Search Results - "Lima‐Júnior, R C P"
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α-Phellandrene attenuates tissular damage, oxidative stress, and TNF-α levels on acute model ifosfamide-induced hemorrhagic cystitis in mice
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-10-2020)“…Hemorrhagic cystitis (HC) is the major dose-limiting adverse effect of the clinical use ifosfamide (IFOS). The incidence of this side effect can be as high as…”
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Targeted inhibition of IL‐18 attenuates irinotecan‐induced intestinal mucositis in mice
Published in British journal of pharmacology (01-05-2014)“…Background and Purpose Intestinal mucositis is a common side‐effect of irinotecan‐based cancer chemotherapy regimens. This mucositis is associated with…”
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Correction to: α-Phellandrene attenuates tissular damage, oxidative stress, and TNF-α levels on acute model ifosfamide-induced hemorrhagic cystitis in mice
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-12-2020)“…The published online version contains figure in poor quality…”
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Immune cell profile of dental pulp tissue treated with zoledronic acid
Published in International endodontic journal (01-11-2017)“…Aim To characterize the pulp immune cell profile in the teeth of rats treated with zoledronic acid (ZA). Methodology Male Wistar rats (n = 6 per group)…”
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Could paraprobiotics be a safer alternative to probiotics for managing cancer chemotherapy-induced gastrointestinal toxicities?
Published in Brazilian journal of medical and biological research (01-01-2022)“…Clinical oncology has shown outstanding progress improving patient survival due to the incorporation of new drugs. However, treatment success may be reduced by…”
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Targeted inhibition of IL-18 attenuates irinotecaninduced intestinal mucositis in mice
Published in British journal of pharmacology (01-05-2014)Get full text
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Bothrops jararacussu snake venom-induces a local inflammatory response in a prostanoid- and neutrophil-dependent manner
Published in Toxicon (Oxford) (01-11-2014)“…Local tissue reactions provoked by Bothrops venoms are characterized by edema, hemorrhage, pain, and inflammation; however, the mechanisms of tissue damage…”
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Amifostine protects from the peripheral sensory neuropathy induced by oxaliplatin in mice
Published in Brazilian journal of medical and biological research (01-01-2020)“…Sensory neuropathy is a dose-limiting side effect of oxaliplatin-based cancer treatment. This study investigated the antinociceptive effect of amifostine and…”
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IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice
Published in Mucosal immunology (01-09-2014)“…Intestinal damage and severe diarrhea are serious side effects of cancer chemotherapy and constrain the usage of most such therapies. Here we show that…”
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Blockade of TRPA1 with HC-030031 attenuates visceral nociception by a mechanism independent of inflammatory resident cells, nitric oxide and the opioid system
Published in European journal of pain (01-02-2013)“…Background Some studies have shown a somatic nociceptive response due to the activation of transient receptor potential A1 channels (TRPA1), which is modulated…”
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Immune cellular profile of bisphosphonate-related osteonecrosis of the jaw
Published in Oral diseases (01-10-2016)“…Objectives Characterize the cell profile and immunostaining of proinflammatory markers in an experimental model of bisphosphonate‐related osteonecrosis of the…”
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Could paraprobiotics be a safer alternative to probiotics for managing cancer chemotherapyinduced gastrointestinal toxicities?
Published in Brazilian journal of medical and biological research (01-01-2022)“…Clinical oncology has shown outstanding progress improving patient survival due to the incorporation of new drugs. However, treatment success may be reduced by…”
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Assessing the reaction to and efficacy of the Screener drug discovery and development board game as a pedagogical tool in postgraduate courses
Published in Brazilian journal of medical and biological research (01-01-2024)“…Screener, a board game supplemented with online resources, was introduced and distributed by the Brazilian Society of Pharmacology and Experimental…”
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Amifostine reduces inflammation and protects against 5-fluorouracil-induced oral mucositis and hyposalivation
Published in Brazilian journal of medical and biological research (01-01-2019)“…Oral mucositis (OM) is a common and dose-limiting side effect of cancer treatment, including 5-fluorouracil (5-FU) and radiotherapy. The efficacy of the…”
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1,8-cineole (eucalyptol), a monoterpene oxide attenuates the colonic damage in rats on acute TNBS-colitis
Published in Food and chemical toxicology (01-04-2004)“…The monoterpene oxide, 1,8-cineole (cineole, eucalyptol) was examined for its possible influence on the acute phase of trinitrobenzene sulfonic acid…”
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Modulation of acute visceral nociception and bladder inflammation by plant triterpene, alpha, beta-amyrin in a mouse model of cystitis: role of tachykinin NK(1)-receptors, and K(+)(ATP) channels
Published in Inflammation research (01-12-2007)“…We previously described the visceral antinociceptive property of alpha, beta-amyrin in a mouse model of cystitis induced by cyclophosphamide (CPM). This study…”
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Modulation of acute visceral nociception and bladder inflammation by plant triterpene, [alpha], [beta]-amyrin in a mouse model of cystitis: role of tachykinin NK1-receptors, and K+ ATP channels
Published in Inflammation research (01-12-2007)“…We previously described the visceral antinociceptive property of α, β-amyrin in a mouse model of cystitis induced by cyclophosphamide (CPM). This study…”
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