Search Results - "Limpens, Ronald W A L"

A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis by Snijder, Eric J, Limpens, Ronald W A L, de Wilde, Adriaan H, de Jong, Anja W M, Zevenhoven-Dobbe, Jessika C, Maier, Helena J, Faas, Frank F G A, Koster, Abraham J, Bárcena, Montserrat

“…Zoonotic coronavirus (CoV) infections, such as those responsible for the current severe acute respiratory syndrome-CoV 2 (SARS-CoV-2) pandemic, cause grave…”
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Ultrastructural Characterization of Arterivirus Replication Structures: Reshaping the Endoplasmic Reticulum To Accommodate Viral RNA Synthesis by KNOOPS, Kèvin, BARCENA, Montserrat, LIMPENS, Ronald W. A. L, KOSTER, Abraham J, MIEKE MOMMAAS, A, SNIJDER, Eric J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A molecular pore spans the double membrane of the coronavirus replication organelle by Wolff, Georg, Limpens, Ronald W. A. L., Zevenhoven-Dobbe, Jessika C., Laugks, Ulrike, Zheng, Shawn, de Jong, Anja W. M., Koning, Roman I., Agard, David A., Grünewald, Kay, Koster, Abraham J., Snijder, Eric J., Bárcena, Montserrat

“…Viral RNA exported from the coronavirus replication organelle is likely to be mediated by a crown-shaped molecular pore. A gateway to the cytosol Coronaviruses…”
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Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication by Oudshoorn, Diede, Rijs, Kevin, Limpens, Ronald W A L, Groen, Kevin, Koster, Abraham J, Snijder, Eric J, Kikkert, Marjolein, Bárcena, Montserrat

“…Betacoronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV), are important pathogens causing potentially lethal infections in humans and…”
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The transformation of enterovirus replication structures: a three-dimensional study of single- and double-membrane compartments by Limpens, Ronald W A L, van der Schaar, Hilde M, Kumar, Darshan, Koster, Abraham J, Snijder, Eric J, van Kuppeveld, Frank J M, Bárcena, Montserrat

“…All positive-strand RNA viruses induce membrane structures in their host cells which are thought to serve as suitable microenvironments for viral RNA…”
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Antimicrobial Peptide P60.4Ac-Containing Creams and Gel for Eradication of Methicillin-Resistant Staphylococcus aureus from Cultured Skin and Airway Epithelial Surfaces by Haisma, Elisabeth M, Göblyös, Anikó, Ravensbergen, Bep, Adriaans, Alwin E, Cordfunke, Robert A, Schrumpf, Jasmijn, Limpens, Ronald W A L, Schimmel, Kirsten J M, den Hartigh, Jan, Hiemstra, Pieter S, Drijfhout, Jan Wouter, El Ghalbzouri, Abdoelwaheb, Nibbering, Peter H

“…We previously found the LL-37-derived peptide P60.4Ac to be effective against methicillin-resistant Staphylococcus aureus (MRSA) on human epidermal models…”
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Internalization of Oncolytic Reovirus by Human Dendritic Cell Carriers Protects the Virus from Neutralization by LLETT, Elizabeth J, BARCENA, Montserrat, HOEBEN, Rob C, VILE, Richard G, MELCHER, Alan A, ERRINGTON-MAIS, Fiona, GRIFFIN, Stephen, HARRINGTON, Kevin J, PANDHA, Hardev S, COFFEY, Matthew, SELBY, Peter J, LIMPENS, Ronald W. A. L, MOMMAAS, Mieke

“…Dendritic cells (DC) may be the most effective way of delivering oncolytic viruses to patients. Reovirus, a naturally occurring oncolytic virus, is currently…”
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Antiviral Innate Immune Response Interferes with the Formation of Replication-Associated Membrane Structures Induced by a Positive-Strand RNA Virus by Oudshoorn, Diede, van der Hoeven, Barbara, Limpens, Ronald W A L, Beugeling, Corrine, Snijder, Eric J, Bárcena, Montserrat, Kikkert, Marjolein

“…Infection with nidoviruses like corona- and arteriviruses induces a reticulovesicular network of interconnected endoplasmic reticulum (ER)-derived…”
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SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology by Ogando, Natacha S, Dalebout, Tim J, Zevenhoven-Dobbe, Jessika C, Limpens, Ronald W A L, van der Meer, Yvonne, Caly, Leon, Druce, Julian, de Vries, Jutte J C, Kikkert, Marjolein, Bárcena, Montserrat, Sidorov, Igor, Snijder, Eric J

“…The sudden emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the end of 2019 from the Chinese province of Hubei and its subsequent…”
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MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment by de Wilde, Adriaan H, Raj, V Stalin, Oudshoorn, Diede, Bestebroer, Theo M, van Nieuwkoop, Stefan, Limpens, Ronald W A L, Posthuma, Clara C, van der Meer, Yvonne, Bárcena, Montserrat, Haagmans, Bart L, Snijder, Eric J, van den Hoogen, Bernadette G

