Antimicrobial efficacy of chlorhexidine and calcium hydroxide/camphorated paramonochlorophenol on infected primary molars: a split-mouth randomized clinical trial

To compare via a split-mouth randomized clinical trial the efficacy of 1% chlorhexidine gel, calcium hydroxide/camphorated paramonochlorophenol (Callen PMCC), and a one-visit endodontic treatment against mutans streptococci and anaerobic bacteria found in primary molars with necrotic pulps and to as...

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Bibliographic Details
Published in:	Quintessence international (Berlin, Germany : 1985) Vol. 44; no. 2; p. 113
Main Authors:	Lima, Ramille Arújo, Carvalho, Cibele Barreto, Ribeiro, Thyciana Rodrigues, Fonteles, Cristiane Sá
Format:	Journal Article
Language:	English
Published:	Germany 01-02-2013
Subjects:	Anti-Infective Agents, Local - therapeutic use Bacteria, Anaerobic - drug effects Bacterial Load - drug effects Calcium Hydroxide - therapeutic use Camphor - therapeutic use Child Child, Preschool Chlorhexidine - therapeutic use Chlorophenols - therapeutic use Crowns Dental Fistula - therapy Dental Pulp Cavity - microbiology Dental Pulp Necrosis - microbiology Dental Pulp Necrosis - therapy Drug Combinations Follow-Up Studies Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Humans Molar - microbiology Periodontal Abscess - therapy Root Canal Filling Materials - therapeutic use Root Canal Irrigants - therapeutic use Root Canal Preparation - methods Root Canal Therapy - methods Streptococcus mutans - drug effects Tooth, Deciduous - microbiology Treatment Outcome
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Summary:	To compare via a split-mouth randomized clinical trial the efficacy of 1% chlorhexidine gel, calcium hydroxide/camphorated paramonochlorophenol (Callen PMCC), and a one-visit endodontic treatment against mutans streptococci and anaerobic bacteria found in primary molars with necrotic pulps and to assess clinical success rates after 12 months. Pre- and posttreatment intracanal samples were collected from 37 teeth (from 21 children) for analysis of the number of mutans streptococci and anaerobic bacteria. Clinical and radiographic criteria were analyzed to determine treatment outcome. Chlorhexidine gel significantly reduced mutans streptococci levels (P = .010), whereas Callen PMCC significantly reduced the levels of anaerobic bacteria (P = .002). No differences in the reduction of mutans streptococci (P = .187) and anaerobes (P = .564) were observed between groups. The clinical success rates were 85.71% (Callen PMCC), 78.57% (chlorexidine gel), and 77.77% (one-visit treatment). Teeth treated with Callen PMCC presented the highest clinical success rate. The 1% chlorhexidine gel, as well as calcium hydroxide/camphorated paramonochlorophenol, presented limited efficacy in reducing bacteria from necrotic primary root canals.
ISSN:	1936-7163
DOI:	10.3290/j.qi.a28932