Effects of the solid lipid nanoparticle of carvacrol on rodents with lung injury from smoke inhalation

The aim of this present study was to evaluate the effect of solid lipid nanoparticles (SLN) containing carvacrol over the lung damage of airway smoke inhalation. The study was conducted with 30 rats subjected to smoke inhalation and divided into 5 groups such as, normal control, negative control, ox...

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Bibliographic Details
Published in:	Naunyn-Schmiedeberg's archives of pharmacology Vol. 393; no. 3; pp. 445 - 455
Main Authors:	Carvalho, Fernanda O., Silva, Érika R., Nunes, Paula S., Felipe, Fernanda A., Ramos, Karen P. P., Ferreira, Luiz Augusto S., Lima, Viviane N. B., Shanmugam, Saravanan, Oliveira, Alan Santos, Guterres, Sílvia S., Camargo, Enilton A., Cravalho Olivera, Tassia Virginia, de Albuquerque Júnior, Ricardo Luiz C., de Lucca Junior, Waldecy, Quintans-Júnior, Lucindo José, Araújo, Adriano A. S.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-03-2020 Springer Nature B.V
Subjects:	Administration, Inhalation Animals Biomedical and Life Sciences Biomedicine Carvacrol Cymenes - administration & dosage Cymenes - chemistry Drug Carriers - administration & dosage Drug Carriers - chemistry Emphysema Female Inhalation Larynx Lipids Lung Injury - drug therapy Lung Injury - metabolism Lungs Malondialdehyde Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Neurosciences Original Article Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Oxygen Peroxidase Pharmacology/Toxicology Random Allocation Rats Rats, Wistar Smoke Smoke inhalation Smoke Inhalation Injury - drug therapy Smoke Inhalation Injury - metabolism Trachea Natural product Carvacrol Smoke Solid lipid nanoparticle Lung injury Inhalation
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Summary:	The aim of this present study was to evaluate the effect of solid lipid nanoparticles (SLN) containing carvacrol over the lung damage of airway smoke inhalation. The study was conducted with 30 rats subjected to smoke inhalation and divided into 5 groups such as, normal control, negative control, oxygen group, SLN alone, and SLN+CARV group. The animals were sacrificed 24 h after the induction of inhalation injury further, the tissues of larynx, trachea, and lungs were collected for the histological, hematological, myeloperoxidase, and malondialdehyde analysis. The obtained results showed that treatment with CARV+SLN minimized the inhalation injury, since it reduced malondialdehyde significantly, when compared to the negative control group and minimized the histological changes which proves the absence of pulmonary emphysema and exudate in laryngeal and tracheal lumen in the CARV+SLN-treated group. Meanwhile, the presence of lesion with chronic characteristics was observed in the negative control and oxygen groups. It is suggested that the SLN containing carvacrol minimized oxidative stress and histological damages generated from smoke inhalation in rodents.
ISSN:	0028-1298 1432-1912
DOI:	10.1007/s00210-019-01731-1