Search Results - "Limegrover, Colleen"

Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology by Szebényi, Kornélia, Wenger, Léa M. D., Sun, Yu, Dunn, Alexander W. E., Limegrover, Colleen A., Gibbons, George M., Conci, Elena, Paulsen, Ole, Mierau, Susanna B., Balmus, Gabriel, Lakatos, András

“…Amyotrophic lateral sclerosis overlapping with frontotemporal dementia (ALS/FTD) is a fatal and currently untreatable disease characterized by rapid cognitive…”
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Sigma‐2 receptor antagonists rescue neuronal dysfunction induced by Parkinson’s patient brain‐derived α‐synuclein by Limegrover, Colleen S., Yurko, Raymond, Izzo, Nicholas J., LaBarbera, Kelsie M., Rehak, Courtney, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Catalano, Susan M.

“…α‐Synuclein oligomers are thought to have a pivotal role in sporadic and familial Parkinson's disease (PD) and related α‐synucleinopathies, causing…”
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Alzheimer’s protection effect of A673T mutation may be driven by lower Aβ oligomer binding affinity by Limegrover, Colleen S., LeVine, Harry, Izzo, Nicholas J., Yurko, Raymond, Mozzoni, Kelsie, Rehak, Courtney, Sadlek, Kelsey, Safferstein, Hank, Catalano, Susan M.

“…Several mutations conferring protection against Alzheimer's disease (AD) have been described, none as profound as the A673T mutation, where carriers are four…”
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Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification by Izzo, Nicholas J., Yuede, Carla M., LaBarbera, Kelsie M., Limegrover, Colleen S., Rehak, Courtney, Yurko, Raymond, Waybright, Lora, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Hamby, Mary E., Williams, Claire, Sadlek, Kelsey, Edwards, Hannah M., Davis, Charles S., Grundman, Michael, Schneider, Lon S., DeKosky, Steven T., Chelsky, Daniel, Pike, Ian, Henstridge, Christopher, Blennow, Kaj, Zetterberg, Henrik, LeVine, Harry, Spires‐Jones, Tara L., Cirrito, John R., Catalano, Susan M.

“…Introduction Amyloid beta (Aβ) oligomers are one of the most toxic structural forms of the Aβ protein and are hypothesized to cause synaptotoxicity and memory…”
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Discovery of Investigational Drug CT1812, an Antagonist of the Sigma‑2 Receptor Complex for Alzheimer’s Disease by Rishton, Gilbert M, Look, Gary C, Ni, Zhi-Jie, Zhang, Jason, Wang, Yingcai, Huang, Yaodong, Wu, Xiaodong, Izzo, Nicholas J, LaBarbera, Kelsie M, Limegrover, Colleen S, Rehak, Courtney, Yurko, Raymond, Catalano, Susan M

“…An unbiased phenotypic neuronal assay was developed to measure the synaptotoxic effects of soluble Aβ oligomers. A collection of CNS druglike small molecules…”
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Modeling the mature CNS: A predictive screening platform for neurodegenerative disease drug discovery by LaBarbera, Kelsie Mozzoni, Limegrover, Colleen, Rehak, Courtney, Yurko, Raymond, Izzo, Nicholas John, Knezovich, Nicole, Watto, Emily, Waybright, Lora, Catalano, Susan M.

“…Mature primary neuronal cultures are an important model of the nervous system, but limited scalability has been a major challenge in their use for drug…”
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