Search Results - "Lin, Anning"

Activation of the JNK signaling pathway: Breaking the brake on apoptosis by Lin, Anning

“…The JNK signaling pathway is involved in regulation of many cellular events, including growth control, transformation and programmed cell death (apoptosis)…”
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Role of JNK activation in apoptosis： A double-edged sword by Liu, Jing, Lin, Anning

“…JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF-κB activation, prolonged JNK activation…”
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The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation by Zhang, Wenjie, Zhangyuan, Guangyan, Wang, Fei, Jin, Kangpeng, Shen, Haiyuan, Zhang, Liansheng, Yuan, Xiang, Wang, Jincheng, Zhang, Haitian, Yu, Weiwei, Huang, Ruyi, Xu, Xiaoliang, Yin, Yin, Zhong, Guisheng, Lin, Anning, Sun, Beicheng

“…Chronic inflammation plays a central role in hepatocellular carcinoma (HCC), but the contribution of hepatocytes to tumor-associated inflammation is not clear…”
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Akt-mediated platelet apoptosis and its therapeutic implications in immune thrombocytopenia by Chen, Mengxing, Yan, Rong, Zhou, Kangxi, Li, Xiaodong, Zhang, Yang, Liu, Chunliang, Jiang, Mengxiao, Ye, Honglei, Meng, Xingjun, Pang, Ningbo, Zhao, Lili, Liu, Jun, Xiao, Weiling, Hu, Renping, Cui, Qingya, Zhong, Wei, Zhao, Yunxiao, Zhu, Mingqing, Lin, Anning, Ruan, Changgeng, Dai, Kesheng

“…Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet count which can cause fatal hemorrhage. ITP patients with antiplatelet…”
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Multi-Omics Analysis in β-Thalassemia Using an HBB Gene-Knockout Human Erythroid Progenitor Cell Model by Zhou, Guoqiang, Zhang, Haokun, Lin, Anning, Wu, Zhen, Li, Ting, Zhang, Xumin, Chen, Hongyan, Lu, Daru

“…β-thalassemia is a hematologic disease that may be associated with significant morbidity and mortality. Increased expression of can ameliorate the severity of…”
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Assessment of neurodegeneration and neuronal loss in aged 5XFAD mice by Zhang, Liansheng, Li, Jie, Lin, Anning

“…Neuronal loss resulting from progressive neurodegeneration is a major pathological feature of Alzheimer’s disease (AD). Here, we present a protocol to detect…”
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Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching by Zhao, Yu, Lin, Yuting, Zhang, Honghong, Mañas, Adriana, Tang, Wenwen, Zhang, Yuzhu, Wu, Dianqing, Lin, Anning, Xiang, Jialing

“…The serine-threonine kinase Akt is a key regulator of cell proliferation and survival, glucose metabolism, cell mobility, and tumorigenesis. Activation of Akt…”
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c-Jun N-Terminal Protein Kinase 1 (JNK1), but Not JNK2, Is Essential for Tumor Necrosis Factor Alpha-Induced c-Jun Kinase Activation and Apoptosis by Liu, Jing, Minemoto, Yuzuru, Lin, Anning

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK by Sheng, Xiangpeng, You, Qing, Zhu, Hongnian, Chang, ZeNan, Li, Qingrun, Wang, Haifeng, Wang, Chen, Wang, Hongyan, Hui, Lijian, Du, Chongtao, Xie, Xiaoduo, Zeng, Rong, Lin, Anning, Shi, Dongfang, Ruan, Kangcheng, Yan, Jinghua, Gao, George Fu, Shao, Feng, Hu, Ronggui

“…As a major diarrheagenic human pathogen, enterohemorrhagic Escherichia coli (EHEC) produce attaching and effacing (A/E) lesions, characterized by the formation…”
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BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages by Li, Jie, Zhang, Liansheng, Zheng, Yongwei, Shao, Rui, Liang, Qianqian, Yu, Weida, Wang, Hongyan, Zou, Weiguo, Wang, Demin, Xiang, Jialing, Lin, Anning

“…The resistance of synovial sublining macrophages to apoptosis has a crucial role in joint inflammation and destruction in rheumatoid arthritis (RA). However,…”
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Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1 by Sheng, Nengyin, Xie, Zhihui, Wang, Chen, Bai, Ge, Zhang, Kejing, Zhu, Qingqing, Song, Jianguo, Guillemot, Francois, Chen, Ye-Guang, Lin, Anning, Jing, Naihe, Cobb, Melanie H.

