Search Results - "Lima, Andréa C. Paula"

Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease by Paula‐Lima, Andrea C., Brito‐Moreira, Jordano, Ferreira, Sergio T.

“…Alzheimer′s disease (AD) is the most common form of dementia in the elderly. Memory loss in AD is increasingly attributed to soluble oligomers of the amyloid‐β…”
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Periodontal bacteria in the brain—Implication for Alzheimer's disease: A systematic review by Parra‐Torres, Valeria, Melgar‐Rodríguez, Samanta, Muñoz‐Manríquez, Constanza, Sanhueza, Benjamín, Cafferata, Emilio A., Paula‐Lima, Andrea C., Díaz‐Zúñiga, Jaime

“…Periodontitis is a chronic non‐communicable disease caused by a dysbiotic microbiota. Pathogens can spread to the bloodstream, colonize other tissues or…”
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Taurine prevents the neurotoxicity of β‐amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders by Louzada, Paulo Roberto, Lima, Andréa C. Paula, Mendonca‐Silva, Dayde L., Noël, Francois, De Mello, Fernando G., Ferreira, Sérgio T.

“…Alzheimer's disease (AD) and several other neurological disorders have been linked to the overactivation of glutamatergic transmission and exci‐totoxicity as a…”
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Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line by Paula Lima, Andréa C, Arriagada, Christian, Toro, Rodrigo, Cárdenas, Ana María, Caviedes, Raúl, Ferreira, Sergio T, Caviedes, Pablo

“…We have previously characterized a number of small molecule organic compounds that prevent the aggregation of the beta-amyloid peptide and its neurotoxicity in…”
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Contribution of Ca2+ release channels to hippocampal synaptic plasticity and spatial memory: potential redox modulation by Paula-Lima, Andrea C, Adasme, Tatiana, Hidalgo, Cecilia

“…Memory is an essential human cognitive function. Consequently, to unravel the cellular and molecular mechanisms responsible for the synaptic plasticity events…”
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Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer’s Disease by Salech, Felipe, Ponce, Daniela P., Paula-Lima, Andrea C., SanMartin, Carol D., Behrens, María I.

“…Nicotinamide (vitamin B3) is a key component in the cellular production of Nicotinamide Adenine Dinucleotide (NAD) and has long been associated with neuronal…”
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Human apolipoprotein A–I binds amyloid-β and prevents Aβ-induced neurotoxicity by Paula-Lima, Andréa C., Tricerri, M. Alejandra, Brito-Moreira, Jordano, Bomfim, Theresa R., Oliveira, Fabio F., Magdesian, Margaret H., Grinberg, Lea T., Panizzutti, Rogerio, Ferreira, Sérgio T.

“…Aggregates of the amyloid-β peptide (Aβ) play a central role in the pathogenesis of Alzheimer's disease (AD). Identification of proteins that physiologically…”
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Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation by Adasme, Tatiana, Haeger, Paola, Paula-Lima, Andrea C, Espinoza, Italo, Casas-Alarcón, M. Mercedes, Carrasco, M. Angélica, Hidalgo, Cecilia

“…Ryanodine receptors (RyR) amplify activity-dependent calcium influx via calcium-induced calcium release. Calcium signals trigger postsynaptic pathways in…”
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RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid β Peptide Oligomers by SanMartín, Carol D., Veloso, Pablo, Adasme, Tatiana, Lobos, Pedro, Bruna, Barbara, Galaz, Jose, García, Alejandra, Hartel, Steffen, Hidalgo, Cecilia, Paula-Lima, Andrea C.

