Search Results - "Lima, Rafael Guimaraes"
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Meta-analysis and time series modeling allow a systematic review of primary HIV-1 drug-resistant prevalence in Latin America and Caribbean
Published in Current HIV research (01-01-2015)“…Here we review the prevalence of HIV-1 primary drug resistance in Latin America and Caribbean using meta-analysis as well as time-series modeling. We also…”
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2
Fequency distribution of HLA DQ2 and DQ8 in celiac patients and first-degree relatives in Recife, northeastern Brazil
Published in Clinics (São Paulo, Brazil) (01-01-2011)“…The aim of this study was to evaluate the frequencies of the HLA genotypes DQ2 and DQ8 and the alleles A1*05, A1*0201, B1*0201 and B1*0302 in individuals with…”
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Thymic Exhaustion and Increased Immune Activation Are the Main Mechanisms Involved in Impaired Immunological Recovery of HIV-Positive Patients under ART
Published in Viruses (01-02-2023)“…Decades of studies in antiretroviral therapy (ART) have passed, and the mechanisms that determine impaired immunological recovery in HIV-positive patients…”
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MicroRNA-Related Polymorphisms in Infectious Diseases-Tiny Changes With a Huge Impact on Viral Infections and Potential Clinical Applications
Published in Frontiers in immunology (14-06-2018)“…MicroRNAs (miRNAs) are single-stranded sequences of non-coding RNA with approximately 22 nucleotides that act posttranscriptionally on gene expression. miRNAs…”
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Dendritic Cell-Based Immunotherapies to Fight HIV: How Far from a Success Story? A Systematic Review and Meta-Analysis
Published in International journal of molecular sciences (01-12-2016)“…The scientific community still faces the challenge of developing strategies to cure HIV-1. One of these pursued strategies is the development of…”
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HIV-1 Infection Transcriptomics: Meta-Analysis of CD4+ T Cells Gene Expression Profiles
Published in Viruses (04-02-2021)“…HIV-1 infection elicits a complex dynamic of the expression various host genes. High throughput sequencing added an expressive amount of information regarding…”
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Lopinavir/Ritonavir Treatment Induces Oxidative Stress and Caspaseindependent Apoptosis in Human Glioblastoma U-87 MG Cell Line
Published in Current HIV research (2018)“…Lopinavir and Ritonavir (LPV/r) treatment is widely used to prevent HIV mother-to-child transmission. Nevertheless, studies related to the impact of these…”
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HIV-Induced Thymic Insufficiency and Aging-Related Immunosenescence on Immune Reconstitution in ART-Treated Patients
Published in Vaccines (Basel) (01-06-2024)“…The mechanisms underlying unsatisfactory immune reconstitution in HIV-1 positive patients under ART have not been fully elucidated, even after years of…”
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Increased risk of dizziness in human immunodeficiency virus‐infected patients taking zidovudine and efavirenz combination: a Brazilian cohort study
Published in Journal of pharmacy and pharmacology (01-05-2020)“…Objectives Neuropsychiatric adverse effects (NPAE) related to efavirenz, mainly dizziness, is detrimental to human immunodeficiency virus (HIV) treatment. Our…”
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Clinical-Epidemiological Characteristics and IFITM-3 (rs12252) Variant Involvement in HIV-1 Mother-to-Children Transmission Susceptibility in a Brazilian Population
Published in Life (Basel, Switzerland) (31-01-2023)“…Mother-to-children transmission (MTCT) is the main infection route for HIV-1 in children, and may occur during pregnancy, delivery, and/or postpartum. It is a…”
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HLA-C Single Nucleotide Polymorphism Associated with Increased Viral Load Level in HIV-1 Infected Individuals from Northeast Brazil
Published in Current HIV research (01-07-2017)“…Genetic variations in Human leukocyte antigen C (HLA-C), Zinc ribbon domain containing 1 (ZNRD1) and its antisense RNA (ZNRD1-AS1) genes are known to influence…”
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NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection
Published in Memórias do Instituto Oswaldo Cruz (01-11-2014)“…Inter-individual heterogeneity in the response to human T-lymphotropic virus 1 (HTLV-1) infection has been partially attributed to host genetic background. The…”
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CUL5 and APOBEC3G Polymorphisms are Partially Implicated in HIV-1 Infection and Antiretroviral Therapy in a Brazilian Population
Published in Current HIV research (01-07-2017)“…Host restriction factors are cellular proteins able to diminish or block viral replication in a cell-specific way. We evaluated the distribution of single…”
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Principles and applications of polymerase chain reaction in medical diagnostic fields: a review
Published in Brazilian journal of microbiology (01-01-2009)“…Recent developments in molecular methods have revolutionized the detection and characterization of microorganisms in a broad range of medical diagnostic…”
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Chemokines SNPs in HIV-1+ Patients and Healthy Controls from Northeast Brazil: Association with Protection against HIV-1 Infection
Published in Current HIV research (01-01-2016)“…HIV-1 virus is known to infect the host mainly through CD4+ T-lymphocyte cells, by interactions among the viral envelope proteins, CD4 receptor and HIV-1…”
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Hydrothermal alteration, mineralization and fluid inclusions in the Pista and Fofão prospects: implications for the genetic model of the Coringa polymetallic deposit, SE Tapajós Mineral Province, Amazonian Craton, Brazil
Published in Journal of the Geological Survey of Brazil (01-04-2020)“…Pista and Fofão are a prospect located near the main orebodies of the Coringa polymetallic deposit, in southeastern Tapajós Mineral Province of the Amazonian…”
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Vitamin D receptor (VDR) gene polymorphisms and age onset in type 1 diabetes mellitus
Published in Autoimmunity (Chur, Switzerland) (01-09-2013)“…Abstract Vitamin D receptor is a mediator of immune responses through the action of vitamin D, which is capable of regulate the insulin secretion by the…”
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DC-SIGN polymorphisms are associated to type 1 diabetes mellitus
Published in Immunobiology (1979) (01-11-2014)“…Abstract Type I diabetes mellitus (T1DM) is an autoimmune disorder featured by raised glucoses levels. It has been hypothesised that raised glucose levels in…”
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Immunological recovery failure in cART‐treated HIV‐positive patients is associated with reduced thymic output and RTE CD4+ T cell death by pyroptosis
Published in Journal of leukocyte biology (01-01-2020)“…Despite more than three decades of studies and advances in combination antiretroviral therapy (cART) against human immunodeficiency virus (HIV), the mechanisms…”
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CCR5 genotype and pre-treatment CD4+ T-cell count influence immunological recovery of HIV-positive patients during antiretroviral therapy
Published in Gene (30-05-2020)“…•Sociodemographic, clinical and genetic data in immunological recovery were investigated.•A significant trend between lower CD4+ T-cell in the groups was…”
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