Paracoccidioidomycosis in a western Brazilian Amazon State: clinical-epidemiologic profile and spatial distribution of the disease

Paracoccidioidomycosis (PCM) is a systemic infection caused by the fungus Paracoccidioides brasiliensis. PCM is considered one of the most important systemic mycoses in Latin America. This is a clinical, epidemiological, retrospective, quantitative study of PCM cases in patients attending the Nation...

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Bibliographic Details
Published in:	Revista da Sociedade Brasileira de Medicina Tropical Vol. 47; no. 1; pp. 63 - 68
Main Authors:	Vieira, Gabriel de Deus, Alves, Thaianne da Cunha, Lima, Sônia Maria Dias de, Camargo, Luís Marcelo Aranha, Sousa, Camila Maciel de
Format:	Journal Article
Language:	English
Published:	Brazil Sociedade Brasileira de Medicina Tropical 01-01-2014 Sociedade Brasileira de Medicina Tropical - SBMT Sociedade Brasileira de Medicina Tropical (SBMT)
Subjects:	Adolescent Adult Age Distribution Aged Aged, 80 and over Antifungal Agents - therapeutic use Brazil - epidemiology Child Child, Preschool Epidemiology Female Fungal infection Fungal infections Humans Male Middle Aged Paracoccidioidomycosis Paracoccidioidomycosis - drug therapy Paracoccidioidomycosis - epidemiology Paracoccidioidomycosis - mortality Quantitative research Retrospective Studies Socioeconomic Factors Space-Time Clustering Spatial distribution Topography, Medical Tropical diseases TROPICAL MEDICINE Young Adult Brazil Paracoccidioidomycosis Epidemiology Fungal infection
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Summary:	Paracoccidioidomycosis (PCM) is a systemic infection caused by the fungus Paracoccidioides brasiliensis. PCM is considered one of the most important systemic mycoses in Latin America. This is a clinical, epidemiological, retrospective, quantitative study of PCM cases in patients attending the National Health Service in the State of Rondônia in 1997-2012. The examined variables included sex, age group, year of diagnosis, education level, profession, place of residence, diagnostic test, prior treatment, medication used, comorbidities and case progress. During the study period, 2,163 PCM cases were registered in Rondônia, and the mean annual incidence was 9.4/100,000 people. The municipalities with the highest rates were located in the southeastern region of Rondônia, and the towns of Pimenteiras do Oeste and Espigão do Oeste had the highest rates in the state, which were 39.1/100,000 and 37.4/100,000 people, respectively. Among all cases, 90.2% and 9.8% were observed in men and women, respectively, and most cases (58.2%) were observed in patients aged between 40 and 59 years. Itraconazole was used to treat 91.6% (1,771) of cases, followed by sulfamethoxazole in combination with trimethoprim (4.4% [85] of cases). One hundred thirty-one (6%) patients died. The State of Rondônia has a high incidence of PCM, and the municipalities in the southeastern region of the state were found to have the highest incidence rates of this disease. Our findings suggest that Rondônia is the state in the northern region with the highest mortality rate for PCM.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0037-8682 1678-9849 1678-9849 0037-8682
DOI:	10.1590/0037-8682-0225-2013