Search Results - "Lima, John J."

Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine by El Rouby, Nihal, Lima, John J, Johnson, Julie A

“…Proton Pump inhibitors (PPIs) are commonly used for a variety of acid related disorders. Despite the overall effectiveness and safety profile of PPIs, some…”
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing by Lima, John J., Thomas, Cameron D., Barbarino, Julia, Desta, Zeruesenay, Van Driest, Sara L., El Rouby, Nihal, Johnson, Julie A., Cavallari, Larisa H., Shakhnovich, Valentina, Thacker, David L., Scott, Stuart A., Schwab, Matthias, Uppugunduri, Chakradhara Rao S., Formea, Christine M., Franciosi, James P., Sangkuhl, Katrin, Gaedigk, Andrea, Klein, Teri E., Gammal, Roseann S., Furuta, Takahisa

“…Proton pump inhibitors (PPIs) are widely used for acid suppression in the treatment and prevention of many conditions, including gastroesophageal reflux…”
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Being Overweight or Obese and the Development of Asthma by Lang, Jason E, Bunnell, H Timothy, Hossain, Md Jobayer, Wysocki, Tim, Lima, John J, Finkel, Terri H, Bacharier, Leonard, Dempsey, Amanda, Sarzynski, Lisa, Test, Matthew, Forrest, Christopher B

“…Adult obesity is linked to asthma cases and is estimated to lead to 250 000 new cases yearly. Similar incidence and attributable risk (AR) estimates have not…”
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Overweight children report qualitatively distinct asthma symptoms: Analysis of validated symptom measures by Lang, Jason E., MD, MPH, Hossain, Md Jobayer, PhD, Lima, John J., PharmD

“…Background Past studies of asthma in overweight/obese children have been inconsistent. The reason overweight/obese children commonly report worse asthma…”
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Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population by Tamari, Mayumi, Hirota, Tomomitsu, Takahashi, Atsushi, Kubo, Michiaki, Tsunoda, Tatsuhiko, Tomita, Kaori, Doi, Satoru, Fujita, Kimie, Miyatake, Akihiko, Enomoto, Tadao, Miyagawa, Takehiko, Adachi, Mitsuru, Tanaka, Hiroshi, Niimi, Akio, Matsumoto, Hisako, Ito, Isao, Masuko, Hironori, Sakamoto, Tohru, Hizawa, Nobuyuki, Taniguchi, Masami, Lima, John J, Irvin, Charles G, Peters, Stephen P, Himes, Blanca E, Litonjua, Augusto A, Tantisira, Kelan G, Weiss, Scott T, Kamatani, Naoyuki, Nakamura, Yusuke

“…Bronchial asthma is a common inflammatory disease caused by the interaction of genetic and environmental factors. Through a genome-wide association study and a…”
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Income is an independent risk factor for worse asthma outcomes by Cardet, Juan Carlos, MD, Louisias, Margee, MD, MPH, King, Tonya S., PhD, Castro, Mario, MD, MPH, Codispoti, Christopher D., MD, PhD, Dunn, Ryan, MD, Engle, Linda, BS, Giles, B. Louise, MD, Holguin, Fernando, MD, MPH, Lima, John J., PharmD, Long, Dayna, MD, Lugogo, Njira, MD, Nyenhuis, Sharmilee, MD, Ortega, Victor E., MD, PhD, Ramratnam, Sima, MD, MPH, Wechsler, Michael E., MD, MMSc, Israel, Elliot, MD, Phipatanakul, Wanda, MD, MS

“…Abstract Background Socioeconomic status (SES) is associated with asthma morbidity in observational studies but the factors underlying this association are…”
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Asthma in the elderly: Current understanding and future research needs—a report of a National Institute on Aging (NIA) workshop by Hanania, Nicola A., MD, MS, (Co-chair), King, Monroe J., DO, (Chair), Braman, Sidney S., MD, Saltoun, Carol, MD, Wise, Robert A., MD, Enright, Paul, MD, Falsey, Ann R., MD, Mathur, Sameer K., MD, PhD, Ramsdell, Joe W., MD, Rogers, Linda, MD, Stempel, David A., MD, Lima, John J., PharmD, Fish, James E., MD, Wilson, Sandra R., PhD, Boyd, Cynthia, MD, MPH, Patel, Kushang V., PhD, Irvin, Charles G., PhD, Yawn, Barbara P., MD, MSc, Halm, Ethan A., MD, MPH, Wasserman, Stephen I., MD, Sands, Mark F., MD, Ershler, William B., MD, Ledford, Dennis K., MD

“…Asthma in the elderly is underdiagnosed and undertreated, and there is a paucity of knowledge on the subject. The National Institute on Aging convened this…”
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Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids by Park, Heung-Woo, MD, PhD, Dahlin, Amber, PhD, MMSc, Tse, Szeman, MDCM, MPH, Duan, Qing Ling, PhD, Schuemann, Brooke, BS, Martinez, Fernando D., MD, Peters, Stephen P., MD, PhD, Szefler, Stanley J., MD, Lima, John J., PharmD, Kubo, Michiaki, MD, PhD, Tamari, Mayumi, MD, PhD, Tantisira, Kelan G., MD, MPH

“…Background To date, genome-wide association studies (GWASs) of inhaled corticosteroid (ICS) response in asthmatic patients have focused primarily on lung…”
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Genome-Wide Association Study Identifies Novel Pharmacogenomic Loci For Therapeutic Response to Montelukast in Asthma by Dahlin, Amber, Litonjua, Augusto, Lima, John J, Tamari, Mayumi, Kubo, Michiaki, Irvin, Charles G, Peters, Stephen P, Tantisira, Kelan G

