Search Results - "Lima, Dênis Pires"

Carbonyl Compounds′ Journey to Amide Bond Formation by Narendar Reddy, Thatikonda, Beatriz, Adilson, Jayathirtha Rao, Vaidya, de Lima, Dênis Pires

“…The formation of amide bonds is one of the most stimulating emerging areas in organic and medicinal chemistry. Amides are recognized as central building blocks…”
Get full text

Synthesis and biological activity against Trypanosoma cruzi of substituted 1,4-naphthoquinones by Olímpio da Silva, Adriano, da Silva Lopes, Rosangela, Vieira de Lima, Ricardo, Santos Suniga Tozatti, Camila, Marques, Maria Rita, de Albuquerque, Sérgio, Beatriz, Adilson, Pires de Lima, Dênis

“…The discovery and development of essential drugs for Chagas disease is a major concern worldwide. New substituted 1,4-naphthoquinones were synthesized and…”
Get full text

Biological activities of 1,4-naphthoquinones derivatives against T. cruzi and L. amazonensis by Olímpio da Silva, Adriano, Da Silva Lopes, Rosangela, Alves dos Santos Naujorks, Aline, Vataru Nakamura, Celso, Pires de Lima, Dênis

“…Introduction: Chagas disease and Leishmaniasis are neglected diseases caused bythe Trypanosoma cruzi and kentoplastid parasites Leishmania spp. Parasitic…”
Get full text

Recent Advances in the Functionalization of Hydrocarbons: Synthesis of Amides and its Derivatives by Reddy, Thatikonda Narendar, de Lima, Dênis Pires

“…The functionalization of hydrocarbons represents an attractive approach for the synthesis of amides. The amide bond is one of the most fascinating functional…”
Get full text

Insights of Cannabinoid CBD: The Pharmacological Potential and Heterologous Expression by Pinto, Ingrid Batista, Mantovani, Cynthia, de Borba, Danrley Ramires dos Santos, Salina, Gabriela Beatriz, de Lima, Denis Pires, Beatriz, Adilson

“…In this review, a thorough approach was taken to the therapeutic potential of CBD and the possibilities of heterologous expression for its synthesis…”
Get full text

Effects of 3‐Heptyl‐3,4,6‐trimethoxy‐3H‐isobenzofuran‐1‐one alone or/in association with cyclophosphamide on testicular function by Oliveira, Rodrigo Juliano, Cunha‐Laura, Andréa Luiza, Gonçalves, Caroline Amélia, Monreal, Antônio Carlos Duenhas, Costa, Deiler Sampaio, Meza, Alisson, Lima, Dênis Pires, Beatriz, Adilson, Amaral, Ernani Aloysio, Auharek, Sarah Alves

“…Chemotherapy for cancer treatment may result in a temporary or long‐term gonadal damage resulting in subfertility or infertility. Cyclophosphamide (CY) is a…”
Get full text

Thiopyrimidine derivatives induce cytotoxicity, cell cycle arrest and oxidative stress in breast cancer 3D-spheroids by Gomes, Giovana Bicudo, Zubieta, Claudia Stutz, Weber, Simone Schneider, de Lima, Dênis Pires, Reddy, Thatikonda Narendar, Guerrero, Ana Tereza Gomes, de Fatima Cepa Matos, Maria, Parisotto, Eduardo Benedetti, Perdomo, Renata Trentin

“…3D-cultured breast cancer cells had shown relative drug resistance as compared to 2D-cultured cells, and it has been suggested as a new in vitro cell-based…”
Get full text

Diaryl sulfide analogs of combretastatin A-4: Toxicogenetic, immunomodulatory and apoptotic evaluations and prospects for use as a new chemotherapeutic drug by Carvalho, Pamela Castilho, Santos, Edson Anjos, Schneider, Beatriz Ursinos Catelán, Matuo, Renata, Pesarini, João Renato, Cunha-Laura, Andréa Luiza, Monreal, Antônio Carlos Duenhas, Lima, Dênis Pires, Antoniolli, Andréia Conceição Milan Brochado, Oliveira, Rodrigo Juliano

“…Highlights • We tested the biological activity of two new analogs of combretastatin A-4. • Both analogs were found to be genotoxic, mutagenic and also to…”
Get full text

