Search Results - "Lin, Aifu"

Membrane-lipid associated lncRNA: A new regulator in cancer signaling by Ma, Yanxiu, Zhang, Junmei, Wen, Lixia, Lin, Aifu

“…Long noncoding RNAs (LncRNAs) are one of the emerging regulators which are involved in diverse biological processes. LncRNAs can participate in the regulation…”
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Cancer immunotherapy: an evolving paradigm by Lin, Aifu

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AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells by Wang, Shuai, Qiu, Zongyang, Hou, Yingnan, Deng, Xiya, Xu, Wei, Zheng, Tingting, Wu, Peihan, Xie, Shaofang, Bian, Weixiang, Zhang, Chong, Sun, Zewei, Liu, Kunpeng, Shan, Chao, Lin, Aifu, Jiang, Shibo, Xie, Youhua, Zhou, Qiang, Lu, Lu, Huang, Jing, Li, Xu

“…The current coronavirus disease 2019 (COVID-19) pandemic presents a global public health challenge. The viral pathogen responsible, severe acute respiratory…”
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Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming by Liu, Jia, Liu, Ze-Xian, Wu, Qi-Nian, Lu, Yun-Xin, Wong, Chau-Wei, Miao, Lei, Wang, Yun, Wang, Zixian, Jin, Ying, He, Ming-Ming, Ren, Chao, Wang, De-Shen, Chen, Dong-Liang, Pu, Heng-Ying, Feng, Lin, Li, Bo, Xie, Dan, Zeng, Mu-Sheng, Huang, Peng, Lin, Aifu, Lin, Dongxin, Xu, Rui-Hua, Ju, Huai-Qiang

“…Tumor cells often reprogram their metabolism for rapid proliferation. The roles of long noncoding RNAs (lncRNAs) in metabolism remodeling and the underlying…”
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A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid–liquid phase separation to promote oncogenic YAP signaling by Li, Rui-Hua, Tian, Tian, Ge, Qi-Wei, He, Xin-Yu, Shi, Cheng-Yu, Li, Jun-Hong, Zhang, Zhen, Liu, Fang-Zhou, Sang, Ling-Jie, Yang, Zuo-Zhen, Liu, Ya-Zhuo, Xiong, Yan, Yan, Qingfeng, Li, Xu, Ju, Huai-Qiang, Liu, Jian, Wang, Liang-Jing, Shao, Jian-Zhong, Wang, Wenqi, Zhou, Tianhua, Lin, Aifu

“…Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development…”
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Iron metabolism, ferroptosis, and lncRNA in cancer: knowns and unknowns by Qu, Lei, He, Xinyu, Tang, Qian, Fan, Xiao, Liu, Jian, Lin, Aifu

“…Cancer cells undergo substantial metabolic alterations to sustain increased energy supply and uncontrolled proliferation. As an essential trace element, iron…”
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lncRNA Directs Cooperative Epigenetic Regulation Downstream of Chemokine Signals by Xing, Zhen, Lin, Aifu, Li, Chunlai, Liang, Ke, Wang, Shouyu, Liu, Yang, Park, Peter K., Qin, Li, Wei, Yongkun, Hawke, David H., Hung, Mien-Chie, Lin, Chunru, Yang, Liuqing

“…lncRNAs are known to regulate a number of different developmental and tumorigenic processes. Here, we report a role for lncRNA BCAR4 in breast cancer…”
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Tumor immune checkpoints and their associated inhibitors by Gao, Zerui, Ling, Xingyi, Shi, Chengyu, Wang, Ying, Lin, Aifu

“…Immunological evasion is one of the defining characteristics of cancers, as the immune modification of an immune checkpoint (IC) confers immune evasion…”
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Long Noncoding RNAs, New Critical Regulators in Cancer Immunity by Wu, Minjie, Fu, Peifen, Qu, Lei, Liu, Jian, Lin, Aifu

“…Long noncoding RNAs (lncRNAs) play crucial roles in various aspects of cellular functions. Recent studies have revealed that lncRNAs are critical players in…”
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Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediated TGF-β degradation by Shen, Yingying, Lu, Chaojie, Song, Zhengbo, Qiao, Chenxiao, Wang, Jiaoli, Chen, Jinbiao, Zhang, Chengyan, Zeng, Xianchang, Ma, Zeyu, Chen, Tao, Li, Xu, Lin, Aifu, Guo, Jufeng, Wang, Jianli, Cai, Zhijian

“…TGF-β is essential for inducing systemic tumor immunosuppression; thus, blocking TGF-β can greatly enhance antitumor immunity. However, there are still no…”
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Emerging roles of RNA methylation in gastrointestinal cancers by Xie, Shanshan, Chen, Wenwen, Chen, Kanghua, Chang, Yongxia, Yang, Feng, Lin, Aifu, Shu, Qiang, Zhou, Tianhua, Yan, Xiaoyi

