Search Results - "Lin, Amy E."

TET2-mutant clonal hematopoiesis and risk of gout by Agrawal, Mridul, Niroula, Abhishek, Cunin, Pierre, McConkey, Marie, Shkolnik, Veronica, Kim, Peter G., Wong, Waihay J., Weeks, Lachelle D., Lin, Amy E., Miller, Peter G., Gibson, Christopher J., Sekar, Aswin, Schaefer, Inga-Marie, Neuberg, Donna, Stone, Richard M., Bick, Alexander G., Uddin, Md Mesbah, Griffin, Gabriel K., Jaiswal, Siddhartha, Natarajan, Pradeep, Nigrovic, Peter A., Rao, Deepak A., Ebert, Benjamin L.

“…Gout is a common inflammatory arthritis caused by precipitation of monosodium urate (MSU) crystals in individuals with hyperuricemia. Acute flares are…”
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IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology by Pellegrini, Marc, Calzascia, Thomas, Toe, Jesse G., Preston, Simon P., Lin, Amy E., Elford, Alisha R., Shahinian, Arda, Lang, Philipp A., Lang, Karl S., Morre, Michel, Assouline, Brigitte, Lahl, Katharina, Sparwasser, Tim, Tedder, Thomas F., Paik, Ji-hye, DePinho, Ronald A., Basta, Sameh, Ohashi, Pamela S., Mak, Tak W.

“…Understanding the factors that impede immune responses to persistent viruses is essential in designing therapies for HIV infection. Mice infected with LCMV…”
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The Clinical Challenge of Clonal Hematopoiesis, a Newly Recognized Cardiovascular Risk Factor by Sidlow, Robert, Lin, Amy E, Gupta, Dipti, Bolton, Kelly L, Steensma, David P, Levine, Ross L, Ebert, Benjamin L, Libby, Peter

“…Despite current standards of cardiovascular care, a considerable residual burden of risk remains in both primary and secondary prevention. Clonal hematopoiesis…”
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Clonal Hematopoiesis: Crossroads of Aging, Cardiovascular Disease, and Cancer: JACC Review Topic of the Week by Libby, Peter, Sidlow, Robert, Lin, Amy E, Gupta, Dipti, Jones, Lee W, Moslehi, Javid, Zeiher, Andreas, Jaiswal, Siddhartha, Schulz, Christian, Blankstein, Ron, Bolton, Kelly L, Steensma, David, Levine, Ross L, Ebert, Benjamin L

“…A novel, common, and potent cardiovascular risk factor has recently emerged: clonal hematopoiesis of indeterminate potential (CHIP). CHIP arises from somatic…”
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Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis by Kim, Peter Geon, Niroula, Abhishek, Shkolnik, Veronica, McConkey, Marie, Lin, Amy E, Słabicki, Mikołaj, Kemp, John P, Bick, Alexander, Gibson, Christopher J, Griffin, Gabriel, Sekar, Aswin, Brooks, Daniel J, Wong, Waihay J, Cohen, Drew N, Uddin, Md Mesbah, Shin, Wesley J, Pirruccello, James, Tsai, Jonathan M, Agrawal, Mridul, Kiel, Douglas P, Bouxsein, Mary L, Richards, J Brent, Evans, David M, Wein, Marc N, Charles, Julia F, Jaiswal, Siddhartha, Natarajan, Pradeep, Ebert, Benjamin L

“…Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close proximity to hematopoietic cells in the bone marrow. Recurrent…”
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Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias by Schuermans, Art, Vlasschaert, Caitlyn, Nauffal, Victor, Cho, So Mi Jemma, Uddin, Md Mesbah, Nakao, Tetsushi, Niroula, Abhishek, Klarqvist, Marcus D R, Weeks, Lachelle D, Lin, Amy E, Saadatagah, Seyedmohammad, Lannery, Kim, Wong, Megan, Hornsby, Whitney, Lubitz, Steven A, Ballantyne, Christie, Jaiswal, Siddhartha, Libby, Peter, Ebert, Benjamin L, Bick, Alexander G, Ellinor, Patrick T, Natarajan, Pradeep, Honigberg, Michael C

“…Abstract Background and Aims Clonal haematopoiesis of indeterminate potential (CHIP), the age-related expansion of blood cells with preleukemic mutations, is…”
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Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells by Sellar, Rob S, Sperling, Adam S, Słabicki, Mikołaj, Gasser, Jessica A, McConkey, Marie E, Donovan, Katherine A, Mageed, Nada, Adams, Dylan N, Zou, Charles, Miller, Peter G, Dutta, Ravi K, Boettcher, Steffen, Lin, Amy E, Sandoval, Brittany, Quevedo Barrios, Vanessa A, Kovalcik, Veronica, Koeppel, Jonas, Henderson, Elizabeth K, Fink, Emma C, Yang, Lu, Chan, Anthony, Pokharel, Sheela Pangeni, Bergstrom, Erik J, Burt, Rajan, Udeshi, Namrata D, Carr, Steven A, Fischer, Eric S, Chen, Chun-Wei, Ebert, Benjamin L

