Search Results - "Lima, Joanna D.C.C."

Tumour‐derived transforming growth factor‐β signalling contributes to fibrosis in patients with cancer cachexia by Lima, Joanna D.C.C., Simoes, Estefania, Castro, Gabriela, Morais, Mychel Raony P.T., Matos‐Neto, Emidio M., Alves, Michele J., Pinto, Nelson I., Figueredo, Raquel G., Zorn, Telma M.T., Felipe‐Silva, Aloísio S., Tokeshi, Flavio, Otoch, José P., Alcantara, Paulo, Cabral, Fernanda J., Ferro, Emer S., Laviano, Alessandro, Seelaender, Marilia

“…Background Cachexia is a paraneoplastic syndrome related with poor prognosis. The tumour micro‐environment contributes to systemic inflammation and increased…”
Get full text

Cancer cachexia induces morphological and inflammatory changes in the intestinal mucosa by Costa, Raquel G.F., Caro, Paula L., Matos‐Neto, Emídio M., Lima, Joanna D.C.C., Radloff, Katrin, Alves, Michele J., Camargo, Rodolfo G., Pessoa, Ana Flávia M., Simoes, Estefania, Gama, Patrícia, Cara, Denise C., Silva, Aloísio S.F., O. Pereira, Welbert, Maximiano, Linda F., Alcântara, Paulo S.M., Otoch, José P., Trinchieri, Giorgio, Laviano, Alessandro, Muscaritoli, Maurizio, Seelaender, Marília

“…Background Cachexia is a multifactorial and multiorgan syndrome associated with cancer and other chronic diseases and characterized by severe involuntary body…”
Get full text

Cachexia causes time‐dependent activation of the inflammasome in the liver by Neves, Rodrigo Xavier, Yamashita, Alex S., Riccardi, Daniela M.R., Köhn‐Gaone, Julia, Camargo, Rodolfo G., Neto, Nelson I., Caetano, Daniela, Gomes, Silvio P., Santos, Felipe H., Lima, Joanna D.C.C., Batista, Miguel L., Rosa‐Neto, José Cesar, Martins De Alcântara, Paulo Sérgio, Maximiano, Linda F., Otoch, José P., Trinchieri, Giorgio, Tirnitz‐Parker, Janina E.E., Seelaender, Marília

“…Background Cachexia is a wasting syndrome associated with systemic inflammation and metabolic disruption. Detection of the early signs of the disease may…”
Get full text

Hif-2[alpha] programs oxygen chemosensitivity in chromaffin cells by Prange-Barczynska, Maria, Jones, Holly A, Sugimoto, Yoichiro, Cheng, Xiaotong, Lima, Joanna D.C.C, Ratnayaka, Indrika, Douglas, Gillian, Buckler, Keith J, Ratcliffe, Peter J, Keeley, Thomas P, Bishop, Tammie

“…The study of transcription factors that determine specialized neuronal functions has provided invaluable insights into the physiology of the nervous system…”
Get full text

Hif-2α programs oxygen chemosensitivity in chromaffin cells by Prange-Barczynska, Maria, Jones, Holly A, Sugimoto, Yoichiro, Cheng, Xiaotong, Lima, Joanna Dcc, Ratnayaka, Indrika, Douglas, Gillian, Buckler, Keith J, Ratcliffe, Peter J, Keeley, Thomas P, Bishop, Tammie

“…The study of transcription factors that determine specialized neuronal functions has provided invaluable insights into the physiology of the nervous system…”
Get full text

Human Cachexia Induces Changes in Mitochondria, Autophagy and Apoptosis in the Skeletal Muscle by de Castro, Gabriela S, Simoes, Estefania, Lima, Joanna D C C, Ortiz-Silva, Milene, Festuccia, William T, Tokeshi, Flávio, Alcântara, Paulo S, Otoch, José P, Coletti, Dario, Seelaender, Marilia

“…Cachexia is a wasting syndrome characterized by the continuous loss of skeletal muscle mass due to imbalance between protein synthesis and degradation, which…”
Get full text

Oncogenic Cell Tagging and Single-Cell Transcriptomics Reveal Cell Type-Specific and Time-Resolved Responses to Vhl Inactivation in the Kidney by Kurlekar, Samvid, Lima, Joanna D C C, Li, Ran, Lombardi, Olivia, Masson, Norma, Barros, Ayslan B, Pontecorvi, Virginia, Mole, David R, Pugh, Christopher W, Adam, Julie, Ratcliffe, Peter J

