Search Results - "Lima E Lima, Anderson"
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Predicting cell-penetrating peptides using machine learning algorithms and navigating in their chemical space
Published in Scientific reports (07-04-2021)“…Cell-penetrating peptides (CPPs) are naturally able to cross the lipid bilayer membrane that protects cells. These peptides share common structural and…”
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Applications of Virtual Screening in Bioprospecting: Facts, Shifts, and Perspectives to Explore the Chemo-Structural Diversity of Natural Products
Published in Frontiers in chemistry (29-04-2021)“…Natural products are continually explored in the development of new bioactive compounds with industrial applications, attracting the attention of scientific…”
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Unraveling the conformational dynamics of glycerol 3-phosphate dehydrogenase, a nicotinamide adenine dinucleotide-dependent enzyme of Leishmania mexicana
Published in Journal of biomolecular structure & dynamics (31-03-2021)“…Allosteric changes modulate the enzymatic activity, leading to activation or inhibition of the molecular target. Understanding the induced fit accommodation…”
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Investigating molecular descriptors in cell-penetrating peptides prediction with deep learning: Employing N, O, and hydrophobicity according to the Eisenberg scale
Published in PloS one (13-06-2024)“…Cell-penetrating peptides comprise a group of molecules that can naturally cross the lipid bilayer membrane that protects cells, sharing physicochemical and…”
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Insight into the Interaction Mechanism of Nicotine, NNK, and NNN with Cytochrome P450 2A13 Based on Molecular Dynamics Simulation
Published in Journal of chemical information and modeling (24-02-2020)“…Tobacco smoke contains various cancer-causing toxic substances, including nicotine and nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and…”
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Computational study of conformational changes in human 3-hydroxy-3-methylglutaryl coenzyme reductase induced by substrate binding
Published in Journal of biomolecular structure & dynamics (02-11-2019)“…The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is mainly involved in the regulation of cholesterol biosynthesis. HMGR catalyses the…”
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Using Accelerated Molecular Dynamics Simulation to elucidate the effects of the T198F mutation on the molecular flexibility of the West Nile virus envelope protein
Published in Scientific reports (15-06-2020)“…The envelope (E) protein is an important target for antibodies in flavivirus. Literature reports that the mutation T198F, located at the domain I-II hinge of…”
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Exploring the Potentiality of Natural Products from Essential Oils as Inhibitors of Odorant-Binding Proteins: A Structure- and Ligand-Based Virtual Screening Approach To Find Novel Mosquito Repellents
Published in ACS omega (31-12-2019)“…Odorant-binding proteins (OBPs) are the main olfactory proteins of mosquitoes, and their structures have been widely explored to develop new repellents. In the…”
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Harnessing Brazilian biodiversity database: identification of flavonoids as potential inhibitors of SARS-CoV-2 main protease using computational approaches and all-atom molecular dynamics simulation
Published in Frontiers in chemistry (22-02-2024)“…SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) is the etiological agent responsible for the global outbreak of COVID-19 (Coronavirus Disease…”
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Structural analysis of viral infectivity factor of HIV type 1 and its interaction with A3G, EloC and EloB
Published in PloS one (26-02-2014)“…The virion infectivity factor (Vif) is an accessory protein, which is essential for HIV replication in host cells. Vif neutralizes the antiviral host protein…”
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Efficacy of Continuous S(+)-Ketamine Infusion for Postoperative Pain Control: A Randomized Placebo-Controlled Trial
Published in Anesthesiology Research and Practice (01-01-2016)“…Aim. A double-blind, randomized, placebo-controlled trial was designed to evaluate the efficacy of continuous intraoperative infusion of S(+)-ketamine under…”
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Expanding anti-venom strategies: Camelid polyclonal antibodies with high capacity to recognize snake venom
Published in Toxicon (Oxford) (28-08-2024)“…Camelid immunoglobulins represent a unique facet of antibody biology, challenging conventional understandings of antibody diversification. IgG2 and IgG3 in…”
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Métodos semiempíricos de química quântica no ensino da entalpia das reações químicas
Published in Scientia plena (27-05-2016)“…A carência de métodos para auxiliar o ensino Química torna o assunto desafiador diante das didáticas de ensino. No entanto, pesquisas têm sido feitas para…”
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Compostagem de resíduos sólidos orgânicos como tema incentivador de educação ambiental
Published in Scientia plena (27-05-2016)“…O presente trabalho diz respeito a uma prática ambiental promovida com a cooperação de alunos do ensino fundamental de uma escola localizada no município de…”
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BjussuMP-II, a venom metalloproteinase, induces the release and cleavage of pro-inflammatory cytokines and disrupts human umbilical vein endothelial cells
Published in Chemico-biological interactions (01-05-2024)“…Snake venom metalloproteases (SVMPs) are hydrolytic enzymes dependent on metal binding, primarily zinc (Zn2+), at their catalytic site. They are classified…”
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Clinical-epidemiological assessment of patients undergoing bariatric and metabolic surgery in a medium-complexity service in Maranhão, Brazil
Published in Revista do Colegio Brasileiro de Cirurgioes (2024)“…the obesity is defined as the excessive accumulation of fat in different areas of the body, a condition that causes damage to health and is a critical risk…”
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DEMOCRACIA E JURISDIÇÃO: ASPECTOS POLÍTICO-JURÍDICOS DOS LEGITIMADOS A PROPOR AÇÕES DE INCONSTITUCIONALIDADE JUNTO AO SUPREMO TRIBUNAL FEDERAL
Published in RELACult (10-05-2018)“…Tradicionalmente a interpretação constitucional tem sido encarada como uma atividade eminentemente técnica, restrita, portanto, aos profissionais do meio…”
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DEMOCRACIA E JURISDIÇÃO: ASPECTOS POLÍTICO-JURÍDICOS DOS LEGITIMADOS A PROPOR AÇÕES DE INCONSTITUCIONALIDADE JUNTO AO SUPREMO TRIBUNAL FEDERAL
Published in RELACult (10-05-2018)“…Tradicionalmente a interpretação constitucional tem sido encarada como uma atividade eminentemente técnica, restrita, portanto, aos profissionais do meio…”
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Avaliação clínico-epidemiológica de pacientes submetidos à cirurgia bariátrica e metabólica em um serviço de média complexidade no Maranhão
Published in Revista do Colégio Brasileiro de Cirurgiões (2024)“…RESUMO Introdução: a obesidade é definida pelo acúmulo excessivo de gordura em diferentes regiões corporais, condição que acarreta prejuízos à saúde e…”
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Parceria AMAN-UNITAU: uma revisão integrativa das dissertações do Curso de Mestrado Profissional em Educação da UNITAU, no contexto do Programa de Capacitação do Corpo Permanente da AMAN
Published in Revista Agulhas Negras (12-12-2023)“…Este artigo tem como objetivo realizar uma revisão integrativa das dissertações de mestrado dos oficiais-alunos do Curso de Mestrado Profissional em Educação…”
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