“…Coronavirus (CoV) infections are commonly associated with respiratory and enteric disease in humans and animals. The 2003 outbreak of severe acute respiratory…”
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Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions by Short, Kirsty R, Kasper, Jennifer, van der Aa, Stijn, Andeweg, Arno C, Zaaraoui-Boutahar, Fatiha, Goeijenbier, Marco, Richard, Mathilde, Herold, Susanne, Becker, Christin, Scott, Dana P, Limpens, Ronald W A L, Koster, Abraham J, Bárcena, Montserrat, Fouchier, Ron A M, Kirkpatrick, Charles James, Kuiken, Thijs

“…A major cause of respiratory failure during influenza A virus (IAV) infection is damage to the epithelial-endothelial barrier of the pulmonary alveolus. Damage…”
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Mind the gap: Micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae by Wolff, Georg, Limpens, Ronald W.A.L., Zheng, Shawn, Snijder, Eric J., Agard, David A., Koster, Abraham J., Bárcena, Montserrat

“…[Display omitted] •Micro-expansion joints greatly increase the cryo-FIB-milling success rate.•These lateral gaps milled in the support prevent cryo-lamellae…”
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Organoid-based expansion of patient-derived primary alveolar type 2 cells for establishment of alveolus epithelial Lung-Chip cultures by van Riet, Sander, van Schadewijk, Annemarie, Khedoe, P Padmini S J, Limpens, Ronald W A L, Bárcena, Montserrat, Stolk, Jan, Hiemstra, Pieter S, van der Does, Anne M

“…Development of effective treatment strategies for lung tissue destruction as seen in emphysema would greatly benefit from representative human in vitro models…”
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Diabetic Nephropathy Alters the Distribution of Circulating Angiogenic MicroRNAs Among Extracellular Vesicles, HDL, and Ago-2 by Florijn, Barend W, Duijs, Jacques M G J, Levels, Johannes H, Dallinga-Thie, Geesje M, Wang, Yanan, Boing, Anita N, Yuana, Yuana, Stam, Wendy, Limpens, Ronald W A L, Au, Yu Wah, Nieuwland, Rienk, Rabelink, Ton J, Reinders, Marlies E J, van Zonneveld, Anton Jan, Bijkerk, Roel

“…Previously, we identified plasma microRNA (miR) profiles that associate with markers of microvascular injury in patients with diabetic nephropathy (DN)…”
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Evaluation of PLGA, lipid-PLGA hybrid nanoparticles, and cationic pH-sensitive liposomes as tuberculosis vaccine delivery systems in a Mycobacterium tuberculosis challenge mouse model – A comparison by Szachniewicz, Mikołaj M., Neustrup, Malene A., van den Eeden, Susan J.F., van Meijgaarden, Krista E., Franken, Kees L.M.C., van Veen, Suzanne, Koning, Roman I., Limpens, Ronald W.A.L., Geluk, Annemieke, Bouwstra, Joke A., Ottenhoff, Tom H.M.

“…[Display omitted] •Nanoparticle-based vaccines protected mice against M. tuberculosis infection.•PLGA-based vaccines showed the largest reduction in bacterial…”
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Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles by Melia, Charlotte E., van der Schaar, Hilde M., Lyoo, Heyrhyoung, Limpens, Ronald W.A.L., Feng, Qian, Wahedi, Maryam, Overheul, Gijs J., van Rij, Ronald P., Snijder, Eric J., Koster, Abraham J., Bárcena, Montserrat, van Kuppeveld, Frank J.M.

“…Enteroviruses reorganize cellular endomembranes into replication organelles (ROs) for genome replication. Although enterovirus replication depends on…”
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Estradiol-driven metabolism in transwomen associates with reduced circulating extracellular vesicle microRNA-224/452 by Florijn, Barend W, Duijs, Jacques M G J, Klaver, Maartje, Kuipers, Eline N, Kooijman, Sander, Prins, Jurrien, Zhang, Huayu, Sips, Hetty C M, Stam, Wendy, Hanegraaf, Maaike, Limpens, Ronald W A L, Nieuwland, Rienk, van Rijn, Bas B, Rabelink, Ton J, Rensen, Patrick C N, den Heijer, Martin, Bijkerk, Roel, van Zonneveld, Anton Jan

“…Objective Sex steroid hormones like estrogens have a key role in the regulation of energy homeostasis and metabolism. In transwomen, gender-affirming hormone…”
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Mycobacteria develop biofilms on airway epithelial cells and promote mucosal barrier disruption by Barclay, Amy M., Ninaber, Dennis K., Limpens, Ronald W.A. L., Walburg, Kimberley V., Bárcena, Montserrat, Hiemstra, Pieter S., Ottenhoff, Tom H.M., van der Does, Anne M., Joosten, Simone A.

“…Tuberculosis displays several features commonly linked to biofilm-associated infections, including recurrence of infection and resistance to antibiotic…”
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Erratum. Diabetic Nephropathy Alters the Distribution of Circulating Angiogenic MicroRNAs Among Extracellular Vesicles, HDL, and Ago-2. Diabetes 2019;68:2287–2300 by Florijn, Barend W., Duijs, Jacques M.G.J., Levels, Johannes H., Dallinga-Thie, Geesje M., Wang, Yanan, Boing, Anita N., Yuana, Yuana, Stam, Wendy, Limpens, Ronald W.A.L., Au, Yu Wah, Nieuwland, Rienk, Rabelink, Ton J., Reinders, Marlies E.J., Jan van Zonneveld, Anton, Bijkerk, Roel

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