Chondrosarcoma of the Temporomandibular Joint: Systematic Review and Survival Analysis of Cases Reported to Date

The purpose of this systematic review was to summarize the available data on TMJ chondrosarcomas and to perform a survival analysis of cases reported to date. This review was conducted in accordance with the PRISMA . Two authors performed an electronic search of case reports of TMJ chondrosarcoma pu...

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Published in:	Head & neck pathology (Totowa, N.J.) Vol. 15; no. 3; pp. 923 - 934
Main Authors:	Faro, Tatiane Fonseca, Martins-de-Barros, Allan Vinícius, Lima, Gilberto Tenório Wanderley Fernandes, Raposo, André Pereira, Borges, Mariana de Albuquerque, Araújo, Fábio Andrey da Costa, Carvalho, Marianne de Vasconcelos, Nogueira, Emerson Filipe de Carvalho, Laureano Filho, José Rodrigues
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-09-2021
Subjects:	Adolescent Adult Aged Child Chondrosarcoma - mortality Chondrosarcoma - pathology Dentistry Female Humans Male Medicine Medicine & Public Health Middle Aged Oral and Maxillofacial Surgery Original Paper Otorhinolaryngology Pathology Survival Analysis Temporomandibular Joint Disorders - mortality Temporomandibular Joint Disorders - pathology Young Adult Temporomandibular joint Chondrosarcoma Facial neoplasms Temporomandibular joint disorders Head and neck neoplasms Survival Analysis
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Summary:	The purpose of this systematic review was to summarize the available data on TMJ chondrosarcomas and to perform a survival analysis of cases reported to date. This review was conducted in accordance with the PRISMA . Two authors performed an electronic search of case reports of TMJ chondrosarcoma published until August 02, 2020. Forty-seven studies reporting 53 cases were included. Chondrosarcomas of the TMJ were more prevalent in women, with a male:female ratio of 1:1.4. Survival curves were significantly associated with histological diagnosis (p = 0.004), reconstructive surgery (p = 0.024), recurrence (p < 0.001), and distant metastasis (p = 0.001). Only distant metastasis was independently associated with survival (p = 0.017). TMJ chondrosarcomas presented with low recurrence and higher survival rates than other chondrosarcomas. Synovial subtype, absence of reconstructive surgery, and presence of local recurrence or distant metastasis were associated with poorer prognosis .
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	1936-0568 1936-055X 1936-0568
DOI:	10.1007/s12105-021-01313-9