Search Results - "Lima Fuscaldi, Leonardo"

Kinetic modeling of 68Ga-PSMA-11 and validation of simplified methods for quantification in primary prostate cancer patients by Ringheim, Anna, Campos Neto, Guilherme de Carvalho, Anazodo, Udunna, Cui, Lumeng, da Cunha, Marcelo Livorsi, Vitor, Taise, Martins, Karine Minaif, Miranda, Ana Cláudia Camargo, de Barboza, Marycel Figols, Fuscaldi, Leonardo Lima, Lemos, Gustavo Caserta, Colombo Junior, José Roberto, Baroni, Ronaldo Hueb

“…Background The positron emission tomography (PET) ligand 68 Ga-Glu-urea-Lys(Ahx)-HBED-CC ( 68 Ga-PSMA-11) targets the prostate-specific membrane antigen…”
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EGFR- and Integrin αVβ3-Targeting Peptides as Potential Radiometal-Labeled Radiopharmaceuticals for Cancer Theranostics by Rodrigues Toledo, Cibele, Tantawy, Ahmed A., Lima Fuscaldi, Leonardo, Malavolta, Luciana, de Aguiar Ferreira, Carolina

“…The burgeoning field of cancer theranostics has witnessed advancements through the development of targeted molecular agents, particularly peptides. These…”
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New approach for in-house production of [68Ga]Ga-NOTA-UBI(29–41) using a titanium dioxide column-based generator by Santos, Caiubi Rodrigues de Paula, Fuscaldi, Leonardo Lima, Durante, Ana Claudia Ranucci, de Barboza, Marycel Figols, Malavolta, Luciana

“…Efforts have been dedicated to distinguishing between infections and sterile inflammations. This study presents a novel approach for in-house synthesis of [ 68…”
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Bimatoprost-loaded ocular inserts as sustained release drug delivery systems for glaucoma treatment: in vitro and in vivo evaluation by Franca, Juçara Ribeiro, Foureaux, Giselle, Fuscaldi, Leonardo Lima, Ribeiro, Tatiana Gomes, Rodrigues, Lívia Bomfim, Bravo, Renata, Castilho, Rachel Oliveira, Yoshida, Maria Irene, Cardoso, Valbert Nascimento, Fernandes, Simone Odília, Cronemberger, Sebastião, Ferreira, Anderson José, Faraco, André Augusto Gomes

“…The purpose of the present study was to develop and assess a novel sustained-release drug delivery system of Bimatoprost (BIM). Chitosan polymeric inserts were…”
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EVALUATION OF POTENTIAL PEPTIDE INHIBITORS THAT INTERACT WITH THE EGF RECEPTOR. RELEVANCE TO GLIOBLASTOMA by Lorena Marinelli Mendes, Danielle Vieira Sobral, Érica Victória dos Santos, Leonardo Lima Fuscaldi, Luciana Malavolta

“…Introduction/Justification: Peptides are implicated to various physiological responses and exhibit considerable potential for disease treatment, encompassing…”
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INVESTIGATION OF THE IN VITRO ASSESSMENT OF 99MTC-LABELED LAMININ-111 PEPTIDES AS PROSPECTIVE BIOMARKERS FOR BREAST CANCER by Fernanda Ferreira Mendonça, Maria Emilia Tejeria Perez, Paula Decuadra, Maia Zeni, Ana Rey, Leonardo Lima Fuscaldi, Luciana Malavolta

“…Introduction/Justification: Breast cancer constitutes a significant public health issue as the second most prevalent type of tumor among women. In the past…”
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SYNTHESIS AND EVALUATION OF BIOACTIVE PEPTIDES FROM LAMININ-111 IN TRIPLE-NEGATIVE BREAST CANCER CELLS by Fernanda Ferreira Mendonça, Júlia Torquato Vieira, Danielle Vieira Sobral, Érica Victória dos Santos, Leonardo Lima Fuscaldi, Luciana Malavolta