“…The proper function of the bone morphogenic protein (BMP) pathway during embryonic development and organ maintenance requires its communication with other…”
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Selective Inactivation of c-Jun NH2-Terminal Kinase in Adipose Tissue Protects Against Diet-Induced Obesity and Improves Insulin Sensitivity in Both Liver and Skeletal Muscle in Mice by XINMEI ZHANG, AIMIN XU, CHUNG, Sookja K, CRESSER, Justin H. B, SWEENEY, Gary, WONG, Rachel L. C, ANNING LIN, LAM, Karen S. L

“…Obesity is associated with increased activation of the c-Jun NH(2)-terminal kinase (JNK) in several metabolic organs, including adipose tissue, liver, and…”
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BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology by Zhang, Liansheng, Qian, Yun, Li, Jie, Zhou, Xuan, Xu, He, Yan, Jie, Xiang, Jialing, Yuan, Xiang, Sun, Beicheng, Sisodia, Sangram S., Jiang, Yong-Hui, Cao, Xiaohua, Jing, Naihe, Lin, Anning

“…Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease. However, the underlying molecular mechanism is incompletely understood. Here…”
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Inhibition of JNK activation through NF- κ B target genes by Lin, Anning, Tang, Guilin, Minemoto, Yuzuru, Dibling, Benjamin, Purcell, Nicole H, Li, Zhiwei, Karin, Michael

“…The proinflammatory cytokine tumour necrosis factor-α (TNF-α) regulates immune responses, inflammation and programmed cell death (apoptosis). The ultimate fate…”
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Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis by Depaolo, R William, Tang, Fangming, Kim, Inyoung, Han, Mei, Levin, Nadine, Ciletti, Nancy, Lin, Anning, Anderson, Debra, Schneewind, Olaf, Jabri, Bana

“…Educating dendritic cells (DC) to become tolerogenic DC, which promote regulatory IL-10 immune responses, represents an effective immune evasion strategy for…”
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Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α–induced JNK activation and inflammation by Liu, Jing, Yan, Jie, Jiang, Shan, Wen, Jing, Chen, Long, Zhao, Yingming, Lin, Anning

“…The transcription factor zinc-finger protein Miz1 represses TNF-α–induced JNK activation and the repression is relieved upon TNF-α stimulation. However, the…”
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JNK Suppresses Apoptosis via Phosphorylation of the Proapoptotic Bcl-2 Family Protein BAD by Yu, Chenfei, Minemoto, Yuzuru, Zhang, Jiyan, Liu, Jing, Tang, Fangming, Bui, Truc N., Xiang, Jialing, Lin, Anning

“…JNK has been suggested to be proapoptotic, antiapoptotic, or have no role in apoptosis depending on the cell type and stimulus used. The precise mechanism of…”
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Phosphorylation of Bad at Thr-201 by JNK1 Promotes Glycolysis through Activation of Phosphofructokinase-1 by Deng, Hongbin, Yu, Fei, Chen, Jianqun, Zhao, Yingming, Xiang, Jialing, Lin, Anning

“…The mitogen-activated protein kinase JNK1 suppresses interleukin-3 withdrawal-induced cell death through phosphorylation of the BH3-only pro-apoptotic Bcl-2…”
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Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-α-induced JNK1 activation by Liu, Jing, Zhao, Yingming, Eilers, Martin, Lin, Anning

“…The proinflammatory cytokine TNF-α exerts its pleiotropic functions through activation of multiple downstream effectors, including JNK1. Yet, the underlying…”
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Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs by Minden, Audrey, Lin, Anning, Claret, François-Xavier, Abo, Arie, Karin, Michael

“…The Rho subfamily of GTPases is involved in controlof cell morphology in mammals and yeast. The mammalian Rac and Cdc42 proteins control formation of…”
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