“…RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many…”
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LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism by Zheng, Xin, Han, Han, Liu, Guang‐Ping, Ma, Yan‐Xiu, Pan, Ruo‐Lang, Sang, Ling‐Jie, Li, Rui‐Hua, Yang, Luo‐Jia, Marks, Jeffrey R, Wang, Wenqi, Lin, Aifu

“…The Hippo pathway plays essential roles in organ size control and cancer prevention via restricting its downstream effector, Yes‐associated protein (YAP)…”
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Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review by Lin, Siyi, He, Xinyu, Wang, Ying, Chen, Yu, Lin, Aifu

“…Cells within tissues are subject to various mechanical forces, including hydrostatic pressure, shear stress, compression, and tension. These mechanical stimuli…”
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FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K-AKT Pathway by AIFU LIN, PIAO, Hai-Long, LI ZHUANG, SARBASSOV, Dos D, LI MA, BOYI GAN

“…The PI3K-AKT pathway is hyperactivated in many human cancers, and several drugs to inhibit this pathway, including the PI3K/mTOR dual inhibitor NVP-BEZ235, are…”
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Single-cell RNA sequencing unveils the hidden powers of zebrafish kidney for generating both hematopoiesis and adaptive antiviral immunity by Hu, Chongbin, Zhang, Nan, Hong, Yun, Tie, Ruxiu, Fan, Dongdong, Lin, Aifu, Chen, Ye, Xiang, Li-Xin, Shao, Jian-Zhong

“…The vertebrate kidneys play two evolutionary conserved roles in waste excretion and osmoregulation. Besides, the kidney of fish is considered as a functional…”
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LncRNAs: Architectural Scaffolds or More Potential Roles in Phase Separation by Luo, Jie, Qu, Lei, Gao, Feiran, Lin, Jun, Liu, Jian, Lin, Aifu

“…Biomolecules specifically aggregate in the cytoplasm and nucleus, driving liquid-liquid phase separation (LLPS) formation and diverse biological processes…”
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Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation by Shi, Chengyu, Wang, Ying, Wu, Minjie, Chen, Yu, Liu, Fangzhou, Shen, Zheyuan, Wang, Yiran, Xie, Shaofang, Shen, Yingying, Sang, Lingjie, Zhang, Zhen, Gao, Zerui, Yang, Luojia, Qu, Lei, Yang, Zuozhen, He, Xinyu, Guo, Yu, Pan, Chenghao, Che, Jinxin, Ju, Huaiqiang, Liu, Jian, Cai, Zhijian, Yan, Qingfeng, Yu, Luyang, Wang, Liangjing, Dong, Xiaowu, Xu, Pinglong, Shao, Jianzhong, Liu, Yang, Li, Xu, Wang, Wenqi, Zhou, Ruhong, Zhou, Tianhua, Lin, Aifu

“…Immune checkpoint blockade therapies targeting the PD-L1/PD-1 axis have demonstrated clear clinical benefits. Improved understanding of the underlying…”
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MAPK4 silencing in gastric cancer drives liver metastasis by positive feedback between cancer cells and macrophages by Li, Shuang, Guo, Dongyang, Sun, Qiang, Zhang, Lu, Cui, Yun, Liu, Min, Ma, Xixi, Liu, Yiman, Cui, Wenyu, Sun, Leimin, Teng, Lisong, Wang, Liangjing, Lin, Aifu, Liu, Wei, Zhuo, Wei, Zhou, Tianhua

“…Liver metastasis is a major cause of death in gastric cancer patients, but the underlying mechanisms are poorly understood. Through a combination of in vivo…”
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LncFASA promotes cancer ferroptosis via modulating PRDX1 phase separation by Fan, Xiao, Liu, Fangzhou, Wang, Xiang, Wang, Ying, Chen, Yu, Shi, Chengyu, Su, Xinwan, Tan, Manman, Yan, Qingfeng, Peng, Jinrong, Shao, Jianzhong, Xiong, Yan, Lin, Aifu

“…Ferroptosis, a unique type of non-apoptotic cell death resulting from iron-dependent lipid peroxidation, has a potential physiological function in tumor…”
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LncRNA modulates Hippo-YAP signaling to reprogram iron metabolism by He, Xin-yu, Fan, Xiao, Qu, Lei, Wang, Xiang, Jiang, Li, Sang, Ling-jie, Shi, Cheng-yu, Lin, Siyi, Yang, Jie-cheng, Yang, Zuo-zhen, Lei, Kai, Li, Jun-hong, Ju, Huai-qiang, Yan, Qingfeng, Liu, Jian, Wang, Fudi, Shao, Jianzhong, Xiong, Yan, Wang, Wenqi, Lin, Aifu

“…Iron metabolism dysregulation is tightly associated with cancer development. But the underlying mechanisms remain poorly understood. Increasing evidence has…”
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