Search Results - "Lima, Lídia M"

Synthesis, trypanocidal activity and docking studies of novel quinoxaline- N-acylhydrazones, designed as cruzain inhibitors candidates by Romeiro, Nelilma C., Aguirre, Gabriela, Hernández, Paola, González, Mercedes, Cerecetto, Hugo, Aldana, Ignacio, Pérez-Silanes, Silvia, Monge, Antonio, Barreiro, Eliezer J., Lima, Lídia M.

“…In this paper, we report the structural design, synthesis, trypanocidal activity and docking studies of novel quinoxaline- N-acylhydrazone (NAH) derivatives,…”
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2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties by de Oliveira, Daniela R, Maia, Rodolfo C, de Carvalho França, Patrícia R, Fernandes, Patrícia D, Barbosa, Gisele, Lima, Lídia M, Fraga, Carlos A Manssour

“…Among the most recent proposals regarding the mechanism of action of dipyrone, the modulation of cannabinoid receptors CB and CB appears to be a promising…”
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Design, synthesis and in vitro trypanocidal and leishmanicidal activities of novel semicarbazone derivatives by Alves, Marina A., de Queiroz, Aline C., Alexandre-Moreira, Magna Suzana, Varela, Javier, Cerecetto, Hugo, González, Mercedes, Doriguetto, Antonio C., Landre, Iara M., Barreiro, Eliezer J., Lima, Lídia M.

“…Trypanosomatids are protozoan parasites that cause various diseases in human, such as leishmaniasis, Chagas disease and sleeping sickness. The highly syntenic…”
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Synthesis and anti-platelet activity of novel arylsulfonate–acylhydrazone derivatives, designed as antithrombotic candidates by Lima, Lídia M., Frattani, Flávia S., dos Santos, Jean L., Castro, Helena C., Fraga, Carlos Alberto M., Zingali, Russolina B., Barreiro, Eliezer J.

“…In this work, we describe a new class of promising anti-platelet drug candidates with significant antithrombotic activity in vivo. This new series of compounds…”
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Synthesis and anti-inflammatory activity of phthalimide derivatives, designed as new thalidomide analogues by Lima, Lı́dia M, Castro, Paulo, Machado, Alexandre L, Fraga, Carlos Alberto M, Lugnier, Claire, de Moraes, Vera Lúcia Gonçalves, Barreiro, Eliezer J

“…This paper describes the synthesis and anti-inflammatory activity of new N-phenyl-phthalimide sulfonamides ( 3a– e) and the isosters N-phenyl-phthalimide…”
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Docking, synthesis and anti-diabetic activity of novel sulfonylhydrazone derivatives designed as PPAR-gamma agonists by Zapata-Sudo, Gisele, Lima, Lídia M, Pereira, Sharlene L, Trachez, Margarete M, da Costa, Filipe P, Souza, Beatriz J, Monteiro, Carlos E S, Romeiro, Nelilma C, D'Andrea, Éverton D, Sudo, Roberto T, Barreiro, Eliezer J

“…Diabetes is a metabolic disorder characterized by hyperglycemia. When not properly controlled, complications include neuropathy, coronary artery disease, and…”
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N-Acylhydrazones as drugs by Thota, Sreekanth, Rodrigues, Daniel A., Pinheiro, Pedro de Sena Murteira, Lima, Lídia M., Fraga, Carlos A.M., Barreiro, Eliezer J.

“…[Display omitted] •N-Acylhydrazone (NAH) motif in Drug Design and Medicinal Chemistry.•NAH-related approved drugs.•N-Acylhydrazone motif scaffolds in clinical…”
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Discovery of naphthyl‐N‐acylhydrazone p38α MAPK inhibitors with in vivo anti‐inflammatory and anti‐TNF‐α activity by Freitas, Rosana H. C. N., Cordeiro, Natália M., Carvalho, Patrícia R., Alves, Marina A., Guedes, Isabella A., Valerio, Tayna S., Dardenne, Laurent E., Lima, Lídia M., Barreiro, Eliezer J., Fernandes, Patrícia D., Fraga, Carlos A. M.

“…Protein kinases constitute attractive therapeutic targets for development of new prototypes to treat different chronic diseases. Several available drugs, like…”
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Comparative chemical and biological hydrolytic stability of homologous esters and isosteres by de Souza, Hygor M. R., Guedes, Jéssica S., Freitas, Rosana H. C. N., Gelves, Luis G. V., Fokoue, Harold H., Sant'Anna, Carlos Mauricio R., Barreiro, Eliezer J., Lima, Lidia M.

“…Esters are one of the major functional groups present in the structures of prodrugs and bioactive compounds. Their presence is often associated with hydrolytic…”
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Carbamoyl- N -aryl-imine-urea: a new framework to obtain a putative leishmanicidal drug-candidate by Alves, Marina A, de Queiroz, Aline C, Leite, Anderson Brandão, Martins, Felipe T, Doriguetto, Antonio C, Barreiro, Eliezer J, Alexandre-Moreira, Magna S, Lima, Lídia M

“…Leishmaniasis is a neglected parasitic disease, and current treatment includes limitations of toxicity, variable efficacy, high costs and inconvenient doses…”
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LASSBio-468: a new achiral thalidomide analogue which modulates TNF-α and NO production and inhibits endotoxic shock and arthritis in an animal model by Alexandre-Moreira, Magna S., Takiya, Christina M., de Arruda, Luciana B., Pascarelli, Bernardo, Gomes, Raquel N., Castro Faria Neto, Hugo C., Lima, Lídia M., Barreiro, Eliezer J.

