Nanostructures for Delivery of Flavonoids with Antibacterial Potential against Klebsiella pneumoniae

Flavonoids are secondary metabolites that exhibit remarkable biological activities, including antimicrobial properties against , a pathogen responsible for several serious nosocomial infections. However, oral administration of these compounds faces considerable challenges, such as low bioavailabilit...

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Bibliographic Details
Published in:	Antibiotics (Basel) Vol. 13; no. 9; p. 844
Main Authors:	Macêdo, Hanne Lazla Rafael de Queiroz, de Oliveira, Lara Limeira, de Oliveira, David Nattan, Lima, Karitas Farias Alves, Cavalcanti, Isabella Macário Ferro, Campos, Luís André de Almeida
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 05-09-2024 MDPI
Subjects:	Addition polymerization Antibacterial agents Antibiotics Antimicrobial agents Bacterial pneumonia Bioavailability Biofilms Bioflavonoids Biological properties Biosynthesis Chemical compounds Chemical properties Composition Dosage and administration Drug therapy Encapsulation Flavones Flavonoids Free radicals Gram-negative bacteria Health aspects Herbal medicine Infections Isoflavones Klebsiella Klebsiella infections Klebsiella pneumoniae Literature reviews Medical prognosis Metabolism Metabolites Micelles Microbiota (Symbiotic organisms) Nanoparticles Nanotechnology natural products Nosocomial infection Oral administration Pathogens Patient compliance Pharmacology Phytochemicals Pneumonia Reagents Review Secondary metabolites Sewer systems Side effects Structure Urinary tract infections Viral infections Brazil nanotechnology natural products Gram-negative bacteria
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Summary:	Flavonoids are secondary metabolites that exhibit remarkable biological activities, including antimicrobial properties against , a pathogen responsible for several serious nosocomial infections. However, oral administration of these compounds faces considerable challenges, such as low bioavailability and chemical instability. Thus, the encapsulation of flavonoids in nanosystems emerges as a promising strategy to mitigate these limitations, offering protection against degradation; greater solubility; and, in some cases, controlled and targeted release. Different types of nanocarriers, such as polymeric nanoparticles, liposomes, and polymeric micelles, among others, have shown potential to increase the antimicrobial efficacy of flavonoids by reducing the therapeutic dose required and minimizing side effects. In addition, advances in nanotechnology enable co-encapsulation with other therapeutic agents and the development of systems responsive to more specific stimuli, optimizing treatment. In this context, the present article provides an updated review of the literature on flavonoids and the main nanocarriers used for delivering flavonoids with antibacterial properties against
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	2079-6382 2079-6382
DOI:	10.3390/antibiotics13090844