“…Targeted protein degradation is a rapidly advancing and expanding therapeutic approach. Drugs that degrade GSPT1 via the CRL4CRBN ubiquitin ligase are a new…”
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Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies by Ohashi, Pamela S, Pellegrini, Marc, Calzascia, Thomas, Elford, Alisha R, Shahinian, Arda, Lin, Amy E, Dissanayake, Dilan, Dhanji, Salim, Nguyen, Linh T, Gronski, Matthew A, Morre, Michel, Assouline, Brigitte, Lahl, Katharina, Sparwasser, Tim, Mak, Tak W

“…Interleukin-7 (IL-7) promotes immune responses and has been touted as a potential tool for improving immune targeting of tumors. Here Pellegrini et al …”
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Clonal Hematopoiesis: Confluence of Malignant and Nonmalignant Diseases by Lin, Amy E, Rauch, Philipp J, Jaiswal, Siddhartha, Ebert, Benjamin L

“…Clonal hematopoiesis of indeterminate potential (CHIP) is a state in which somatic mutations in hematopoietic stem cells lead to clonal expansion of blood…”
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Loss-of-function mutations in Dnmt3a and Tet2 lead to accelerated atherosclerosis and concordant macrophage phenotypes by Rauch, Philipp J, Gopakumar, Jayakrishnan, Silver, Alexander J, Nachun, Daniel, Ahmad, Herra, McConkey, Marie, Nakao, Tetsushi, Bosse, Marc, Rentz, Thiago, Vivanco Gonzalez, Nora, Greenwald, Noah F, McCaffrey, Erin F, Khair, Zumana, Gopakumar, Manu, Rodrigues, Kameron B, Lin, Amy E, Sinha, Eti, Fefer, Maia, Cohen, Drew N, Vromman, Amélie, Shvartz, Eugenia, Sukhova, Galina, Bendall, Sean, Angelo, Michael, Libby, Peter, Ebert, Benjamin L, Jaiswal, Siddhartha

“…Clonal hematopoiesis of indeterminate potential (CHIP) is defined by the presence of a cancer-associated somatic mutation in white blood cells in the absence…”
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Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation by Tran, Charles W, Saibil, Samuel D, Le Bihan, Thierry, Hamilton, Sara R, Lang, Karl S, You, Han, Lin, Amy E, Garza, Kristine M, Elford, Alisha R, Tai, Kelly, Parsons, Michael E, Wigmore, Kip, Vainberg, Mitchell G, Penninger, Josef M, Woodgett, James R, Mak, Tak W, Ohashi, Pamela S

“…The decision between T cell activation and tolerance is governed by the spatial and temporal integration of diverse molecular signals and events occurring…”
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CHIPping Away at the Pathogenesis of Heart Failure by Libby, Peter, Jaiswal, Siddhartha, Lin, Amy E, Ebert, Benjamin L

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Cardiovascular Considerations Before Cancer Therapy: Gaps in Evidence and JACC: CardioOncology Expert Panel Recommendations by Raisi-Estabragh, Zahra, Murphy, Alexandra C, Ramalingam, Sivatharshini, Scherrer-Crosbie, Marielle, Lopez-Fernandez, Teresa, Reynolds, Kerry L, Aznar, Marianne, Lin, Amy E, Libby, Peter, Cordoba, Raul, Bredsen-Masley, Christine, Wechalekar, Ashu, Apperley, Jane, Cheng, Richard K, Manisty, Charlotte H

“…Baseline cardiovascular assessment before the initiation of potentially cardiotoxic cancer therapies is a key component of cardio-oncology, aiming to reduce…”
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228-POS by Lin, Amy E, Shehata, Nadine, Reich, Heather, Barth, David, Laskin, Carl, Lapinsky, Stephen, Gandhi, Shital

“…Objectives We outline a case of a woman with lupus (SLE) and antiphospholipid syndrome (APLA) at 26 weeks’ gestation who develops a complex multiorgan…”
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ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system by Lin, Amy E, Ebert, Gregor, Ow, Yongkai, Preston, Simon P, Toe, Jesse G, Cooney, James P, Scott, Hamish W, Sasaki, Masato, Saibil, Samuel D, Dissanayake, Dilan, Kim, Raymond H, Wakeham, Andrew, You-Ten, Annick, Shahinian, Arda, Duncan, Gordon, Silvester, Jennifer, Ohashi, Pamela S, Mak, Tak W, Pellegrini, Marc