“…As part of a program researching the synthesis and immunopharmacological evaluation of novel synthetic compounds, we have described the immune modulatory…”
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Structural and functional characterization of a multifunctional alanine-rich peptide analogue from Pleuronectes americanus by Migliolo, Ludovico, Silva, Osmar N, Silva, Paula A, Costa, Maysa P, Costa, Carolina R, Nolasco, Diego O, Barbosa, João A R G, Silva, Maria R R, Bemquerer, Marcelo P, Lima, Lidia M P, Romanos, Maria T V, Freitas, Sonia M, Magalhães, Beatriz S, Franco, Octavio L

“…Recently, defense peptides that are able to act against several targets have been characterized. The present work focuses on structural and functional…”
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Reduction of cardiac and renal dysfunction by new inhibitor of DPP4 in diabetic rats by Alves, Bryelle E O, de Alencar, Allan K N, Gamba, Luis E R, Trachez, Margarete M, da Silva, Jaqueline S, Araújo, Josenildo S C, Montagnoli, Tadeu L, Mendes, Luiza V P, Pimentel-Coelho, Pedro M, do M N Cunha, Valéria, Mendez-Otero, Rosalia, Oliveira, Gláucia M M, Lima, Lídia M, Barreiro, Eliezer J, Sudo, Roberto T, Zapata-Sudo, Gisele

“…Increased mortality due to type 2 diabetes mellitus (T2DM) has been associated with renal and/or cardiovascular dysfunction. Dipeptidyl dipeptidase-4…”
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Synthesis, X-ray diffraction study and pharmacological evaluation of 3-amino-4-methylthiophene-2-acylcarbohydrazones by Herrmann, Sonja, Schübel, Tabea, Costa, Fanny N, Barbosa, Maria Letícia C, Ferreira, Fabio F, Dias, Thays L M F, Araújo, Morgana V, Alexandre-Moreira, Magna S, Lima, Lídia M, Laufer, Stefan, Barreiro, Eliezer J

“…N-acylhydrazone is an interesting privileged structure that has been used in the molecular design of a myriad of bioactive compounds. In order to identify new…”
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Synthesis, Biological Evaluation, and Structure-activity Relationship of Clonazepam, Meclonazepam, and 1,4-Benzodiazepine Compounds with Schistosomicidal Activity by Menezes, Carla M. S., Rivera, Gildardo, Alves, Marina A., do Amaral, Daniel N., Thibaut, Jean Pierre B., Noël, François, Barreiro, Eliezer J., Lima, Lídia M.

“…The inherent morbidity and mortality caused by schistosomiasis is a serious public health problem in developing countries. Praziquantel is the only drug in…”
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Evaluating the prophylactic potential of the phtalimide derivative LASSBio 552 on allergen-evoked inflammation in rats by Neves, Josiane S., Lima, Lídia M., Fraga, Carlos A.M., Barreiro, Eliezer J., Miranda, Ana L.P., Diaz, Bruno L., Balduino, Alex, Siqueira, Rodrigo de Azeredo, e Silva, Patrícia M.R., Martins, Marco A.

“…A previous study showed that the novel tetrazolephtalimide derivative LASSBio 552 (2-4-[3-(1 H-1,2,3,4-tetraazol-5-yl)propoxy]phenethyl-1,3-isoindolinedione)…”
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The possible molecular evolution of sapoviruses by inter- and intra-genogroup recombination by dos Anjos, Karoline, Lima, Lidia M. P., Silva, Paula Andreia, Inoue-Nagata, Alice K., Nagata, Tatsuya

“…Sapporo virus belongs to the genus Sapovirus (family Caliciviridae ) and has a non-segmented single-stranded, positive-sense RNA genome. This virus causes…”
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Therapeutic effects of LASSBio-596 in an elastase-induced mouse model of emphysema by Padilha, Gisele A, Henriques, Isabela, Lopes-Pacheco, Miquéias, Abreu, Soraia C, Oliveira, Milena V, Morales, Marcelo M, Lima, Lidia M, Barreiro, Eliezer J, Silva, Pedro L, Xisto, Debora G, Rocco, Patricia R M

“…Emphysema is an intractable pulmonary disease characterized by an inflammatory process of the airways and lung parenchyma and ongoing remodeling process in an…”
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Synthesis, Biological Evaluation and Molecular Docking of New Benzenesulfonylhydrazone as Potential anti-Trypanosoma cruzi Agents by Elizondo-Jimenez, Silvia, Moreno-Herrera, Antonio, Reyes-Olivares, Rogelio, Dorantes-Gonzalez, Edith, Nogueda-Torres, Benjamín, Oliveira, Eduardo A Gamosa de, Romeiro, Nelilma C, Lima, Lidia M, Palos, Isidro, Rivera, Gildardo

“…Chagas disease is a public health problem caused by Trypanosoma cruzi. Cruzain is a pharmacological target for designing a new drug against this parasite…”
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Revisiting Nitroaromatic Drugs: Mechanisms of Bioactivation, Metabolism and Toxicity and Methods to Synthesize Nitroaromatic Fragments by Abreu, Saulo, Gelves, Luis Gabriel, Barreiro, Eliezer, Lima, Lídia

“…Nitroaromatic drugs represent an important class of therapeutic agents, endowed with different pharmacological properties such as antibacterial, antiprotozoal,…”
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