Identification of plasmid IncQ1 and NTEKPC-IId harboring bla KPC-2 in isolates from Klebsiella pneumoniae infections in patients from Recife-PE, Brazil

INTRODUCTIONThis study investigated the genetic environment of bla KPC-2 in Klebsiella pnemoniae multi-drug resistant clinical isolates. METHODSFour carbapenemase gene isolates resistant to carbapenems, collected from infected patients from two hospitals in Brazil, were investigated using polymerase...

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Published in:	Revista da Sociedade Brasileira de Medicina Tropical Vol. 53; p. e20190526
Main Authors:	Lima, Giselle Jucá de, Scavuzzi, Alexsandra Maria Lima, Beltrão, Elizabeth Maria Bispo, Firmo, Elza Ferreira, Oliveira, Érica Maria de, Oliveira, Sibele Ribeiro de, Rezende, Antônio Mauro, Lopes, Ana Catarina de Souza
Format:	Journal Article
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical - SBMT 2020 Sociedade Brasileira de Medicina Tropical (SBMT)
Subjects:	bla KPC-2 IncQ1 Klebsiella pnemoniae NTEKPC-IId Short Communication TROPICAL MEDICINE Klebsiella pnemoniae NTEKPC-IId bla KPC-2 IncQ1
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Summary:	INTRODUCTIONThis study investigated the genetic environment of bla KPC-2 in Klebsiella pnemoniae multi-drug resistant clinical isolates. METHODSFour carbapenemase gene isolates resistant to carbapenems, collected from infected patients from two hospitals in Brazil, were investigated using polymerase chain reaction and plasmid DNA sequencing. RESULTSThe bla KPC-2 gene was located between ISKpn6 and a resolvase tnpR in the non-Tn4401 element (NTEKPC-IId). It was detected on a plasmid belonging to the IncQ1 group. CONCLUSIONSTo our knowledge, this is the first report of the presence of the bla KPC-2 gene in the NTEKPC-IId element carried by plasmid IncQ1 from infections in Brazil.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conflict of Interest: The authors declare that there is no conflict of interest. Authors’ Contribution: All authors contributed equally to this manuscript.
ISSN:	0037-8682 1678-9849 1678-9849
DOI:	10.1590/0037-8682-0526-2019