Panniculitis-an unusual cutaneous manifestation of systemic sclerosis

Systemic sclerosis (SSc) is an autoimmune systemic disease characterized by small vessel involvement that leads to tissue ischemia and fibroblast stimulation resulting in accumulation of collagen (fibrosis) in the skin and internal organs. Lipomembranous panniculitis is a peculiar type of fat necros...

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Bibliographic Details
Published in:	Journal of cutaneous pathology Vol. 37; no. 11; pp. 1170 - 1173
Main Authors:	Almeida, MSTM, Lima, SCB, Carvalho, LL, Almeida, JVM, Santos, LG, Rolim, JRA, Rocha, TE
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-11-2010 Wiley-Blackwell
Subjects:	Adult Biological and medical sciences Dermatology Female Humans Medical sciences Panniculitis - etiology Panniculitis - pathology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Scleroderma, Systemic - complications Scleroderma, Systemic - pathology Skin - pathology Skin involvement in other diseases. Miscellaneous. General aspects Immunopathology Connective tissue disease Anatomic pathology Skin disease Dermatology Systemic disease Panniculitis Autoimmune disease Adipose tissue disorders Scleroderma
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Summary:	Systemic sclerosis (SSc) is an autoimmune systemic disease characterized by small vessel involvement that leads to tissue ischemia and fibroblast stimulation resulting in accumulation of collagen (fibrosis) in the skin and internal organs. Lipomembranous panniculitis is a peculiar type of fat necrosis and has been reported with clinical conditions, commonly with peripheral vascular diseases. We describe a case of a 43‐year‐old woman with SSc manifestations, who presented with black scaly skin plaques, associated with thickening of the subcutaneous fat tissue, on the lateral surface of her thighs, her calves, gluteal area and lower abdomen. Biopsy revealed lipomembranous panniculitis. Lipomembranous changes have been seen in connective tissue disorders such as lupus profundus, morphea, systemic sclerosis and panniculitis associated with dermatomyositis, but rarely in thighs, calves, gluteal area and lower abdomen. Almeida MSTM, Lima SCB, Carvalho LL, Almeida JVM, Santos LG, Rolim JRA, Rocha TE. Panniculitis–An unusual cutaneous manifestation of systemic sclerosis.
Bibliography:	ArticleID:CUP1356 ark:/67375/WNG-JLN3TLWR-V istex:85BF4334FBBF09655E12CAD91EDC339A0E28AAD3 ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0303-6987 1600-0560
DOI:	10.1111/j.1600-0560.2009.01356.x