Search Results - "Lin, Brian L."

Transcriptomic entropy benchmarks stem cell-derived cardiomyocyte maturation against endogenous tissue at single cell level by Kannan, Suraj, Farid, Michael, Lin, Brian L, Miyamoto, Matthew, Kwon, Chulan

“…The immaturity of pluripotent stem cell (PSC)-derived tissues has emerged as a universal problem for their biomedical applications. While efforts have been…”
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Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophy by Boyer, Justin G., Huo, Jiuzhou, Han, Sarah, Havens, Julian R., Prasad, Vikram, Lin, Brian L., Kass, David A., Song, Taejeong, Sadayappan, Sakthivel, Khairallah, Ramzi J., Ward, Christopher W., Molkentin, Jeffery D.

“…Skeletal muscle can repair and regenerate due to resident stem cells known as satellite cells. The muscular dystrophies are progressive muscle wasting diseases…”
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Pharmacological TRPC6 inhibition improves survival and muscle function in mice with Duchenne muscular dystrophy by Lin, Brian L, Shin, Joseph Y, Jeffreys, William Pd, Wang, Nadan, Lukban, Clarisse A, Moorer, Megan C, Velarde, Esteban, Hanselman, Olivia A, Kwon, Seoyoung, Kannan, Suraj, Riddle, Ryan C, Ward, Christopher W, Pullen, Steven S, Filareto, Antonio, Kass, David A

“…Gene mutations causing loss of dystrophin result in the severe muscle disease known as Duchenne muscular dystrophy (DMD). Despite efforts at genetic repair,…”
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HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics by Chan, Xin Yi, Volkova, Eugenia, Eoh, Joon, Black, Rebecca, Fang, Lilly, Gorashi, Rayyan, Song, Jihyun, Wang, Jing, Elliott, Morgan B., Barreto-Ortiz, Sebastian F., Chen, James, Lin, Brian L., Santhanam, Lakshmi, Cheng, Linzhao, Lee, Frank S., Prchal, Josef T., Gerecht, Sharon

“…Heterozygous gain-of-function (GOF) mutations of hypoxia-inducible factor 2α (HIF2A), a key hypoxia-sensing regulator, are associated with erythrocytosis,…”
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Single cell RNA-seq analysis of the flexor digitorum brevis mouse myofibers by Verma, Rohan X, Kannan, Suraj, Lin, Brian L, Fomchenko, Katherine M, Nieuwenhuis, Tim O, Patil, Arun H, Lukban, Clarisse, Yang, Xiaoping, Fox-Talbot, Karen, McCall, Matthew N, Kwon, Chulan, Kass, David A, Rosenberg, Avi Z, Halushka, Marc K

“…Skeletal muscle myofibers can be separated into functionally distinct cell types that differ in gene and protein expression. Current single cell expression…”
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PKG1α Cysteine-42 Redox State Controls mTORC1 Activation in Pathological Cardiac Hypertrophy by Oeing, Christian U., Nakamura, Taishi, Pan, Shi, Mishra, Sumita, Dunkerly-Eyring, Brittany L., Kokkonen-Simon, Kristen M., Lin, Brian L., Chen, Anna, Zhu, Guangshuo, Bedja, Djahida, Lee, Dong Ik, Kass, David A., Ranek, Mark J.

“…RATIONALE:Stimulated PKG1α (protein kinase G-1α) phosphorylates TSC2 (tuberous sclerosis complex 2) at serine 1365, potently suppressing mTORC1 (mechanistic…”
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Cadmium exposure induces a sex-dependent decline in left ventricular cardiac function by Fitch, Michael L., Kabir, Raihan, Ebenebe, Obialunanma V., Taube, Nicole, Garbus, Haley, Sinha, Prithvi, Wang, Nadan, Mishra, Sumita, Lin, Brian L., Muller, Grace K., Kohr, Mark J.

“…Cadmium exposure is a worldwide problem that has been linked to the development of cardiovascular disease. This study aimed to elucidate mechanistic details of…”
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Pulmonary artery pulsatility index predicts right ventricular myofilament dysfunction in advanced human heart failure by Aslam, M. Imran, Jani, Vivek, Lin, Brian L., Dunkerly‐Eyring, Brittany, Livingston, Carissa E., Ramachandran, Abhinay, Ranek, Mark J., Bedi, Kenneth C., Margulies, Kenneth B., Kass, David A., Hsu, Steven

“…Among clinical indices of right heart failure in advanced heart failure, the pulmonary artery pulsatility index best reflects underlying defects in right…”
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Spatial Proteomic Approach to Characterize Skeletal Muscle Myofibers by Fomchenko, Katherine M, Walsh, Elise M, Yang, Xiaoping, Verma, Rohan X, Lin, Brian L, Nieuwenhuis, Tim O, Patil, Arun H, Fox-Talbot, Karen, McCall, Matthew N, Kass, David A, Rosenberg, Avi Z, Halushka, Marc K