“…Amyloid β peptide oligomers (AβOs), toxic aggregates with pivotal roles in Alzheimer´s disease, trigger persistent and low magnitude Ca2+ signals in neurons…”
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Amyloid β-peptide oligomers, ryanodine receptor-mediated Ca2+ release, and Wnt-5a/Ca2+ signaling: opposing roles in neuronal mitochondrial dynamics? by Paula-Lima, Andrea C., Hidalgo, Cecilia

“…[...]some evidence implicates activation of these enzymes by AβOs-generated Ca2+ signals. [...]inhibition of the PKC pathway reduces the cell death induced by…”
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Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca2+ uptake in primary hippocampal neurons by SanMartín, Carol D., Paula-Lima, Andrea C., García, Alejandra, Barattini, Pablo, Hartel, Steffen, Núñez, Marco T., Hidalgo, Cecilia

“…Mounting evidence indicates that iron accumulation impairs brain function. We have reported previously that addition of sub-lethal concentrations of iron to…”
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Activation of GABA A receptors by taurine and muscimol blocks the neurotoxicity of β-amyloid in rat hippocampal and cortical neurons by Paula-Lima, Andréa C., De Felice, Fernanda G., Brito-Moreira, Jordano, Ferreira, Sérgio T.

“…The β-amyloid peptide (Aβ) is centrally related to the pathogenesis of Alzheimer's disease (AD) and is potently neurotoxic to central nervous system neurons…”
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Reactive oxygen species released from astrocytes treated with amyloid beta oligomers elicit neuronal calcium signals that decrease phospho-Ser727-STAT3 nuclear content by Muñoz, Yorka, Paula-Lima, Andrea C., Núñez, Marco T.

“…The transcription factor STAT3 has a crucial role in the development and maintenance of the nervous system. In this work, we treated astrocytes with oligomers…”
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Amyloid β-peptide oligomers stimulate RyR-mediated Ca2+ release inducing mitochondrial fragmentation in hippocampal neurons and prevent RyR-mediated dendritic spine remodeling produced by BDNF by Paula-Lima, Andrea C, Adasme, Tatiana, SanMartín, Carol, Sebollela, Adriano, Hetz, Claudio, Carrasco, M Angélica, Ferreira, Sergio T, Hidalgo, Cecilia

“…Soluble amyloid β-peptide oligomers (AβOs), increasingly recognized as causative agents of Alzheimer's disease (AD), disrupt neuronal Ca(2+) homeostasis and…”
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Amyloid-β Oligomers Induce Differential Gene Expression in Adult Human Brain Slices by Sebollela, Adriano, Freitas-Correa, Leo, Oliveira, Fabio F., Paula-Lima, Andrea C., Saraiva, Leonardo M., Martins, Samantha M., Mota, Louise D., Torres, Cesar, Alves-Leon, Soniza, de Souza, Jorge M., Carraro, Dirce M., Brentani, Helena, De Felice, Fernanda G., Ferreira, Sergio T.

“…Cognitive decline in Alzheimer disease (AD) is increasingly attributed to the neuronal impact of soluble oligomers of the amyloid-β peptide (AβOs). Current…”
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Ryanodine receptor-mediated Ca(2+) release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca(2+) uptake in primary hippocampal neurons by Sanmartín, Carol D, Paula-Lima, Andrea C, García, Alejandra, Barattini, Pablo, Hartel, Steffen, Núñez, Marco T, Hidalgo, Cecilia

“…Mounting evidence indicates that iron accumulation impairs brain function. We have reported previously that addition of sub-lethal concentrations of iron to…”
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Activation of GABAA receptors by taurine and muscimol blocks the neurotoxicity of β-amyloid in rat hippocampal and cortical neurons by Paula-Lima, Andréa C., De Felice, Fernanda G., Brito-Moreira, Jordano, Ferreira, Sérgio T.

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Neuroprotection against Aβ and glutamate toxicity by melatonin: Are GABA receptors involved? by Lima, Andréa C. Paula, Louzada, Paulo Roberto, De Mello, Fernando G., Ferreira, Sérgio T.

“…The beta -amyloid peptide (A beta ) is centrally related to the pathogenesis of Alzheimer's disease (AD). Previous studies have suggested that the…”
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Dual role of glutamatergic neurotransmission on amyloid β1-42 aggregation and neurotoxicity in embryonic avian retina by LOUZADA, Paulo Roberto, LIMA, Andréa C, DE MELLO, Fernando G, FERREIRA, Sérgio T

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Amyloid β-peptide oligomers, ryanodine receptor-mediated Ca(2+) release, and Wnt-5a/Ca(2+) signaling: opposing roles in neuronal mitochondrial dynamics? by Paula-Lima, Andrea C, Hidalgo, Cecilia

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