Search Results - "Lin, Caorui"

Glycine Enhances Satellite Cell Proliferation, Cell Transplantation, and Oligonucleotide Efficacy in Dystrophic Muscle by Lin, Caorui, Han, Gang, Ning, Hanhan, Song, Jun, Ran, Ning, Yi, Xianfu, Seow, Yiqi, Yin, HaiFang

“…The need to distribute therapy evenly systemically throughout the large muscle volume within the body makes Duchenne muscular dystrophy (DMD) therapy a…”
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Generalizable anchor aptamer strategy for loading nucleic acid therapeutics on exosomes by Han, Gang, Zhang, Yao, Zhong, Li, Wang, Biaobiao, Qiu, Shuai, Song, Jun, Lin, Caorui, Zou, Fangdi, Wu, Jingqiao, Yu, Huanan, Liang, Chao, Wen, Ke, Seow, Yiqi, Yin, HaiFang

“…Clinical deployment of oligonucleotides requires delivery technologies that improve stability, target tissue accumulation and cellular internalization…”
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Characterization of BCP/PreC/C region quasispecies in treatment-naive patients with different phases of HBV infection using next-generation sequencing by Zhu, Chenggong, Tang, Minjie, Fu, Ya, Xun, Zhen, Lin, Caorui, Wu, Songhang, Chen, Tianbin, Zeng, Yongbin, Yang, Bin, Ou, Qishui, Liu, Can

“…To analysis of quasispecies (QS) changes and high-frequency mutations in the BCP/PreC/C region of patients at different phases of hepatitis B virus (HBV)…”
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Adenosine Triphosphate in Serum as a Promising Biomarker for Differential Diagnosis of Hepatitis B Disease Progression by Lin, Caorui, Huang, Ying, Luo, Linjie, Fang, Fengling, Zhang, Jiawei, Xun, Zhen, Fu, Ya, Shang, Hongyan, Liu, Can, Ou, Qishui

“…The need to be diagnosed with liver biopsy makes the clinical progression of chronic HBV infection diagnosis a challenge. Existing HBV serum biochemical assays…”
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Autologous exosome facilitates load and target delivery of bioactive peptides to repair spinal cord injury by Ran, Ning, Li, Wenxiang, Zhang, Renjie, Lin, Caorui, Zhang, Jianping, Wei, Zhijian, Li, Zonghao, Yuan, Zhongze, Wang, Min, Fan, Baoyou, Shen, Wenyuan, Li, Xueying, Zhou, Hengxing, Yao, Xue, Kong, Xiaohong, Feng, Shiqing

“…Spinal cord injury (SCI) causes motor, sensory and automatic impairment due to rarely axon regeneration. Developing effective treatment for SCI in the clinic…”
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Long-Term Morpholino Oligomers in Hexose Elicit Long-Lasting Therapeutic Improvements in mdx Mice by Han, Gang, Lin, Caorui, Ning, Hanhan, Gao, Xianjun, Yin, HaiFang

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Multi-omics reveals deoxycholic acid modulates bile acid metabolism via the gut microbiota to antagonize carbon tetrachloride-induced chronic liver injury by Zhang, Li, Zheng, Zhiyi, Huang, Huanhuan, Fu, Ya, Chen, Tianbin, Liu, Can, Yi, Qiang, Lin, Caorui, Zeng, Yongjun, Ou, Qishui, Zeng, Yongbin

“…Deoxycholic acid (DCA) serves essential functions in both physiological and pathological liver processes; nevertheless, the relationship among DCA, gut…”
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MOTS‐c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice by Ran, Ning, Lin, Caorui, Leng, Ling, Han, Gang, Geng, Mengyuan, Wu, Yingjie, Bittner, Scott, Moulton, Hong M, Yin, HaiFang

“…Antisense oligonucleotide (AO)‐mediated exon‐skipping therapies show promise in Duchenne muscular dystrophy (DMD), a devastating muscular disease caused by…”
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Long-Term Morpholino Oligomers in Hexose Elicits Long-Lasting Therapeutic Improvements in mdx Mice by Han, Gang, Lin, Caorui, Ning, Hanhan, Gao, Xianjun, Yin, HaiFang

“…Approval of antisense oligonucleotide eteplirsen highlights the promise of exon-skipping therapeutics for Duchenne muscular dystrophy patients. However, the…”
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Nomogram Model for Prediction of SARS-CoV-2 Breakthrough Infection in Fujian: A Case–Control Real-World Study by Chen, Tianbin, Zeng, Yongbin, Yang, Di, Ye, Wenjing, Zhang, Jiawei, Lin, Caorui, Huang, Yihao, Ye, Yucheng, Li, Jianwen, Ou, Qishui, Li, Jinming, Liu, Can

