Rodig, Scott J., Young, Richard A., Shipp, Margaret A., Bradner, James E.

“…Diffuse large B cell lymphoma (DLBCL) is a biologically heterogeneous and clinically aggressive disease. Here, we explore the role of bromodomain and…”
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Revisiting Global Gene Expression Analysis by Lovén, Jakob, Orlando, David A., Sigova, Alla A., Lin, Charles Y., Rahl, Peter B., Burge, Christopher B., Levens, David L., Lee, Tong Ihn, Young, Richard A.

“…Gene expression analysis is a widely used and powerful method for investigating the transcriptional behavior of biological systems, for classifying cell states…”
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BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure by Anand, Priti, Brown, Jonathan D., Lin, Charles Y., Qi, Jun, Zhang, Rongli, Artero, Pedro Calderon, Alaiti, M. Amer, Bullard, Jace, Alazem, Kareem, Margulies, Kenneth B., Cappola, Thomas P., Lemieux, Madeleine, Plutzky, Jorge, Bradner, James E., Haldar, Saptarsi M.

“…Heart failure (HF) is driven by the interplay between regulatory transcription factors and dynamic alterations in chromatin structure. Pathologic gene…”
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NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis by Brown, Jonathan D., Lin, Charles Y., Duan, Qiong, Griffin, Gabriel, Federation, Alexander J., Paranal, Ronald M., Bair, Steven, Newton, Gail, Lichtman, Andrew H., Kung, Andrew L., Yang, Tianlun, Wang, Hong, Luscinskas, Francis W., Croce, Kevin J., Bradner, James E., Plutzky, Jorge

“…Proinflammatory stimuli elicit rapid transcriptional responses via transduced signals to master regulatory transcription factors. To explore the role of…”
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Taming of the beast: shaping Myc-dependent amplification by Wolf, Elmar, Lin, Charles Y, Eilers, Martin, Levens, David L

“…Highlights • Myc is a general regulator that binds to established euchromatin in the cell. • Myc acts as a nonlinear amplifier of transcription. • Miz1 and…”
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Mutant NPM1 Maintains the Leukemic State through HOX Expression by Brunetti, Lorenzo, Gundry, Michael C., Sorcini, Daniele, Guzman, Anna G., Huang, Yung-Hsin, Ramabadran, Raghav, Gionfriddo, Ilaria, Mezzasoma, Federica, Milano, Francesca, Nabet, Behnam, Buckley, Dennis L., Kornblau, Steven M., Lin, Charles Y., Sportoletti, Paolo, Martelli, Maria Paola, Falini, Brunangelo, Goodell, Margaret A.

“…NPM1 is the most frequently mutated gene in cytogenetically normal acute myeloid leukemia (AML). In AML cells, NPM1 mutations result in abnormal cytoplasmic…”
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BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment by Winter, Georg E., Mayer, Andreas, Buckley, Dennis L., Erb, Michael A., Roderick, Justine E., Vittori, Sarah, Reyes, Jaime M., di Iulio, Julia, Souza, Amanda, Ott, Christopher J., Roberts, Justin M., Zeid, Rhamy, Scott, Thomas G., Paulk, Joshiawa, Lachance, Kate, Olson, Calla M., Dastjerdi, Shiva, Bauer, Sophie, Lin, Charles Y., Gray, Nathanael S., Kelliher, Michelle A., Churchman, L. Stirling, Bradner, James E.

“…Processive elongation of RNA Polymerase II from a proximal promoter paused state is a rate-limiting event in human gene control. A small number of regulatory…”
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Models of human core transcriptional regulatory circuitries by Saint-André, Violaine, Federation, Alexander J, Lin, Charles Y, Abraham, Brian J, Reddy, Jessica, Lee, Tong Ihn, Bradner, James E, Young, Richard A

“…A small set of core transcription factors (TFs) dominates control of the gene expression program in embryonic stem cells and other well-studied cellular…”
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HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling by Travers, Joshua G., Wennersten, Sara A., Peña, Brisa, Bagchi, Rushita A., Smith, Harrison E., Hirsch, Rachel A., Vanderlinden, Lauren A., Lin, Ying-Hsi, Dobrinskikh, Evgenia, Demos-Davies, Kimberly M., Cavasin, Maria A., Mestroni, Luisa, Steinkühler, Christian, Lin, Charles Y., Houser, Steven R., Woulfe, Kathleen C., Lam, Maggie P.Y., McKinsey, Timothy A.

