Cladia aggregata (lichen) from Brazilian northeast: chemical characterization and antimicrobial activity

The chemical composition and antimicrobial activity of the Cladia aggregata (Sw.) Nyl. were evaluated. Barbatic acid, depside obtained from C. aggregata, was spectroscopically analyzed and tested, as well as organic extracts. The extracts and purified substance were tested against four Staphylococcu...

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Bibliographic Details
Published in:	Brazilian archives of biology and technology Vol. 53; no. 1; pp. 115 - 122
Main Authors:	Martins, Mônica Cristina Barroso, Lima, Marcio James Gonçalves de, Silva, Flávia Pereira, Azevedo-Ximenes, Eulália, Silva, Nicácio Henrique da(Universidade Federal de Pernambuco Centro de Ciências Biológicas Departamento de Bioquímica), Pereira, Eugênia Cristina(Universidade Federal de Pernambuco Centro de Filosofia e Ciências Humanas Departamento de Ciências Geográficas)
Format:	Journal Article
Language:	English
Published:	Tecpar 01-02-2010 Instituto de Tecnologia do Paraná (Tecpar)
Subjects:	antimicrobial activity barbatic acid Cladia aggregata
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Summary:	The chemical composition and antimicrobial activity of the Cladia aggregata (Sw.) Nyl. were evaluated. Barbatic acid, depside obtained from C. aggregata, was spectroscopically analyzed and tested, as well as organic extracts. The extracts and purified substance were tested against four Staphylococcus aureus multi-resistant strains. The structure of barbatic acid was confirmed through NMR (¹H; 13C) and elemental ® analysis. Biochromatographic assays showed action of this compound, along with other substances contained in organic extracts, suggesting a synergic action, MIC assays placed barbatic acid in the same level of inhibition to other studied lichen substances. A composição química e a atividade antimicrobiana da Cladia aggregata (Sw.) Nyl. foram avaliadas. O ácido barbático, um depsideo obtido da C. aggregata, foi espectroscopicamente analisado e testado, bem como o extrato orgânico. o extrato e a substância purificada foram testadas contra 4 linhagens de Staphylococcus aureus multi resistentes. A estrutura do ácido barbático foi confirmada através de ensaios de CCD, CLAE, IV, RMN (¹H;13C), UV e analise elementar (r). O biocromatograma mostrou a ação deste composto junto com outras substâncias contidas no extrato orgânico, sugerindo a ação sinérgica, a CMI do ácido barbático mostrou o mesmo nível de inibição de outras substâncias liquênicas.
Bibliography:	http://www.scielo.br/scielo.php?pid=S1516-89132010000100015&script=sci_abstract&tlng=pt
ISSN:	1516-8913 1516-8913 1678-4324
DOI:	10.1590/S1516-89132010000100015