“…Defining the initial events in oncogenesis and the cellular responses they entrain, even in advance of morphologic abnormality, is a fundamental challenge in…”
Get full text

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control by Cheng, Xiaotong, Prange-Barczynska, Maria, Fielding, James W, Zhang, Minghao, Burrell, Alana L, Lima, Joanna Dcc, Eckardt, Luise, Argles, Isobel LA, Pugh, Christopher W, Buckler, Keith J, Robbins, Peter A, Hodson, Emma J, Bruick, Richard K, Collinson, Lucy M, Rastinejad, Fraydoon, Bishop, Tammie, Ratcliffe, Peter J

“…Hypoxia-inducible factor (HIF) is strikingly upregulated in many types of cancer, and there is great interest in applying inhibitors of HIF as anticancer…”
Get full text

Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma by Eckardt, Luise, Prange-Barczynska, Maria, Hodson, Emma J, Fielding, James W, Cheng, Xiaotong, Lima, Joanna D C C, Kurlekar, Samvid, Douglas, Gillian, Ratcliffe, Peter J, Bishop, Tammie

“…Despite a general role for the HIF hydroxylase system in cellular oxygen sensing and tumour hypoxia, cancer-associated mutations of genes in this pathway,…”
Get full text

COVID-19 induces more pronounced extracellular matrix deposition than other causes of ARDS by de Souza Xavier Costa, Natália, Ribeiro Júnior, Gabriel, do Nascimento, Ellen Caroline Toledo, de Brito, Jôse Mara, Antonangelo, Leila, Faria, Caroline Silvério, Monteiro, Jhonatas Sirino, Setubal, João Carlos, Pinho, João Renato Rebello, Pereira, Roberta Verciano, Seelaender, Marilia, de Castro, Gabriela Salim, Lima, Joanna D C C, de Almeida Monteiro, Renata Aparecida, Duarte-Neto, Amaro Nunes, Saldiva, Paulo Hilário Nascimento, Ferraz da Silva, Luiz Fernando, Dolhnikoff, Marisa, Mauad, Thais

“…Lung fibrosis is a major concern in severe COVID-19 patients undergoing mechanical ventilation (MV). Lung fibrosis frequency in post-COVID syndrome is highly…”
Get full text

Marked and rapid effects of pharmacological HIF-2[alpha] antagonism on hypoxic ventilatory control by Cheng, Xiaotong, Prange-Barczynska, Maria, Fielding, James W, Zhang, Minghao, Burrell, Alana L, Lima, Joanna D.C.C, Eckardt, Luise, Argles, Isobel L.A, Pugh, Christopher W, Buckler, Keith J, Robbins, Peter A, Hodson, Emma J, Bruick, Richard K, Collinson, Lucy M, Rastinejad, Fraydoon, Bishop, Tammie, Ratcliffe, Peter J

“…Hypoxia-inducible factor (HIF) is strikingly upregulated in many types of cancer, and there is great interest in applying inhibitors of HIF as anticancer…”
Get full text

Aging Aggravates Cachexia in Tumor-Bearing Mice by Geppert, Julia, Walth, Alina A, Terrón Expósito, Raúl, Kaltenecker, Doris, Morigny, Pauline, Machado, Juliano, Becker, Maike, Simoes, Estefania, Lima, Joanna D C C, Daniel, Carolin, Berriel Diaz, Mauricio, Herzig, Stephan, Seelaender, Marilia, Rohm, Maria

“…Cancer is primarily a disease of high age in humans, yet most mouse studies on cancer cachexia are conducted using young adolescent mice. Given that metabolism…”
Get full text

Systemic Inflammation in Cachexia - Is Tumor Cytokine Expression Profile the Culprit? by de Matos-Neto, Emidio M, Lima, Joanna D C C, de Pereira, Welbert O, Figuerêdo, Raquel G, Riccardi, Daniela M Dos R, Radloff, Katrin, das Neves, Rodrigo X, Camargo, Rodolfo G, Maximiano, Linda F, Tokeshi, Flávio, Otoch, José P, Goldszmid, Romina, Câmara, Niels O S, Trinchieri, Giorgio, de Alcântara, Paulo S M, Seelaender, Marília

“…Cachexia affects about 80% of gastrointestinal cancer patients. This multifactorial syndrome resulting in involuntary and continuous weight loss is accompanied…”
Get full text