“…Diastolic dysfunction (DD) is associated with the development of heart failure and contributes to the pathogenesis of other cardiac maladies, including atrial…”
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Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype by Olson, Calla M, Liang, Yanke, Leggett, Alan, Park, Woojun D, Li, Lianbo, Mills, Caitlin E, Elsarrag, Selma Z, Ficarro, Scott B, Zhang, Tinghu, Düster, Robert, Geyer, Matthias, Sim, Taebo, Marto, Jarrod A, Sorger, Peter K, Westover, Ken D, Lin, Charles Y, Kwiatkowski, Nicholas, Gray, Nathanael S

“…Cyclin-dependent kinase 7 (CDK7) regulates both cell cycle and transcription, but its precise role remains elusive. We previously described THZ1, a CDK7…”
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Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer by Heyn, Holger, Vidal, Enrique, Ferreira, Humberto J, Vizoso, Miguel, Sayols, Sergi, Gomez, Antonio, Moran, Sebastian, Boque-Sastre, Raquel, Guil, Sonia, Martinez-Cardus, Anna, Lin, Charles Y, Royo, Romina, Sanchez-Mut, Jose V, Martinez, Ramon, Gut, Marta, Torrents, David, Orozco, Modesto, Gut, Ivo, Young, Richard A, Esteller, Manel

“…One of the hallmarks of cancer is the disruption of gene expression patterns. Many molecular lesions contribute to this phenotype, and the importance of…”
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PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer by Spangle, Jennifer M., Dreijerink, Koen M., Groner, Anna C., Cheng, Hailing, Ohlson, Carolynn E., Reyes, Jaime, Lin, Charles Y., Bradner, James, Zhao, Jean J., Roberts, Thomas M., Brown, Myles

“…Post-translational histone H3 modifications regulate transcriptional competence. The mechanisms by which the epigenome is regulated in response to oncogenic…”
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Discovery of a selective inhibitor of doublecortin like kinase 1 by Ferguson, Fleur M., Nabet, Behnam, Raghavan, Srivatsan, Liu, Yan, Leggett, Alan L., Kuljanin, Miljan, Kalekar, Radha L., Yang, Annan, He, Shuning, Wang, Jinhua, Ng, Raymond W. S., Sulahian, Rita, Li, Lianbo, Poulin, Emily J., Huang, Ling, Koren, Jost, Dieguez-Martinez, Nora, Espinosa, Sergio, Zeng, Zhiyang, Corona, Cesear R., Vasta, James D., Ohi, Ryoma, Sim, Taebo, Kim, Nam Doo, Harshbarger, Wayne, Lizcano, Jose M., Robers, Matthew B., Muthaswamy, Senthil, Lin, Charles Y., Look, A. Thomas, Haigis, Kevin M., Mancias, Joseph D., Wolpin, Brian M., Aguirre, Andrew J., Hahn, William C., Westover, Kenneth D., Gray, Nathanael S.

“…Doublecortin like kinase 1 (DCLK1) is an understudied kinase that is upregulated in a wide range of cancers, including pancreatic ductal adenocarcinoma (PDAC)…”
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Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13 by Zeng, Mei, Kwiatkowski, Nicholas P, Zhang, Tinghu, Nabet, Behnam, Xu, Mousheng, Liang, Yanke, Quan, Chunshan, Wang, Jinhua, Hao, Mingfeng, Palakurthi, Sangeetha, Zhou, Shan, Zeng, Qing, Kirschmeier, Paul T, Meghani, Khyati, Leggett, Alan L, Qi, Jun, Shapiro, Geoffrey I, Liu, Joyce F, Matulonis, Ursula A, Lin, Charles Y, Konstantinopoulos, Panagiotis A, Gray, Nathanael S

“…High-grade serous ovarian cancer is characterized by extensive copy number alterations, among which the amplification of oncogene occurs in nearly half of…”
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PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma by Bleu, Melusine, Gaulis, Swann, Lopes, Rui, Sprouffske, Kathleen, Apfel, Verena, Holwerda, Sjoerd, Pregnolato, Marco, Yildiz, Umut, Cordoʹ, Valentina, Dost, Antonella F. M., Knehr, Judith, Carbone, Walter, Lohmann, Felix, Lin, Charles Y., Bradner, James E., Kauffmann, Audrey, Tordella, Luca, Roma, Guglielmo, Galli, Giorgio G.

“…Transcription factor networks shape the gene expression programs responsible for normal cell identity and pathogenic state. Using Core Regulatory Circuitry…”
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BET bromodomain proteins regulate enhancer function during adipogenesis by Brown, Jonathan D., Feldman, Zachary B., Doherty, Sean P., Reyes, Jaime M., Rahl, Peter B., Lin, Charles Y., Sheng, Quanhu, Duan, Qiong, Federation, Alexander J., Kung, Andrew L., Haldar, Saptarsi M., Young, Richard A., Plutzky, Jorge, Bradner, James E.

“…Developmental transitions are guided by master regulatory transcription factors. During adipogenesis, a transcriptional cascade culminates in the expression of…”
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