“…ARIH2 is a RING-between-RING E3 ligase. Pellegrini and colleagues show that ARIH2 is needed to limit excessive NF-κB signaling in DCs. Loss of ARIH2 is…”
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Abstract 13052: Clonal Hematopoiesis of Indeterminate Potential Predicts Incident Cardiac Arrhythmias by Schuermans, Art, Vlasschaert, Caitlyn, Nauffal, Victor, Uddin, Md Mesbah, Nakao, Tetsushi, Niroula, Abhishek, Klarqvist, Marcus D, Weeks, Lachelle D, Lin, Amy E, Saadatagah, Seyedmohammad, Lannery, Kim, Wong, Megan, Hornsby, Whitney, Lubitz, Steven A, Ballantyne, Christie M, Jaiswal, Siddhartha, Bick, Alexander G, Ellinor, Patrick T, Natarajan, Pradeep, Honigberg, Michael C

“…Abstract only Background: Clonal hematopoiesis of indeterminate potential (CHIP), the age-related expansion of blood cells with preleukemic mutations, is…”
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The Association between Clonal Hematopoiesis and Gout by Agrawal, Mridul, Niroula, Abhishek, Cunin, Pierre, McConkey, Marie, Kim, Peter G., Wong, Waihay J., Weeks, Lachelle D., Lin, Amy E., Miller, Peter G., Gibson, Christopher J., Sekar, Aswin, Neuberg, Donna S., Bick, Alexander G., Natarajan, Pradeep, Nigrovic, Peter A., Rao, Deepak A., Ebert, Benjamin L.

“…▪ Background: Gout is a highly prevalent arthritis associated with debilitating joint pain and functional impairment. It is caused by elevated serum uric acid…”
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Clonal hematopoiesis and risk of chronic liver disease by Wong, Waihay J., Emdin, Connor, Bick, Alexander G., Zekavat, Seyedeh M., Niroula, Abhishek, Pirruccello, James P., Dichtel, Laura, Griffin, Gabriel, Uddin, Md Mesbah, Gibson, Christopher J., Kovalcik, Veronica, Lin, Amy E., McConkey, Marie E, Vromman, Amelie, Sellar, Rob S., Kim, Peter G., Agrawal, Mridul, Weinstock, Joshua, Long, Michelle T., Yu, Bing, Banerjee, Rajarshi, Nicholls, Rowan C., Dennis, Andrea, Kelly, Matt, Loh, Po-Ru, McCarroll, Steve, Boerwinkle, Eric, Vasan, Ramachandran S., Jaiswal, Siddhartha, Johnson, Andrew D., Chung, Raymond T., Corey, Kathleen, Levy, Daniel, Ballantyne, Christie, Ebert, Benjain L., Natarajan, Pradeep

“…Chronic liver disease is a major public health burden worldwide 1 . Although different aetiologies and mechanisms of liver injury exist, progression of chronic…”
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Abstract 15719: Proteomic Analyses Reveal Mechanistic Links Between Clonal Hematopoiesis of Indeterminate Potential and Coronary Artery Disease by Yu, Zhi, Yu, Bing, Vromman, Amelie, Nguyen, Quynh H, Khetarpal, Sumeet, Honigberg, Michael, Lin, Amy E, Katz, Daniel H, Tahir, Usman A, Weinstock, Joshua S, Jaiswal, Siddhartha, Austin, Thomas, Ramachandran, Vasan S, Peloso, Gina, Manson, Joann E, Haring, Bernhard, Kooperberg, Charles, Reiner, Alex P, Bis, Joshua, Psaty, Bruce M, Correa, Adolfo, Lange, Leslie, Post, Wendy S, Rotter, Jerome I, Rich, Stephen S, Wilson, James, Ballantyne, Christie M, Coresh, Josef, Sankaran, Vijay, Libby, Peter, Bick, Alexander G, Ebert, Benjamin L, Gerszten, Robert E, Natarajan, Pradeep

“…IntroductionClonal hematopoiesis of indeterminate potential (CHIP) is a phenomenon where hematopoietic stem cells acquire leukemogenic mutations without blood…”
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Clonal Hematopoiesis at Crossroads of Aging, Cardiovascular Diseases, and Cancer: JACC Topic of the Week by Libby, Peter, Sidlow, Robert, Lin, Amy E., Gupta, Dipti, Jones, Lee W., Moslehi, Javid, Zeiher, Andreas, Jaiswal, Siddhartha, Schulz, Christian, Blankstein, Ron, Bolton, Kelly L., Steensma, David, Levine, Ross L., Ebert, Benjamin L.

“…A novel, common, and potent cardiovascular risk factor has recently emerged: clonal hematopoiesis of indeterminate potential (CHIP). CHIP arises from somatic…”
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