“…SARS-CoV-2 breakthrough infections have been reported because of the reduced efficacy of vaccines against the emerging variants globally. However, an accurate…”
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A novel TRIM22 gene polymorphism promotes the response to PegIFNα therapy through cytokine-cytokine receptor interaction signaling pathway in chronic hepatitis B by Wang, Long, Lin, Ni, Zhang, Yanfang, Guo, Shaoying, Liu, Can, Lin, Caorui, Zeng, Yongbin, Wu, Wennan, Guo, Jianhui, Zhu, Chenggong, Zhan, Fuguo, Ou, Qishui, Xun, Zhen

“…Pegylated interferon alfa (PegIFNα) has limited efficacy in the treatment of chronic hepatitis B (CHB). Although many biomarkers related to hepatitis B virus…”
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Hexose Potentiates Peptide-Conjugated Morpholino Oligomer Efficacy in Cardiac Muscles of Dystrophic Mice in an Age-Dependent Manner by Han, Gang, Gu, Ben, Lin, Caorui, Ning, Hanhan, Song, Jun, Gao, Xianjun, Moulton, Hong M., Yin, HaiFang

“…Insufficient delivery of oligonucleotides to muscle and heart remains a barrier for clinical implementation of antisense oligonucleotide (AO)-mediated…”
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Proteomic characterization of the natural history of chronic HBV infection revealed by tandem mass tag-based quantitative proteomics approach by Xun, Zhen, Yao, Xiaobao, Zhu, Chenggong, Ye, Yuchen, Wu, Songhang, Chen, Tianbin, Zeng, Yongbin, Lin, Caorui, Yang, Bin, Ou, Qishui, Liu, Can

“…Currently, determining when to start antiviral therapy in patients with chronic HBV infection is a controversial issue. One crucial reason is that biomarkers…”
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Fructose Promotes Uptake and Activity of Oligonucleotides with Different Chemistries in a Context-Dependent Manner in mdx Mice by Cao, Limin, Han, Gang, Lin, Caorui, Gu, Ben, Gao, Xianjun, Moulton, Hong M., Seow, Yiqi, Yin, HaiFang

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Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice by Cao, Limin, Han, Gang, Lin, Caorui, Gu, Ben, Gao, Xianjun, Moulton, Hong M, Seow, Yiqi, Yin, HaiFang

“…Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne…”
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Emerging role of mitochondria in response to HBV infection by Lin, Caorui, Ou, Qishui

“…Hepatitis B is a major global health problem that potentially life‐threatening liver infection caused by the hepatitis B virus (HBV), which can lead to death…”
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Effects of exosome-mediated delivery of myostatin propeptide on functional recovery of mdx mice by Ran, Ning, Gao, Xianjun, Dong, Xue, Li, Junjin, Lin, Caorui, Geng, Mengyuan, Yin, HaiFang

“…Duchenne muscular dystrophy (DMD) is a devastating disorder caused by loss of functional dystrophin protein, resulting in muscle wasting. Enhancing muscle…”
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Upregulation of Wilms’ Tumor 1 in epicardial cells increases cardiac fibrosis in dystrophic mice by Guo, Zhenglong, Geng, Mengyuan, Huang, Yuting, Han, Gang, Jing, Renwei, Lin, Caorui, Zhang, Xiaoning, Zhang, Miaomiao, Fan, Guanwei, Wang, Feng, Yin, HaiFang

“…Cardiomyopathy is a primary cause of mortality in Duchenne muscular dystrophy (DMD) patients. Mechanistic understanding of cardiac fibrosis holds the key to…”
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Detection of serum large and middle hepatitis B virus surface proteins: A novel potential diagnostic and prognostic biomarker for chronic hepatitis B by Zeng, Yongbin, Zhu, Chenggong, Huang, Er, Xun, Zhen, Zhang, Yanfang, Chen, Tianbin, Lin, Caorui, Fu, Ya, Wu, Songhang, Yang, Bin, Ou, Qishui, Liu, Can

“…•Clarified the dynamic patterns of envelope proteins across different phases of HBV infection and distinct liver diseases.•Demonstrated that LHB and MHB serve…”
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Cardio‐respiratory and phenotypic rescue of dystrophin/utrophin‐deficient mice by combination therapy by Lin, Caorui, Han, Gang, Jia, Lulu, Zhao, Yiwen, Song, Jun, Ran, Ning, Yokota, Toshifumi, Seow, Yiqi, Yin, HaiFang

“…Duchenne muscular dystrophy (DMD) is a systemic progressive muscular disease caused by frame‐disrupting mutations in the DMD gene. Although exon‐skipping…”
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