3-Heptylidene-4,6-Dimethoxy-3H-Isobenzofuran-1-One Is Genotoxic, Increases the Frequency of Cell Death, and Potentiates the Effects of Cyclophosphamide and Cisplatin by das Neves, Silvia Cordeiro, de Araújo, Flavio Henrique, Correa, Willian Ayala, Martins, Allana Cristina Faustino, Coelho, Henrique Rodrigues Scherer, Vilela, Marcelo Luiz Brandão, do Nascimento, Valter Aragão, Kassuya, Candida Aparecida Leite, de Lima, Dênis Pires, Beatriz, Adilson, Oliveira, Rodrigo Juliano, Gomes, Roberto da Silva

“…3-heptylidene-4,6-dimethoxy-3H-isobenzofuran-1-one (Phthalide 1) is the precursor of three resorcinol lipids that have been described as potential…”
Get full text

The mixture of cashew nut shell liquid and castor oil results in an efficient larvicide against Aedes aegypti that does not alter embryo-fetal development, reproductive performance or DNA integrity by Vani, Juliana Miron, Monreal, Maria Tereza Ferreira Duenhas, Auharek, Sarah Alves, Cunha-Laura, Andréa Luiza, de Arruda, Eduardo José, Lima, Alessandra Ramos, da Silva, Cicera Maria, Antoniolli-Silva, Andréia Conceição Milan Brochado, de Lima, Dênis Pires, Beatriz, Adilson, Oliveira, Rodrigo Juliano

“…Dengue fever, chikungunya fever and Zika virus are epidemics in Brazil that are transmitted by mosquitoes, such as Aedes aegypti or Aedes albopictus. The…”
Get full text

Antileishmanial Activity, Toxicity and Mechanism of Action of Complexes of Sodium Usnate with Lanthanide Ions: Eu(III), Sm(III), Gd(III), Nd(III), La(III) and Tb(III) by da Silva, Fernanda, Rizk, Yasmin Silva, das Neves, Amarith Rodrigues, Lourenço, Estela Mariana Guimarães, Ferreira, Alda Maria Teixeira, Monteiro, Melquisedeque Mateus, de Lima, Dênis Pires, Perdomo, Renata Trentin, Bonfá, Iluska Senna, Toffoli-Kadri, Mônica Cristina, Duarte, Adriana Pereira, Nunes, Daniel Mendes, Martines, Marco Antonio Utrera, Piranda, Eliane Mattos, de Arruda, Carla Cardozo Pinto

“…Leishmaniases are neglected diseases with limited therapeutic options. Diffuse cutaneous leishmaniasis can occur in Brazil due to . This study details the…”
Get full text

Assessment of acute toxicity and cytotoxicity of fluorescent markers produced by cardanol and glycerol, which are industrial waste, to different biological models by Pelizaro, Bruno Ivo, Braga, Felipe Camargo, Crispim, Bruno do Amaral, de Barros, Luiz Guilherme Maiolino Lacerda, Pessatto, Lucas Roberto, Oliveira, Edwin José Torres, Vani, Juliana Miron, de Souza, Antonio Pancrácio, Grisolia, Alexeia Barufatti, Antoniolli-Silva, Andréia Conceição Milan Brochado, de Lima, Dênis Pires, dos Santos Jaques, Jeandre Augusto, Beatriz, Adilson, Oliveira, Rodrigo Juliano

“…The amphyphylic triazoanilines recently synthesized 1-(4-(3-aminophenyl)-1H-1,2,3- triazole-1-yl)-3-(3-pentadecylphenoxy)propan-2-ol (1) and…”
Get full text

Cardanol: toxicogenetic assessment and its effects when combined with cyclophosphamide by Schneider, Beatriz Ursinos Catelan, Meza, Alisson, Beatriz, Adilson, Pesarini, João Renato, Carvalho, Pamela Castilho de, Mauro, Mariana de Oliveira, Karaziack, Caroline Bilhar, Cunha-Laura, Andréa Luiza, Monreal, Antônio Carlos Duenhas, Matuo, Renata, Lima, Dênis Pires de, Oliveira, Rodrigo Juliano

“…Cardanol is an effective antioxidant and is a compound with antimutagenic and antitumoral activity. Here, we evaluated the genotoxic and mutagenic potential of…”
Get full text

