Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion

Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion

Objective. The inhalation anesthetic sevoflurane has presented numerous biological activities, including anti-inflammatory properties and protective effects against tissue ischemic injury. This study investigated the metabolic, hemodynamic, and inflammatory effects of sevoflurane pre- and postcondit...

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Published in:Gastroenterology research and practice Vol. 2019; no. 2019; pp. 1 - 7
Main Authors: Abdo, Emilio Elias, D'Albuquerque, Luiz Augusto Carneiro, Galvao, Flavio H. F., Mendes, Camilla Oliveira, Lima, Jonathan Augusto Venceslau, Tatebe, Eduardo Ryoiti, Nakatani, Mauro, Coelho, Ana Maria Mendonça, Lanchotte, Cinthia, Rocha-Filho, Joel Avancini, Figueira, Estela Regina Ramos, de Araujo, Bruno Camargo Rocha Paim
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2019
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Analysis
Anesthesia
Anesthesiology
Anesthetics
Carotid arteries
Cytokines
Enflurane
Hypoxia
Ischemia
Laboratory animals
Liver
Liver diseases
Metabolism
Rodents
Sevoflurane
Surgery
Veins & arteries
Ventilation
Brazil
United States > US
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Summary:Objective. The inhalation anesthetic sevoflurane has presented numerous biological activities, including anti-inflammatory properties and protective effects against tissue ischemic injury. This study investigated the metabolic, hemodynamic, and inflammatory effects of sevoflurane pre- and postconditioning for short periods in the rescue of liver ischemia-reperfusion (IR) injury using a rat model. Materials and Methods. Twenty Wistar rats were divided into four groups: sham group, control ischemia group (partial warm liver ischemia for 45 min followed by 4 h of reperfusion), SPC group (administration of sevoflurane 2.5% for 15 min with 5 min of washout before liver IR), and SPPoC group (administration of sevoflurane 2.5% for 15 min before ischemia and 20 min during reperfusion). Results. All animals showed a decrease in the mean arterial pressure (MAP) and portal vein blood flow during ischemia. After 4 h of reperfusion, only the SPPoC group had MAP recovery. In both the SPC and SPPoC groups, there was a decrease in the ALT level and an increase in the bicarbonate and potassium serum levels. Only the SPPoC group showed an increase in the arterial blood ionized calcium level and a decrease in the IL-6 level after liver reperfusion. Therefore, this study demonstrated that sevoflurane preconditioning reduces hepatocellular injury and acid-base imbalance in liver ischemia. Furthermore, sevoflurane postconditioning promoted systemic hemodynamic recovery with a decrease in inflammatory response.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Academic Editor: Erica Novo
ISSN:1687-6121
1687-630X
DOI:10.1155/2019/5758984