“…Skeletal muscle myofibers have differential protein expression resulting in functionally distinct slow- and fast-twitch types. While certain protein classes…”
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An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor by Reyes Gaido, Oscar E, Pavlaki, Nikoleta, Granger, Jonathan M, Mesubi, Olurotimi O, Liu, Bian, Lin, Brian L, Long, Alan, Walker, David, Mayourian, Joshua, Schole, Kate L, Terrillion, Chantelle E, Nkashama, Lubika J, Hulsurkar, Mohit M, Dorn, Lauren E, Ferrero, Kimberly M, Huganir, Richard L, Müller, Frank U, Wehrens, Xander H T, Liu, Jun O, Luczak, Elizabeth D, Bezzerides, Vassilios J, Anderson, Mark E

“…Ca /calmodulin-dependent protein kinase II (CaMKII) hyperactivity causes cardiac arrhythmias, a major source of morbidity and mortality worldwide. Despite…”
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Potential limitations of microdystrophin gene therapy for Duchenne muscular dystrophy by Hart, Cora C, Lee, Young Il, Xie, Jun, Gao, Guangping, Lin, Brian L, Hammers, David W, Sweeney, H Lee

“…Clinical trials delivering high doses of adeno-associated viruses (AAVs) expressing truncated dystrophin molecules (microdystrophins) are underway for Duchenne…”
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Abstract P1033: A Simple 2-D Assay For Measuring Contraction And Calcium Kinetics In Engineered Human Cardiomyocytes To Model Duchenne Muscular Dystrophy by Lin, Brian L, Jeffreys, William, Wu, Alex, Kass, David A

“…Duchenne muscular dystrophy (DMD) is caused by the loss of the dystrophin protein, resulting in progressive muscle wasting, loss of ambulation, and early…”
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Skeletal Muscle Deficiencies in Homozygous Fast-Skeletal Myosin Binding Protein-C Mutant Mice by Lin, Brian L., Govindan, Suresh, Sadayappan, Sakthivel

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Abstract 13500: An Improved Reporter Identifies Ruxolitinib as a Potent and Cardioprotective CaMKII Inhibitor by Reyes Gaido, Oscar E, Pavlaki, Nikoleta, Granger, Jonathan, Mesubi, Olurotimi O, Liu, Bian, Lin, Brian L, Long, Alan, Walker, David, Mayourian, Joshua, Schole, Kate L, Terrillion, Chantelle E, Nkashama, Lubika J, Hulsurkar, Mohit M, Dorn, Lauren E, Ferrero, Kimberly M, Huganir, Richard L, Muller, Frank U, Wehrens, Xander H, Liu, Jun O, Luczak, Elizabeth, Bezzerides, Vassilios J, Anderson, Mark E

“…Abstract only Background: Ca 2+ /Calmodulin-dependent protein kinase II (CaMKII) hyperactivity is an established driver of cardiac arrhythmias. Despite proven…”
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Potential limitations of micro-dystrophin gene therapy for Duchenne muscular dystrophy by Hart, Cora C., Lee, Young il, Xie, Jun, Gao, Guangping, Lin, Brian L., Hammers, David W., Sweeney, H. Lee

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Abstract 253: Pharmacological and Genetic Inhibition of Transient Receptor Potential Canonical 6 (TRPC6) as a Novel Treatment for Heart Failure and Duchenne Muscular Dystrophy (DMD) Pharmacological and Genetic Inhibition of Transient Receptor Potential Canonical 6 (TRPC6) as a Novel Treatment for Heart Failure and Duchenne Muscular Dystrophy (DMD) by Lin, Brian L, Mishra, Sumita, Muller, Grace K, Bedja, Djahida, Zhu, Guangshuo, Yang, Jinying, Anderson, Mark E, Pullen, Steve S, Kass, David A

“…Abstract only Intro: Duchenne muscular dystrophy (DMD) patients suffer from spinal deformities (scoliosis and kyphosis) and die prematurely in their thirties,…”
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CaMKII Regulates TRPC6 Mediated Stress Stimulated Contractility in Muscular Dystrophy by Lin, Brian L., Mishra, Sumita, Kim, Grace E., Kanann, Suraj, Yang, Jinying, Kwon, Chulan, Anderson, Mark, Pullen, Steven S., Kass, David A.

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Chronic Atrial and Ventricular Pacing in the Mouse: Application to Model Cardiac Dyssynchrony and Resynchronization in Heart Failure by Ståhlberg, Marcus, Nakagawa, Ryo, Bedja, Djahida, Zhu, Guangshuo, Lin, Brian L., Saberi, Amir, Lee, Dong I., Kass, David A.

“…Background: The mouse is the most widely used mammal in experimental biology. Although many clinically relevant in vivo cardiac stressors are used, one that…”
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Chronic Atrial and Ventricular Pacing in the Mouse by Ståhlberg, Marcus, Nakagawa, Ryo, Bedja, Djahida, Zhu, Guangshuo, Lin, Brian L, Saberi, Amir, Lee, Dong I, Kass, David A

“…The mouse is the most widely used mammal in experimental biology. Although many clinically relevant in vivo cardiac stressors are used, one that has eluded…”
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Electrochemical Corrosion Behavior of Arc Sprayed Zn and Zn15Al Coatings in Simulated Salina Soil and Neutral Meadow Soil Solutions by Lin, Bilan, Lu, Xinying, Li, Long

“…Arc sprayed Zn and Zn15Al coatings were chosen to protect the metal ends of prestressed high-strength concrete （PHC） pipe piles against corrosion of salina…”
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