“…Genome-wide association study (GWAS) is a powerful tool to identify novel pharmacogenetic single nucleotide polymorphisms (SNPs). Leukotriene receptor…”
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Association between exhaled carbon monoxide and asthma outcomes in Peruvian children by Pereira, Amanda A., Pollard, Suzanne L., Locke, Robert, Romero, Karina, Lima, John J., Hansel, Nadia N., Checkley, William

“…Asthma prevalence continues to increase in low and middle-income countries, presenting challenges in assessing asthma control in resource-poor settings…”
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Influence of Leukotriene Pathway Polymorphisms on Response to Montelukast in Asthma by Lima, John J, Zhang, Shu, Grant, Audrey, Shao, Lianhe, Tantisira, Kelan G, Allayee, Hooman, Wang, Jianwei, Sylvester, James, Holbrook, Janet, Wise, Robert, Weiss, Scott T, Barnes, Kathleen

“…Interpatient variability in montelukast response may be related to variation in leukotriene pathway candidate genes. To determine associations between…”
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Asthma Severity, Exacerbation Risk, and Controller Treatment Burden in Underweight and Obese Children by Lang, Jason E., Hossain, Jobayer, Smith, Kareema, Lima, John J.

“…Objective. The relationship between weight status and asthma characteristics in children remains inadequately defined. Very little has been published on the…”
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Association of CYP2C19 Polymorphisms and Lansoprazole-Associated Respiratory Adverse Effects in Children by Lima, John J., PharmD, Lang, Jason E., MD, Mougey, Edward B., PhD, Blake, Kathryn B., PharmD, Gong, Yan, PhD, Holbrook, Janet T., MPH, PhD, Wise, Robert A., MD, Teague, W.G., MD

“…Objective To determine whether cytochrome P 450CYP 2C19 haplotype associates with lansoprazole-associated adverse event frequency. Study design Respiratory…”
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Free 25(OH)D concentrations are associated with atopy and lung function in children with asthma by Pollard, Suzanne L., PhD, Lima, John J., PharmD, Mougey, Edward, PhD, Romero, Karina, MD, Tarazona-Meza, Carla, RD, Tomaino, Katherine, MSPH, Guzmán, Gary Malpartida, BS, Hansel, Nadia N., MD, MPH, Checkley, William, MD, PhD

“…Abstract Background Evidence suggests free mono-hydroxyvitamin D (25[OH]D) concentrations are more strongly linked to certain outcomes than total…”
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The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics by Allayee, Hooman, Hartiala, Jaana, Lee, Won, Mehrabian, Margarete, Irvin, Charles G, Conti, David V, Lima, John J

“…Recent studies have implicated the 5-lipoxygenase/leukotriene (LT) pathway in cardiovascular disease (CVD), which may have important implications for…”
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Low cigarette smoking prevalence in peri-urban Peru: results from a population-based study of tobacco use by self-report and urine cotinine by Morgan, Brooks W, Leifheit, Kathryn M, Romero, Karina M, Gilman, Robert H, Bernabe-Ortiz, Antonio, Miranda, J Jaime, Feldman, Harold I, Lima, John J, Checkley, William

“…A recent study found lower self-reported prevalence of tobacco smoking in a peri-urban area of Lima, Peru than previously reported in urban samples. These…”
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Effect of Obesity on Clinical Presentation and Response to Treatment in Asthma by Dixon, Anne E., Shade, David M., Cohen, Rubin I., Skloot, Gwen S., Holbrook, Janet T., Smith, Lewis J., Lima, John J., Allayee, Hooman, Irvin, Charles G., Wise, Robert A.

“…Obesity is a risk factor for being diagnosed with asthma, but there is conflicting evidence on whether obesity is a risk factor for lung function abnormalities…”
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Do genetic polymorphisms alter patient response to inhaled bronchodilators? by Lima, John J

“…Short- and long-acting β agonists (SABA and LABA) are bronchodilators for treating asthma. Bronchodilator response (BDR) is quantified by measuring air expired…”
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Biologic Mechanisms of Environmental Tobacco Smoke in Children with Poorly Controlled Asthma: Results from a Multicenter Clinical Trial by Lang, Jason E., MD, Dozor, Allen J., MD, Holbrook, Janet T., PhD, MPH, Mougey, Edward, PhD, Krishnan, Sankaran, MD, Sweeten, Shawn, BS, Wise, Robert A., MD, Teague, W. Gerald, MD, Wei, Christine Y., MS, Shade, David, JD, Lima, John J., PharmD

“…Background Environmental tobacco smoke (ETS) negatively affects children with asthma. The prevalence of ETS exposure among children with poor asthma control…”
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Genomewide Association between GLCCI1 and Response to Glucocorticoid Therapy in Asthma by Tantisira, Kelan G, Lasky-Su, Jessica, Harada, Michishige, Murphy, Amy, Litonjua, Augusto A, Himes, Blanca E, Lange, Christoph, Lazarus, Stephen C, Lazarus, Ross, Sylvia, Jody, Klanderman, Barbara, Duan, Qing Ling, Qiu, Weiliang, Hirota, Tomomitsu, Martinez, Fernando D, Mauger, David, Sorkness, Christine, Szefler, Stanley, Lemanske, Robert F, Peters, Stephen P, Lima, John J, Nakamura, Yusuke, Tamari, Mayumi, Weiss, Scott T

“…Patients with asthma vary markedly in their clinical response to inhaled glucocorticoids. These investigators used a novel approach to identify a common…”
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