“…Introduction/Justification: Breast cancer stands as the neoplasm group with the highest incidence rate among women worldwide. Laminin-111 a constituent of the…”
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The magnitude of physical exercise-induced hyperthermia is associated with changes in the intestinal permeability and expression of tight junction genes in rats by Ribeiro Hudson, Alexandre Sérvulo, Nascimento Soares, Anne Danieli, Coelho Horta, Nayara Abreu, Fuscaldi, Leonardo Lima, Machado-Moreira, Christiano Antônio, Soares, Danusa Dias, Coimbra, Cândido Celso, de Oliveira Poletini, Maristela, Cardoso, Valbert Nascimento, Wanner, Samuel Penna

“…We investigated whether the magnitude of exercise-induced hyperthermia influences intestinal permeability and tight junction gene expression. Twenty-nine male…”
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Radiosynthesis Standardization and Preclinical Assessment of the [68Ga]Ga-DOTA-Ubiquicidin29-41: A Translational Study Targeting Differential Diagnosis of Infectious Processes by Miranda, Ana Cláudia Camargo, Fuscaldi, Leonardo Lima, Mejia, Jorge, da Silva, Fábio Fernando Alves, Turato, Walter Miguel, Mendonça, Fernanda Ferreira, Nogueira, Solange Amorim, Osawa, Akemi, Yamaga, Lilian Yuri Itaya, Malavolta, Luciana, de Barboza, Marycel Figols

“…Human bacterial infections significantly contribute to the increase in healthcare-related burdens. This scenario drives the study of novel techniques for the…”
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68GA-NOTA-UBI AND 68GA-DOTA-UBI AS RADIOPHARMACEUTICALS FOR THE DIAGNOSIS OF INFECTIOUS PROCESSES: PRECLINICAL STUDIES AND TRANSLATION TO CLINICAL APPLICATION by Ana Claudia Camargo Miranda, Caiubi Rodrigues de Paula Santos, Leonardo Lima Fuscaldi, Fernanda Ferreira Mendonça, Solange Amorim Nogueira, Jorge Mejia, Akemi Osawa, Lilian Yuri Itaya Yamaga, Marycel Figols de Barboza, Luciana Malavolta

“…Introduction/Justification: Infectious diseases are the second leading cause of mortality worldwide. In this context, considerable efforts are being made to…”
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ASSESSMENT OF IN VITRO STUDIES OF [131I]I-LABELED DEDEYFELV PEPTIDE AS PROSPECTIVE BIOMARKER FOR GLIOBLASTOMA by Fernanda Paiva Augusto Rodrigues, Júlia Calviello Giordano, Danielle Vieira Sobral, Ana Cláudia Camargo Miranda, Leonardo Lima Fuscaldi, Marycel Figols de Barboza, João Luiz Vitorino Araújo, Luciana Malavolta

“…Introduction/Justification: Glioblastomas (GBM) constitute the most prevalent malignant primary tumor in adults and rank as the third most frequent tumors in…”
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SYNTHESIS, CHARACTERIZATION, AND RADIOLABELING OF MODIFIED PEPTIDE FRAGMENTS TARGETING ΑVΒ3 INTEGRIN ADHESION MOLECULE OVEREXPRESSED IN TUMORS by Gabriella Fraiji Melo, Fernanda Ferreira Mendonça, Danielle Vieira Sobral, Flávio Lopes Alves, Carolina de Aguiar Ferreira, Leonardo Lima Fuscaldi, Luciana Malavolta

“…Introduction/Justification: Peptides are biomolecules that have been associated with various physiological responses and have great potential for the diagnosis…”
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AUTOMATED SYNTHESIS AND IN VITRO STUDIES OF [68GA]GA-FAPI-46 IN HOSPITAL RADIOPHARMACY by Leonardo Lima Fuscaldi, Paloma Caiado Lupinari, Karen Alessandra Kazumi Sato, Ana Claudia Camargo Miranda, Solange Nogueira Amorim, Taise Vitor, Jairo Wagner, Vasko Kramer, Lilian Yuri Itaya Yamaga, Luciana Malavolta, Marycel Figols de Barboza