Assessment of the toxicogenic effects and cell death potential of the ester (Z)-methyl 4-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino)-4-oxobut-2-anoate in combination with cisplatin, cyclophosphamide and doxorubicin by Juliano Oliveira, Rodrigo, Pereira, Fabrícia Paniago Ajala Nery, Silveira, Ingridhy Ostaciana Maia Freitas da, Lima, Ricardo Vieira de, Berno, Claudia Rodrigues, Pesarini, João Renato, Antoniolli-Silva, Andréia Conceição Milan Brochado, Monreal, Antônio Carlos Duenhas, Adilson, Beatriz, Lima, Dênis Pires de, Gomes, Roberto da Silva

“…Despite rapid advances in both the early detection and treatment of cancer, the mortality from this disease remains high, which justifies the development of…”
Get full text

Chemical identification of Tagetes minuta Linnaeus (Asteraceae) essential oil and its acaricidal effect on ticks by Garcia, Marcos Valério, Matias, Jaqueline, Barros, Jacqueline Cavalcante, de Lima, Dênis Pires, Lopes, Rosângela da Silva, Andreotti, Renato

“…The control of tick species that affect animal production is vital for the economic welfare of the cattle industry. This study focused on testing the…”
Get full text

In vivo chemotherapeutic insight of a novel isocoumarin (3-hexyl-5,7-dimethoxy-isochromen-1-one): Genotoxicity, cell death induction, leukometry and phagocytic evaluation by Araújo, Flávio Henrique Souza de, Figueiredo, Débora Rojas de, Auharek, Sarah Alves, Pesarini, João Renato, Meza, Alisson, Gomes, Roberto da Silva, Monreal, Antônio Carlos Duenhas, Antoniolli-Silva, Andréia Conceição Milan Brochado, Lima, Dênis Pires de, Kassuya, Candida Aparecida Leite, Beatriz, Adilson, Oliveira, Rodrigo Juliano

“…Chemotherapy is one of the major approaches for the treatment of cancer. Therefore, the development of new chemotherapy drugs is an important aspect of…”
Get full text

Synthesis of angiotensin-converting enzyme (ACE) inhibitors: an important class of antihypertensive drugs by Lima, Dênis Pires de

“…This report outlines the discovery, the design and development of new compounds, and, structure-activity relationships for this drug category. Updated…”
Get full text

A novel cytosporone 3-Heptyl-4,6-dihydroxy-3H-isobenzofuran-1-one: synthesis; toxicological, apoptotic and immunomodulatory properties; and potentiation of mutagenic damage by Oliveira, Rodrigo Juliano, Navarro, Stephanie Dynczuki, de Lima, Dênis Pires, Meza, Alisson, Pesarini, João Renato, da Silva Gomes, Roberto, Karaziack, Caroline Bilhar, de Oliveira Mauro, Mariana, Cunha-Laura, Andréa Luiza, Monreal, Antônio Carlos Duenhas, Romão, Wanderson, Júnior, Valdemar Lacerda, Beatriz, Adilson

“…A large number of studies are attempting to identify alternative products from natural sources or synthesized compounds that effectively interact with cancer…”
Get full text

Impact of Iron Mining Activity on the Endophytic Fungal Community of Aspilia grazielae by Weirich, Carlos Eduardo, Marques, Maria Rita, de Castro, Alinne Pereira, Assumpção Benitez, Beatriz, Roque, Fabio de Oliveira, Marchetti, Clarice Rossato, Rodrigues, Amanda Dal'Ongaro, de Lima, Dênis Pires, Dos Santos, Edson Dos Anjos

“…(J. U. Santos) is an endemic plant species in Morro do Urucum in the Pantanal wetland (Brazil). is used for the restoration of areas impacted by iron mining…”
Get full text

Flavonoid Derivatives as New Potent Inhibitors of Cysteine Proteases: An Important Step toward the Design of New Compounds for the Treatment of Leishmaniasis by Lourenço, Estela Mariana Guimarães, Di Iório, Juliana Fortes, da Silva, Fernanda, Fialho, Felipe Leonardo Bley, Monteiro, Melquisedeque Mateus, Beatriz, Adilson, Perdomo, Renata Trentin, Barbosa, Euzébio Guimarães, Oses, Jean Pierre, de Arruda, Carla Cardozo Pinto, de Souza Júdice, Wagner Alves, Rafique, Jamal, de Lima, Dênis Pires

“…Leishmaniasis is a neglected tropical disease, affecting more than 350 million people globally. However, there is currently no vaccine available against human…”
Get full text