“…Introduction/Justification: Early evidence appointed fibroblast activation protein (FAP), a type II transmembrane serine protease, as highly expressed in the…”
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ASSESSMENT OF IN VITRO INTERACTIONS BETWEEN RADIOLABELED EGFR-TARGETING PEPTIDE INHIBITORS AND GLIOBLASTOMA CELLS by Fernanda Ferreira Mendonça, Alice Santos de Miranda, Henrique Massao Achidate Makino, Lorena Marinelli Mendes, Danielle Vieira Sobral, Marycel Figols de Barboza, Luciana Malavolta, Leonardo Lima Fuscaldi

“…Introduction/Justification: Peptides are implicated in various physiological responses and hold significant potential as targeting molecules, especially in…”
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Ocular Inserts for Sustained Release of the Angiotensin-Converting Enzyme 2 Activator, Diminazene Aceturate, to Treat Glaucoma in Rats by Foureaux, Giselle, Franca, Juçara Ribeiro, Nogueira, José Carlos, Fulgêncio, Gustavo de Oliveira, Ribeiro, Tatiana Gomes, Castilho, Rachel Oliveira, Yoshida, Maria Irene, Fuscaldi, Leonardo Lima, Fernandes, Simone Odília Antunes, Cardoso, Valbert Nascimento, Cronemberger, Sebastião, Faraco, André Augusto Gomes, Ferreira, Anderson José

“…The aim of this study was to develop and evaluate the effects of chitosan inserts for sustained release of the angiotensin-converting enzyme 2 (ACE2)…”
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INFLUENCE OF A CONVENTIONAL CHELATOR-MODIFIED ANTI-INTEGRIN PEPTIDE ON PROLIFERATION AND MIGRATION OF HEAD AND NECK CANCER CELLS by Juliana Carron, Daniele Daiane Affonso, Suelen Aparecida Ribeiro Souza, Ana Maria Castro Ferreira, João Ernesto Carvalho, Ana Lucia Tasca Gois Ruiz, Gabriella Fraiji Melo, Flávio Lopes Alves, Leonardo Lima Fuscaldi, Luciana Malavolta, Carmen Silvia Passos Lima

“…Introduction/Justification: Head and neck squamous cell carcinoma (HNSCC) represents a serious health problem worldwide. Approximately 75% of patients with…”
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Radioimmunotheranostic Pair Based on the Anti-HER2 Monoclonal Antibody: Influence of Chelating Agents and Radionuclides on Biological Properties by Miranda, Ana Cláudia Camargo, Dos Santos, Sofia Nascimento, Fuscaldi, Leonardo Lima, Balieiro, Luiza Mascarenhas, Bellini, Maria Helena, Guimarães, Maria Inês Calil Cury, de Araújo, Elaine Bortoleti

“…The oncogene HER2 is an important molecular target in oncology because it is associated with aggressive disease and the worst prognosis. The development of…”
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Current Approach in Radiochemical Quality Control of the 99mTc-Radiopharmaceuticals: a mini-review by Miranda, Ana Cláudia Camargo, Durante, Ana Claudia Ranucci, Fuscaldi, Leonardo Lima, Barboza, Marycel Figols de

“…Abstract To present optimized chromatographic systems for radiochemical purity (RCP) evaluation of 99mTc-eluate and 99mTc-radiopharmaceuticals, as well as to…”
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Synthesis and antimicrobial evaluation of two peptide LyeTx I derivatives modified with the chelating agent HYNIC for radiolabeling with technetium-99m by Fuscaldi, Leonardo Lima, Dos Santos, Daniel Moreira, Pinheiro, Natália Gabriela Silva, Araújo, Raquel Silva, de Barros, André Luís Branco, Resende, Jarbas Magalhães, Fernandes, Simone Odília Antunes, de Lima, Maria Elena, Cardoso, Valbert Nascimento

“…Current diagnostic methods and imaging techniques are not able to differentiate septic and aseptic inflammation. Thus, reliable methods are sought to provide…”
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EGFR- and Integrin α[sub.V]β[sub.3]-Targeting Peptides as Potential Radiometal-Labeled Radiopharmaceuticals for Cancer Theranostics by Rodrigues Toledo, Cibele, Tantawy, Ahmed A, Lima Fuscaldi, Leonardo, Malavolta, Luciana, de Aguiar Ferreira, Carolina

“…The burgeoning field of cancer theranostics has witnessed advancements through the development of targeted molecular agents, particularly peptides. These…”
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